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Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

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Abstract

Theranostic platform, which is equipped with both diagnostic and therapeutic functions, is a promising approach in cancer treatment. From various nanotheranostics studied, iron oxide nanoparticles have advantages since IONPs have good biocompatibility and spatial imaging capability. This review is focused on the IONP-based nanotheranostics for cancer imaging and treatment. The most recent progress for applications of IONP nanotheranostics is summarized, which includes IONP-based diagnosis, magnetic resonance imaging (MRI), multimodal imaging, chemotherapy, hyperthermal therapy, photodynamic therapy, and gene delivery. Future perspectives and challenges are also outlined for the potential development of IONP based theranostics in clinical use.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA

    Xiaoqing Ren, Hongwei Chen, Victor Yang & Duxin Sun

  2. School of Pharmacy, Fudan University, Shanghai, 200433, China

    Xiaoqing Ren

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  1. Xiaoqing Ren
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  2. Hongwei Chen
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Dr. Duxin Sun is a professor in the Department of Pharmaceutical Sciences, University of Michigan. He has joint appointment in the Chemical Biology program, and the Interdisciplinary Medicinal Chemistry program. He serves as the director of Pharmacokinetics (PK) Core and is a member of University of Michigan’s Comprehensive Cancer Center. Also, he has served as chair of the PPB (Physical Pharmacy and Biopharmaceutics) section in AAPS (American Association of Pharmaceutical Scientists); vice president of the American Chinese Pharmaceutical Association (ACPA). Dr. Sun has served on study sections for many grant agencies, such as the NIH, FDA, Cancer Research UK, French National Research Agency, and Italian Ministry of Health.

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Ren, X., Chen, H., Yang, V. et al. Iron oxide nanoparticle-based theranostics for cancer imaging and therapy. Front. Chem. Sci. Eng. 8, 253–264 (2014). https://doi.org/10.1007/s11705-014-1425-y

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