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Prediction of 5-Year Weight Loss and Weight Regain According to Early Weight Loss after Sleeve Gastrectomy

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Abstract

Background

Patients with morbid obesity exhibit sustained weight loss after sleeve gastrectomy (SG), but some individuals exhibit subsequent weight regain in the following years. Early weight loss was proven as a predictor of short- and mid-term weight loss and regain. However, the long-term effects of early weight loss have yet to be fully investigated. This study investigated the predictive effects of early weight loss on long-term weight loss and regain after SG.

Methods

Data of patients who underwent SG from November 2011 to July 2016 and followed through July 2021 were collected retrospectively. Weight regain was defined by weight increase more than 25% of their lost weight at the first postoperative year. Linear regression analysis and Cox proportional hazards analysis were performed to evaluate the correlations among early weight loss, weight loss, and weight regain.

Results

Data of 408 patients were included. The percentages of total weight loss (%TWL) at postoperative months 1, 3, 12, and 60 were 10.6%, 18.1%, 29.3%, and 26.6%, respectively. The %TWL at months 1 and 3 were significantly correlated with %TWL after 5 years (P < .01). The weight regain rate was 29.8% at 5 years. The %TWL at months 1 and 3 significantly influenced weight regain (hazard ratio: 0.87 and 0.89, P = .017 and .008).

Conclusion

Early weight loss may be used to predict weight loss and regain 5 years after SG. Patients with poor early weight loss are recommended to receive early interventions to achieve long-term weight loss and prevent weight regain.

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Data Availability

The data that support the findings of this study are available from the authors upon reasonable request.

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Acknowledgements

This manuscript was edited by Wallace Academic Editing.

Funding

This study did not receive any specific grants from any funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Author notes

  1. Yi-Ting Su and Yen-Hao Su contributed equally to this work.

Authors and Affiliations

  1. Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

    Yi-Ting Su

  2. Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, 291, Zhongzheng Road, Zhonghe District, New Taipei City, 23561, Taiwan

    Yen-Hao Su, Ka-Wai Tam & Shih-Chiang Shen

  3. Metabolic and Weight Management Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan

    Yen-Hao Su, Shih-Yun Wang, Fang-Yi Pai, Chih-Ying Kuo & Shih-Chiang Shen

  4. Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Yen-Hao Su, Ka-Wai Tam, Weu Wang & Shih-Chiang Shen

  5. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Yen-Hao Su & Shih-Chiang Shen

  6. TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan

    Yen-Hao Su & Shih-Chiang Shen

  7. TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan

    Yen-Hao Su & Shih-Chiang Shen

  8. Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan

    Ka-Wai Tam

  9. Clinical Information Department, Quality Management Center, Taichung Veterans General Hospital, Taichung, Taiwan

    Yu-Chun Yen

  10. Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan

    Weu Wang

  11. Xin Tai General Hospital, New Taipei City, Taiwan

    Ming-Te Huang

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  1. Yi-Ting Su
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Corresponding author

Correspondence to Shih-Chiang Shen.

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Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed Consent

Informed Consent does not apply.

Conflict of Interest

The authors include Yi-Ting Su, Yen-Hao Su, Ka-Wai Tam, Yu-Chun Yen, Weu Wang, Ming-Te Huang, Shih-Yun Wang, Fang-Yi Pai, Chih-Ying Kuo, and Shih-Chiang Shen and have no conflicts of interest or financial ties to disclose.

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Key points

• Early weight loss predicts 5-year weight loss and regain after sleeve gastrectomy.

• Early weight loss is defined as weight loss at post-operative months 1 and 3.

• Early interventions are needed for patients with poor early weight loss.

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Su, YT., Su, YH., Tam, KW. et al. Prediction of 5-Year Weight Loss and Weight Regain According to Early Weight Loss after Sleeve Gastrectomy. OBES SURG 33, 1366–1372 (2023). https://doi.org/10.1007/s11695-023-06527-0

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  • DOI: https://doi.org/10.1007/s11695-023-06527-0

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