Abstract
Purpose
Obesity is very prevalent among children and adolescents these days. Obese children are at increased risk of vitamin D and other micronutrient deficiencies. This risk is even higher in children and adolescents with morbid obesity who are candidates for bariatric surgery. Although multiple studies have studied the prevalence of vitamin D deficiency in adults undergoing bariatric surgery, studies are limited concerning adolescents in this regard. We aimed to study the prevalence of vitamin D deficiency and insufficiency and calcium status among morbidly obese children and adolescents.
Materials and Methods
A number of 96 adolescents (20 years old and younger) with morbid obesity (BMI ≥ 99% percentile), who were candidates for bariatric surgery, were enrolled in this study (from 2016 to 2018), and their serum vitamin D and calcium levels were measured.
Results
Sixty-four percent of the patients were vitamin D-deficient and 15.7% of them had insufficient levels of serum vitamin D. Only 20.2% of the children had sufficient serum vitamin D levels. Serum calcium levels were within the normal range among all of the patients. There was no significant relationship between age and sex with vitamin D levels.
Conclusion
Vitamin D deficiency is of very high prevalence among adolescents with morbid obesity.
Graphical abstract
Similar content being viewed by others
References
Lespessailles E, Toumi H. Vitamin D alteration associated with obesity and bariatric surgery. Exp Biol Med (Maywood). 2017;242(10):1086–94.
González-Gross M, Valtueña J, Breidenassel C, et al. Vitamin D status among adolescents in Europe: the Healthy Lifestyle in Europe by Nutrition in Adolescence study.
Khosravi-Boroujeni H, Sarrafzadegan N, Sadeghi M, et al. Prevalence and trends of vitamin D deficiency among Iranian adults: a longitudinal study from 2001–2013. J Nutr Sci Vitaminol (Tokyo). 2017;63(5):284–90.
Mihrshahi S, Gow ML, Baur LA. Contemporary approaches to the prevention and management of paediatric obesity: an Australian focus. Med J Aust. 2018;209(6):267–74.
Olson ML, Maalouf NM, Oden JD. Vitamin D deficiency in obese children and its relationship to glucose homeostasis. J Clin Endocrinol Metab. 2012;97(1):279–85.
Szlagatys-Sidorkiewicz A, Brzezinski M, Jankowska A. Long-term effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme (a double-blind placebo-controlled study) - rationale for the study design. BMC Pediatr. 2017;17(1):97.
Stein EM, Strain G, Sinha N, et al. Vitamin D insufficiency prior to bariatric surgery: risk factors and a pilot treatment study. Clin Endocrinol (Oxf). 2009;71(2):176–83.
Bacci V, Silecchia G. Vitamin D status and supplementation in morbid obesity before and after bariatric surgery. Expert Rev Gastroenterol Hepatol. 2010;4(6):781–94.
Pannu PK, Zhao Y, Soares MJ. Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutr Res. 2016;36(3):201–13.
Xanthakos SA. Nutritional deficiencies in obesity and after bariatric surgery. Pediatr Clin North Am. 2009;56(5):1105–21.
Rafraf M, Hasanabad SK, Jafarabadi MA. Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan. Iran Public Health Nutr. 2014;17(4):803–9.
Roth CL, Elfers C, Kratz M, et al. Vitamin d deficiency in obese children and its relationship to insulin resistance and adipokines. J Obes. 2011;2011:495101.
Mansouri M, Abasi R, Nasiri M, et al. Association of vitamin D status with metabolic syndrome and its components: a cross-sectional study in a population of high educated Iranian adults. Diabetes Metab Syndr. 2018;12(3):393–8.
Mantziari S, Duvoisin C, Demartines N, et al. [Long-term results (>/= 10 years) after bariatric surgery: review of the literature]. Rev Med Suisse. 2018;14(599):636–40.
Hanafy AS, Elkatawy HA. Beneficial effects of vitamin D on insulin sensitivity, blood pressure, abdominal subcutaneous fat thickness, and weight loss in refractory obesity. Clin Diabetes. 2018;36(3):217–25.
Chernoguz A, Chwals WJ. Bariatric surgery needs a seat at the children’s table: bridging the perception and reality of the role of bariatric surgery in the treatment of obesity in adolescents. Clin Ther. 2018;40(10):1648–54.
Schilling PL, Davis MM, Albanese CT, et al. National trends in adolescent bariatric surgical procedures and implications for surgical centers of excellence. J Am Coll Surg. 2008;206(1):1–12.
da Rosa CL, Dames Olivieri Saubermann AP, Jacqueline J, et al. Routine supplementation does not warrant the nutritional status of vitamin d adequate after gastric bypass Roux-en-Y. Nutr Hosp. 2013;28(1):169–72.
Obispo Entrenas A, Legupin Tubio D, Lucena Navarro F, et al. Relationship between vitamin D deficiency and the components of metabolic syndrome in patients with morbid obesity, before and 1 year after laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy. Obes Surg. 2017;27(5):1222–8.
Vivan MA, Kops NL, Fülber ER, et al. Prevalence of vitamin D depletion, and associated factors, among patients undergoing bariatric surgery in Southern Brazil. Obes Surg. 2019;29(10):3179–87.
Himbert C, Ose J, Delphan M, et al. A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status. Nutr Res. 2017;38:13–26.
Elhag W, El Ansari W, Abdulrazzaq S, et al. Evolution of 29 anthropometric, nutritional, and cardiometabolic parameters among morbidly obese adolescents 2 years post sleeve gastrectomy. Obes Surg. 2018;28(2):474–82.
Luger M, Kruschitz R, Kienbacher C, et al. Vitamin D3 loading is superior to conventional supplementation after weight loss surgery in vitamin D-deficient morbidly obese patients: a double-blind randomized placebo-controlled trial. Obes Surg. 2017;27(5):1196–207.
Bandstein M, Schultes B, Ernst B, et al. The role of FTO and vitamin D for the weight loss effect of Roux-en-Y gastric bypass surgery in obese patients. Obes Surg. 2015;25(11):2071–7.
Schaaf C, Gugenheim J. Impact of preoperative serum vitamin D level on postoperative complications and excess weight loss after gastric bypass. Obes Surg. 2017;27(8):1982–5.
Censani M, Stein EM, Shane E, et al. Vitamin D deficiency is prevalent in morbidly obese adolescents prior to bariatric surgery. ISRN Obes. 2013;2013:284516.
Sayadi Shahraki M, Khalili N, Yousefvand S, et al. Severe obesity and vitamin D deficiency treatment options before bariatric surgery: a randomized clinical trial. Surg Obes Relat Dis. 2019;15(9):1604–11.
Pereira-Santos M, Costa PR, Assis AM, et al. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16(4):341–9.
Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131(1):e152–61.
Gutiérrez-Medina S, Gavela-Pérez T, Domínguez-Garrido MN, et al. High prevalence of vitamin D deficiency among spanish obese children and adolescents. An Pediatr (Barc). 2014;80(4):229–35.
Lopez EH, Munie S, Higgins R, et al. Morbidity and mortality after bariatric surgery in adolescents versus adults. J Surg Res. 2020;256:180–6.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethics Approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Consent to Participate
Informed consent was obtained from all individual participants included in the study.
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Key Points
• Vitamin D deficiency is very common in adolescents with severe obesity.
• Calcium level is normal even in low levels of serum vitamin D.
• There is no significant relationship between vitamin D level and sex.
Rights and permissions
About this article
Cite this article
Soheilipour, F., Hamidabad, N.M. Vitamin D and Calcium Status Among Adolescents with Morbid Obesity Undergoing Bariatric Surgery. OBES SURG 32, 738–741 (2022). https://doi.org/10.1007/s11695-021-05809-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-021-05809-9