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Impact of Weight Loss with Laparoscopic Sleeve Gastrectomy on Left Ventricular Diastolic Function: a Prospective Study

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Abstract

Purpose

The present study purposed to investigate the effects of weight loss with LSG on echocardiographic parameters of diastolic dysfunction in subjects with morbid obesity.

Methods

Sixty-one subjects undergoing LSG for standard indications were enrolled. All subjects underwent a physical examination, electrocardiography, and transthoracic echocardiography before and 6 months after the LSG. Peak early diastolic velocity (E), deceleration time (DT), and peak late diastolic velocity (A) were measured from the transmitral flow signal. Peak early (e′) diastolic mitral annular velocity was measured at the two acquisition sites (basal septal and basal lateral) using the tissue Doppler recordings.

Results

A significant improvement was observed in echocardiographic measures of the diastolic function including E/A ratio, E/e′ ratio, DT, and isovolumic relaxation time (IVRT) from baseline to the postoperative 6 months. Left atrial volume index (LAVI) reduced from 30.3 ± 3.9 ml/m2 to 28.0 ± 3.3 ml/m2 (p < 0.001). In addition, interventricular septum diameter (IVSD) significantly decreased from 11.3 ± 1.3 mm to 10.2 ± 1.1 mm (p < 0.001). The change in BMI was significantly correlated with the improvements in DT (r = 0.334, p = 0.012), E/e′ (r = 0.440, p = 0.001), E/A (r = − 0.317, p = 0.017), and IVRT (r = 0.348, p = 0.008).

Conclusion

LSG leads to a significant improvement in echocardiographic measures of the left ventricular diastolic function in subjects with obesity. Our findings also show that LSG leads to a reverse remodeling indicated by the decrease in interventricular septum thickness and left atrial volume index in this population.

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Authors and Affiliations

  1. Mehmet Akif İnan Eğitim Ve Araştırma Hastanesi Kardiyoloji Kliniği Esentepe Mah, Ertuğrul Cad. 132 A, 63040, Şanlıurfa Merkez/Haliliye/Şanlıurfa, Turkey

    Bedri Caner Kaya

  2. Şanlıurfa Eğitim Ve Arastırma Hastanesi Genel Cerrahi Klinigi, Şanlıurfa, Turkey

    Hasan Elkan

Authors
  1. Bedri Caner Kaya
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  2. Hasan Elkan
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Correspondence to Bedri Caner Kaya.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

Patient Selection

The present prospective cohort study was conducted on patients with morbid obesity who were scheduled for LSG in Sanliurfa Mehmet Akif Inan Research and Training Hospital between December 2018 and June 2019.

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Kaya, B.C., Elkan, H. Impact of Weight Loss with Laparoscopic Sleeve Gastrectomy on Left Ventricular Diastolic Function: a Prospective Study. OBES SURG 30, 3280–3286 (2020). https://doi.org/10.1007/s11695-020-04573-6

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  • DOI: https://doi.org/10.1007/s11695-020-04573-6

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