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Gender Influence on Long-Term Weight Loss and Comorbidities After Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: a Prospective Study With a 5-Year Follow-up

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Abstract

Background

Gender might be important in predicting outcomes after bariatric surgery. The aim of the study was to investigate the influence of gender on long-term weight loss and comorbidity improvement after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).

Methods

A cohort of 304 consecutive patients underwent surgery in 2006–2009: 162 (98 women, 64 men) underwent LSG and 142 (112 women, 30 men) underwent LRYGB. The mean follow-up time was 75.8 ± 8.4 months (range, 60–96 months).

Results

Overall mean (95 % CI) reduction in BMI was 23.5 (24.3–22.7) kg/m2 after 5 years, with no statistical difference between LSG and LRYGB groups (P = 0.94). The overall means ± standard deviations of %EBMIL after 5 years were 78.8 ± 23.5 and 81.6 ± 21.4 in the LSG and LRYGB groups, respectively. Only for LSG group %EBMIL after 24–36 and 60 months differed significantly between male and female patients (P = 0.003 versus P = 0.06 in LRYGB), and 89 versus 90 % of patients showed improvements in comorbidities in the LSG and LRYGB groups, respectively. Only two patients (women) were lost to follow-up: 1/162 (0.6 %) for LSG at the 4th year and 1/142 (0.7 %) for LRYGB to the 5th year.

Conclusions

LSG was more effective in obese male than in female patients in terms of %EBMIL, with no difference in comorbidities. LRYGB elicited similar results in both genders in terms of %EBMIL and comorbidities.

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Conflict of Interest

The authors declare that they have no competing interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

informed consent was obtained from all individual participants included in the study.

Author information

Authors and Affiliations

  1. General Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy

    Federico Perrone, Domenico Benavoli, Valeria Tognoni, Achille L. Gaspari & Paolo Gentileschi

  2. Bariatric Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy

    Paolo Gentileschi

  3. Psychiatric Unit, Department of System Medicine, University of Rome, Tor Vergata, Italy

    Emanuela Bianciardi, Cinzia Niolu & Alberto Siracusano

Authors
  1. Federico Perrone
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  2. Emanuela Bianciardi
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  3. Domenico Benavoli
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  4. Valeria Tognoni
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  5. Cinzia Niolu
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  6. Alberto Siracusano
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  7. Achille L. Gaspari
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  8. Paolo Gentileschi
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Correspondence to Federico Perrone.

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Perrone, F., Bianciardi, E., Benavoli, D. et al. Gender Influence on Long-Term Weight Loss and Comorbidities After Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: a Prospective Study With a 5-Year Follow-up. OBES SURG 26, 276–281 (2016). https://doi.org/10.1007/s11695-015-1746-z

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  • DOI: https://doi.org/10.1007/s11695-015-1746-z

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