Abstract
Background
Chronic pain (CP) is a prevalent and disabling diagnosis in obese individuals, but how bariatric surgery patients respond to chronic pain rehabilitation treatment programs has not previously been described.
Objectives
The aim of this study was to compare treatment outcomes of a chronic pain rehabilitation program (psychological and pain variables, medication use, treatment completion rates) for post-bariatric surgery patients to those of a non-bariatric surgery control group.
Setting
Three week outpatient multidisciplinary chronic pain program in an academic medical center.
Methods
This was a retrospective case-control study. Medical records of patients admitted to the Pain Rehabilitation Center at Mayo Clinic from 2008 to 2012 were reviewed. One hundred six patients with a history of bariatric surgery (cases) were identified and matched to 106 patients without a history of bariatric surgery (controls) on age, gender, and smoking status (n = 202). Matched t tests and McNemar’s tests were used for analyses.
Results
Mean age was 46 years; 91 % were female and 58 % were non-smokers. The majority of cases (71 %) had undergone Roux-en-Y gastric bypass. Bariatric patients had higher rates of benzodiazepine use at discharge (33 vs. 19 %, p = 0.0433) and were less likely to complete treatment (87 vs. 97 %, p = 0.007) compared to controls. Morphine equivalent use for cases was 127.3 mg ± 135.4 (n = 62) compared to 88.3 mg ± 95.3 (n = 62), p = 0.12, for controls at admission.
Conclusions
These results suggest that bariatric patients may be at risk for treatment non-adherence and have difficulty reducing medication use in the treatment of chronic pain.
Similar content being viewed by others
References
Ogden CL, Carroll MD, Kit BK, et al. Prevalence of obesity in the United States, 2009–2010. NCHS data brief, no 82. Hyattsville: National Center for Health Statistics; 2012.
Townsend CO, Kerkvliet JL, Bruce BK, et al. A longitudinal study of the efficacy of a comprehensive pain rehabilitation program with opioid withdrawal: comparison of treatment outcomes based on opioid use status at admission. Pain. 2008;140:177–89.
Institute of Medicine report from the Committee on advancing pain research, care, and education: relieving pain in America, a blueprint for transforming prevention, care, education and research. The National Academies Press, 2011.
Melo IT, São-Pedro M. Musculoskeletal pain in lower limbs in obese patients before and after bariatric surgery. Arq Bras Cir Dig. 2012;25(1):29–32.
Stone AA, Broderick JE. Obesity and pain are associated in the United States. Obesity. 2012;20(7):1491–5. Epub 2012 Jan 19.
Peltonen M, Lindroos AK, Torgerson JS. Musculoskeletal pain in the obese: a comparison with a general population and long-term changes after conventional and surgical obesity treatment. Pain. 2003;104(3):549–57.
Hitt HC, McMillen RC, Thornton-Neaves T, et al. Comorbidity of obesity and pain in a general population: results from the Southern Pain Prevalence Study. J Pain. 2007;8(5):430–6. Epub 2007 Mar 6.
Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;14:1724–37.
Buchwald H, Oienm DM. Metabolic/bariatric surgery worldwide. Obes Surg. 2011;23:427–36.
De Zwaan M, Lancaster KL, Mitchell JE, et al. Health-related quality of life in morbidly obese patients: effect of gastric bypass surgery. Obes Surg. 2002;12(6):773–80.
Chou R, Clark E, Helfand M. Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: a systematic review. J Pain Symptom Manag. 2003;26:1026–48.
Kalso E, Edwards JE, Moore RA, et al. Opioids in chronic non-cancer pan: a systemic review of efficacy and safety. Pain. 2004;112:372–80.
Bailey AM, Wermeling DP. Naloxone for opioid overdose prevention: pharmacists’ role in community-based practice. Ann Pharmacother. 2014.
Raebel MA, Newcomer SR, Reifler LM, et al. Chronic use of opioid medications before and after bariatric surgery. JAMA. 2013;310(13):1369–76.
Hooten WM, Vickers KS, Shi Y, et al. Smoking cessation and chronic pain: patient and pain medicine physician attitudes. Pain Pract. 2011;11(6):552–63.
Hooten VM, Knight-Brown M, Townsend CO, et al. Clinical outcomes of multidisciplinary pain rehabilitation among African Americans compared with Caucasian patients with chronic pain. Pain Med. 2012;13:1499–508.
Townsend CO, Bruce BK, Hooten WM, et al. The role of mental health professionals in multidisciplinary pain rehabilitation programs. J Clin Psychol. 2006;62:1433–43.
Cunningham JL, Rome JD, Kerkvliet JL, et al. Reduction in medication costs for patients with chronic nonmalignant pain completing a pain rehabilitation program: a prospective analysis of admission, discharge, and 6-month follow-up medication costs. Pain Med. 2009;10:787–96.
DuPen S, DuPen A. Opioid conversion calculator [computer program]. Cynergy Group: Poulsbo, WA; 2000.
Bernstein IH, Jaremko ME, Hinkley BS. On the utility of the West Haven-Yale multidimensional pain inventory. Spine. 1995;20:956–63.
McHorney CA, Ware Jr JE, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993;31:247–63.
Ware Jr JE, Sherbourne CD. The MOS 36-item short form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–83.
Radloff L. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401.
Sullivan M, Pivik J. The pain catastrophizing scale: development and validation. Psychol Assess. 1995;7:524–32.
Holzberg AD, Robinson ME, Geisser ME. The effects of depression and chronic pain on psychosocial and physical functioning. Clin J Pain. 1996;12:118–25.
Dysvik E, Lindstrøm TC, Eikeland OJ, et al. Health-related quality of life and pain beliefs among people suffering from chronic pain. Pain Manag Nurs. 2004;5(2):66–74.
Sullivan MD, Edlund MJ, Fan MY, et al. Risks for possible and probable opioid misuse among recipients of chronic opioid therapy in commercial and medicaid insurance plans. Pain. 2010;150(2):332–9.
Boudreau D, Von Korff M, Rutter CM, et al. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf. 2009;18(12):1166–75.
Cunningham JL, Hayes SE, Townsend CO, et al. Associations between spousal or significant other solicitous responses and opioid dose in patients with chronic pain. Pain Med. 2012;13(8):1034–9.
Dunn KM, Saunders KW, Rutter CM, et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med. 2010;152:85–92.
Bohnert AS, Valenstein M, Bair MJ, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011;305:1315–21.
Lötsch J, Weiss M, Ahne G, et al. Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers. Anesthesiology. 1999;90(4):1026–38.
Tan T, Kuramoto M, Takahashi T, et al. Characteristics of the gastro-intestinal absorption of morphine in rats. Chem Pharm Bull (Tokyo). 1989;37(1):168–73.
Lloret Linares C et al. Pharmacology of morphine in obese patients: clinical implications. Clin Pharmacokinet. 2009;48:635–51.
Svensson PA, Anveden A, Romeo S, et al. Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study. Obesity (Silver Spring). 2013;21(12):2444–5.
Steffen KJ, Engel SG, Pollert GA, et al. Blood alcohol concentrations rise rapidly and dramatically after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2013;9(3)):470–3.
King WC, Chen JY, Mitchell JE, et al. Prevalence of alcohol use disorders before and after bariatric surgery. JAMA. 2012;307(23):2516–25.
Conflict of interest
All contributing authors, Anilga Tabibian, Karen B. Grothe, Manpreet S. Mundi, Todd A. Kellogg, Matthew M. Clark, and Cynthia O. Townsend, declare that they have no conflict of interest.
A Statement of Informed Consent
Informed consent was obtained from all individual participants included in the study.
A Statement of Human and Animal Rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Disclosures
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tabibian, A., Grothe, K.B., Mundi, M.S. et al. Bariatric Surgery Patients’ Response to a Chronic Pain Rehabilitation Program. OBES SURG 25, 1917–1922 (2015). https://doi.org/10.1007/s11695-015-1634-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-015-1634-6