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Great Health Benefits But No Change in Employment or Psychopharmaceutical Drug Use 2 Years After Roux-en-Y Gastric Bypass

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Abstract

Background

The aim was to examine health benefits and lifestyle factors after Roux-en-Y gastric bypass (RYGB).

Methods

Patients (n = 165) were investigated 2 years after RYGB in relation to psychopharmaceutical drugs, employment status, type 2 diabetes mellitus (T2DM), hypertension, metabolic syndrome (MetS), body weight, physical activity (PA), and energy intake.

Results

Excess weight loss (EWL) was 71.4 ± 20.6 %. Prevalence of T2DM, hypertension, and MetS was reduced (P < 0.001 for all). There were no changes in the use of psychopharmaceutical drugs (20.6 vs. 18.8 %, P = 0.549) or in the proportion of unemployed participants (37.7 vs. 33.3 %, P = 0.189) from pre- to post-surgery. Eighty-three percent achieved EWL ≥50 %. These subjects had a lower pre-surgery BMI. We found no differences in the prevalence of hypertension, T2DM, and MetS pre-surgery, but the prevalence was lower after surgery compared with subjects with EWL <50 %.

Conclusion

RYGB induced remission of T2DM, hypertension, and MetS 2 years after surgery. The benefit was greatest in the group with EWL ≥50 %. Despite excellent weight loss, there was no change in the use of psychopharmaceutical drugs or proportion of unemployed participants.

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Abbreviations

BW:

Body weight

EI:

Energy intake

EE:

Energy expenditure

EWL:

Excess weight loss

HbA1c :

Glycosylated hemoglobin A1c

MET:

Metabolic equivalents

MetS:

Metabolic syndrome

PA:

Physical activity

RYGB:

Roux-en-Y gastric bypass

T2DM:

Type 2 diabetes mellitus

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Acknowledgments

We appreciate Ingunn Bergstad’s (chief dietitian) contribution in facilitating the project and for input to the manuscript, master students in clinical nutrition for data collection, Diabetes Laboratory and Central Laboratory for blood samples and blood analysis, and the staff at the Department of Nutrition, University of Oslo, for their help with analyses of dietary data. The study is financially supported by the Norwegian Extra Foundation for Health and Rehabilitation through EXTRA funds, grant number 2011/2/0264.

Conflict of Interest

The corresponding author (Susanna E Hanvold) has received research grants from the Norwegian Extra Foundation for Health and Rehabilitation through EXTRA funds (grant number 2011/2/0264). The other authors (Elin B Løken, Sofie F Paus, Eva Rustad de Brisis, Kirsti Bjerkan, Helga Refsum, Anne-Marie Aas) declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Author information

Authors and Affiliations

  1. Division of Medicine, Department of Clinical Service, Section of Nutrition and Dietetics, Oslo University Hospital Aker, Oslo, Norway

    Susanna E. Hanvold, Kirsti Bjerkan & Anne-Marie Aas

  2. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway

    Susanna E. Hanvold, Elin B. Løken & Helga Refsum

  3. Vestfold Hospital Trust, Tønsberg, Norway

    Sofie F. Paus

  4. Vestre Viken Hospital Trust, Bærum, Norway

    Eva Rustad de Brisis

  5. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Section of Endocrinology, Oslo University Hospital Aker, Oslo, Norway

    Kirsti Bjerkan

  6. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

    Anne-Marie Aas

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  1. Susanna E. Hanvold
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Corresponding author

Correspondence to Susanna E. Hanvold.

Additional information

Helga Refsum and Anne-Marie Aas shared last authorship.

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Hanvold, S.E., Løken, E.B., Paus, S.F. et al. Great Health Benefits But No Change in Employment or Psychopharmaceutical Drug Use 2 Years After Roux-en-Y Gastric Bypass. OBES SURG 25, 1672–1679 (2015). https://doi.org/10.1007/s11695-015-1583-0

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