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The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass

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Abstract

Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6 %, p = nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4 %, p = 0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.

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Fig. 1
Fig. 2

Abbreviations

PRA:

Percent relative abundance

PPI:

Proton pump inhibitor

RYGB:

Roux-en-Y gastric bypass

LRYGB:

Laparoscopic Roux-en-Y gastric bypass

PWL:

Percent weight loss

PEWL:

Percent excess weight loss

NS:

Nonsignificant

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Acknowledgments

This project was supported by a grant from the Colorado Clinical Translational Science Institute Project Grant (5UL1RR025780).

Conflict of Interest

No conflicts of interest exist for any of the authors.

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No writing assistance was provided for this manuscript.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, University of Colorado Denver, Academic Office Building 1, 12631 East 17th Avenue, Room 7614, MS B158, Aurora, CO, 80045, USA

    Emily K. Ward & Gregory L. Austin

  2. Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Dara P. Schuster, Katie H. Stowers & Amanda K. Royse

  3. Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Dara P. Schuster

  4. Division of Infectious Diseases and Microbiome Research Consortium (MiRC), University of Colorado Denver, Aurora, CO, USA

    Diana Ir & Daniel N. Frank

  5. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA

    Charles E. Robertson

Authors
  1. Emily K. Ward
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  2. Dara P. Schuster
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  3. Katie H. Stowers
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  4. Amanda K. Royse
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  5. Diana Ir
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  6. Charles E. Robertson
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  7. Daniel N. Frank
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  8. Gregory L. Austin
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Corresponding author

Correspondence to Gregory L. Austin.

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Ward, E.K., Schuster, D.P., Stowers, K.H. et al. The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass. OBES SURG 24, 1567–1571 (2014). https://doi.org/10.1007/s11695-014-1275-1

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  • DOI: https://doi.org/10.1007/s11695-014-1275-1

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