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Gastric Bypass Increases Ethanol and Water Consumption in Diet-Induced Obese Rats

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An Erratum to this article was published on 15 December 2012

Abstract

Background

Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for morbid obesity. Increased alcohol abuse after RYGB resulted in recommendations to exclude patients with alcohol abuse histories from RYGB. The purpose of our study was to examine the effects of a RYGB on ethanol intake in diet-induced obese rats (high-fat diet).

Methods

The animals underwent RYGB and were habituated along with their sham-operated obese controls and with lean rats to increasing concentrations of ethanol in a two-bottle choice paradigm.

Results

RYGB rats' daily consumption of ethanol averaged 2 g/kg at 2 % habituation and 3.8 g/kg at 4 % habituation, twice as much as sham-operated obese controls and 50 % more than normal-diet lean controls. Obese controls drank on average 1 g/kg of ethanol (2 and 4 %), significantly less (50 %) than lean controls did. RYGB rats when given higher ethanol concentrations (6 and 8 %) or no ethanol drank significantly more water than lean and obese controls did (66 and 100 %, respectively), and their enhanced total fluid intake was associated with increased food intake, which was significantly higher than in lean (66 % more calories; food + alcohol) and obese controls (44 % more calories). The lower alcohol intake in the obese controls than in the lean rats suggests that obesity may interfere with alcohol's rewarding effects and RYGB may remove this protective effect.

Conclusions

The overall enhancement of consummatory behaviors (both ethanol and water) suggests that RYGB may facilitate alcohol consumption, which in vulnerable individuals could lead to abuse and addiction.

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Acknowledgments

This work was supported by the NIAAA (AA 11034 & AA07574, AA07611) DK080899 (AH).

We thank the SULI program for partial support of Mike Subrize. We also thank Nikhil K. Acharya, Robert Bellezza, and Michael Miller for their help with the care of the animals.

Conflict of Interest

Panayotis K. Thanos, Ph.D., Mike Subrize, B.S., Foteini Delis, Ph.D., Robert N. Cooney, M.D., Derek Culnan, M.D., Mingjie Sun, Ph.D., Gene-Jack Wang, M.D., Nora D. Volkow, M.D., and Andras Hajnal, M.D., Ph.D., do not have any conflict of interest to disclose.

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Author notes

  1. Robert N. Cooney

    Present address: Department of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA

Authors and Affiliations

  1. Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA

    Panayotis K. Thanos & Nora D. Volkow

  2. Behavioral Neuropharmacology and Neuroimaging Lab, Brookhaven National Laboratory, Upton, NY, USA

    Panayotis K. Thanos, Mike Subrize, Foteini Delis & Gene-Jack Wang

  3. Department of Neural and Behavioral Sciences, Pennsylvania State University, University Park, PA, USA

    Mingjie Sun & Andras Hajnal

  4. Department of Surgery, Pennsylvania State University, University Park, PA, USA

    Robert N. Cooney, Derek Culnan, Mingjie Sun & Andras Hajnal

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  1. Panayotis K. Thanos
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  2. Mike Subrize
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Correspondence to Panayotis K. Thanos.

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Thanos, P.K., Subrize, M., Delis, F. et al. Gastric Bypass Increases Ethanol and Water Consumption in Diet-Induced Obese Rats. OBES SURG 22, 1884–1892 (2012). https://doi.org/10.1007/s11695-012-0749-2

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  • DOI: https://doi.org/10.1007/s11695-012-0749-2

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