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Assessment of Selenium in Roux-en-Y Gastric Bypass and Gastric Banding Surgery

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Abstract

Background

Until recently, there was limited documented data on both dietary and serum selenium deficiency in bariatric surgery. We performed an evaluation of selenium intake and both serum selenium and glutathione peroxidase (GTP; as a functional measurement of selenium) before and after roux-en-Y (RNY) gastric bypass and gastric banding surgery.

Methods

The endpoints obtained from the subjects included dietary intake of selenium and vitamins E and C, as well as serum levels of selenium, GTP and vitamins E. These were analyzed at pre-surgery (baseline) and 3 and 12 months post surgery.

Results

Dietary deficiencies in selenium intake (38.2 % recommended daily allowance) were noted at 3 months, but not baseline or 12 months, in the gastric bypass group. No dietary deficiencies were noted in the lap band group. For both surgeries, there was a significant reduction from baseline to 3 months in both serum selenium and GTP levels (p = 0.033 and 0.0033 respectively). The serum selenium levels and GTP levels both trended back toward baseline values by 12 months without concomitant selenium supplementation. Mean GTP levels were below normal at all three time points while mean serum selenium levels were all at or above normal.

Conclusions

This study shows that RNY gastric bypass and laparoscopic adjustable gastric banding procedures, and accompanying dietary restrictions, increases the risk for disturbances of selenium and GTP homeostasis. Consideration for selenium supplementation at higher levels than the current RDA of 55 mcg daily during the first 3 months and perhaps longer should be studied further.

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Authors and Affiliations

  1. Department of Endocrinology, Diabetes and Metabolism and Clinical Research Division of the Bassett Research Institute, Bassett Medical Center, 1 Atwell Road, Cooperstown, NY, 13326, USA

    Amy Freeth

  2. Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, 4301 W. Markham Street, slot 587, Little Rock, AR, 72205, USA

    Petpring Prajuabpansri

  3. Clinical Research Division of the Bassett Research Institute, Bassett Medical Center, 1 Atwell Road, Cooperstown, NY, 13326, USA

    Jennifer M. Victory

  4. Department of Statistics and Epidemiology Research of the Bassett Research Institute, Bassett Medical Center, 1 Atwell Road, Cooperstown, NY, 13326, USA

    Paul Jenkins

Authors
  1. Amy Freeth
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  2. Petpring Prajuabpansri
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  3. Jennifer M. Victory
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  4. Paul Jenkins
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Corresponding author

Correspondence to Amy Freeth.

Additional information

The source of financial and material support comes from E. Donnall Thomas Resident Research Grant, Bassett Research Institute, 1 Atwell Road Cooperstown, NY 13326.

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Freeth, A., Prajuabpansri, P., Victory, J.M. et al. Assessment of Selenium in Roux-en-Y Gastric Bypass and Gastric Banding Surgery. OBES SURG 22, 1660–1665 (2012). https://doi.org/10.1007/s11695-012-0680-6

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  • DOI: https://doi.org/10.1007/s11695-012-0680-6

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