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Evolution of Lipid Profiles after Bariatric Surgery

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An Erratum to this article was published on 21 December 2011

Abstract

Background

The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points.

Methods

One hundred twenty eight (N = 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients (N = 114), 84 of whom were women (73.7%), were finally included in the study.

Results

Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP (P < 0.0005 for all). Inversely, HDL cholesterol disclosed a significant rise (P < 0.0005). Noteworthy significant associations between lipid subfractions and EWL were detected overall (P < 0.0005 for all). A gender effect was found since female patients displayed a milder association than male patients (P < 0.0005).

Conclusions

LRYGBP-induced weight loss improves the lipid profile while reducing insulin resistance, with male patients showing a better profile than female patients.

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Conflicts of Interest

None to be disclosed.

Author information

Authors and Affiliations

  1. Centro Laparoscópico Dr. Ballesta (CLB), Centro Médico Teknon, 08022, Barcelona, Spain

    Ignacio Garcia-Marirrodriga, Cesar Amaya-Romero, Gabriel Patiño Ruiz-Diaz & Carlos Ballesta-López

  2. Resistencia a la Insulina SL, 08035, Barcelona, Spain

    Sandra Férnandez

  3. Servicio de Endocrinología y Nutrición, Clinica CIMA, 08034, Barcelona, Spain

    Juan Ybarra

  4. Baldwin-Wallace College, Berea, OH, USA

    June H. Romeo

  5. Endocrinology Department, Hospital de la Santa Creu i de Sant Pau, Barcelona, Spain

    Juan Ybarra

  6. Servicio de Endocrinología y Nutrición, Hospital de Sant Pau, 08025, Barcelona, Spain

    Jose Ma. Pou

  7. Cardiovascular Research Center (CSIC-ICCC), Institut Català de Ciències Cardiovasculars (ICCC) Hospital Sta. Creu i St. Pau, Av. Sant Antoni Maria Claret, 167, 08025, Barcelona, Spain

    Gemma Vilhur

  8. Cardiovascular Research Center (CSIC-ICCC), Institut Català de Ciències Cardiovasculars Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni M. Claret 167, 08025, Barcelona, Spain

    Lina Badimon

Authors
  1. Ignacio Garcia-Marirrodriga
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  2. Cesar Amaya-Romero
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  3. Gabriel Patiño Ruiz-Diaz
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  5. Carlos Ballesta-López
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  6. Jose Ma. Pou
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  9. Lina Badimon
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  10. Juan Ybarra
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Corresponding author

Correspondence to Juan Ybarra.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s11695-011-0584-x.

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Garcia-Marirrodriga, I., Amaya-Romero, C., Ruiz-Diaz, G.P. et al. Evolution of Lipid Profiles after Bariatric Surgery. OBES SURG 22, 609–616 (2012). https://doi.org/10.1007/s11695-011-0534-7

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