Abstract
Obesity-associated microvascular dysfunction (MVD) involves different body tissues, including skin, and concurs to increased cardiovascular risk in obese patients (Ob-P). Generalized improvement of MVD is an important goal in obesity treatment. Since skin MVD mirrors generalized systemic MVD, skin microvascular investigation in prospective studies in Ob-P may surrogate microvascular investigation in organs more important for cardiovascular risk of the studied patients. In this prospective study, we measured forearm skin post-occlusive reactive hyperaemia (PORH), as percentage flow increase from baseline, and skin vasomotion in 37 Ob-P before Roux-en-Y gastric bypass (RYGB), and in 24 of them about 1 year after RYGB, using laser Doppler flowmetry (LDF). The spectral contribution of skin LDF signal oscillations in the frequency intervals of 0.01–0.02 Hz, 0.02–0.06 Hz, and 0.06–0.2 Hz—corresponding to endothelial-, sympathetic-, and myogenic-dependent vasomotion, respectively, was measured by means of spectral Fourier analysis. The same measurements were also performed in 28 healthy, lean subjects (HLS). Before RYGB, Ob-P had a significant reduction in PORH and in the all vasomotion parameters investigated, compared with HLS. After RYGB, Ob-P who completed the follow-up, had a significant weight loss (∼40 kg on average), together with a full normalisation in PORH and in vasomotion parameters, regardless of diabetes status. Surgically induced sustained weight loss resulted in full normalisation of skin microvascolar function in Ob-P about 1 year after RYGB. This result suggests a beneficial effect of sustained weight loss on generalized MVD of the studied Ob-P.
Similar content being viewed by others
References
Hubert HB, Feinleib M, McNamara PM, et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67:968–77.
Wilding J. Science, medicine, and the future. Obesity treatment. BMJ. 1997;315:997–1000.
de Jongh RT, Serne EH. RGIJ et al. Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation. 2004;109:2529–35.
Jonk AM, Houben AJ, de Jongh RT, et al. Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Physiology. 2007;22:252–60.
Stapleton PA, James ME, Goodwill GA, et al. Obesity and vascular dysfunction. Pathophysiology. 2008;2:79–89.
de Jongh RT, Serné EH, IJzerman RG, et al. Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women. Microvasc Res. 2008;75:256–62.
Steinberg HO, Chaker H, Leaming R, et al. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601–10.
Pierce GL, Beske SD, Lawson BR, et al. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension. 2008;52:72–9.
Dengel DR, Kelly AS, Olson TP, et al. Effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults. Metabolism. 2006;55:907–11.
Karason K, Wikstrand J, Sjöström L, et al. Weight loss and progression of early atherosclerosis in the carotid artery: a four-year controlled study of obese subjects. Int J Obes Relat Metab Disord. 1999;23:948–56.
Lind L, Zethelius B, Sundbom M, et al. Vasoreactivity is rapidly improved in obese subjects after gastric bypass surgery. Int J Obes. 2009;33:1390–5.
Holowatz LA, Thompson-Torgerson CS, Kenney WL. The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol. 2008;105:370–2.
Rossi M, Ricco R, Carpi A. Spectral analysis of skin laser Doppler blood perfusion signal during skin hyperemia in response to acetylcholine iontophoresis and ischemia in normal subjects. Clin Hemorheol Microcirc. 2004;31:303–10.
Stewart J, Kohen A, Brouder D, et al. Non-invasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure. Am J Physiol Heart Circ Physiol. 2004;287:H2687–96.
Rossi M, Carpi A, Di Maria C, et al. Absent post-ischemic increase of blood flowmotion in the skin microcirculation of healthy chronic cigarette smokers. Clin Hemorheol Microcirc. 2007;36:163–71.
Shamim-Uzzaman QA, Pfenninger D, Kehrer C, et al. Altered cutaneous microvascular responses to reactive hyperaemia in coronary artery disease: a comparative study with conduit vessel responses. Clin Sci (Lond). 2002;103:267–73.
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diab Care. 2002;25:S5–20.
Stefanovska A, Bracic M, Kvernmo K. Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng. 1999;46:1230–9.
Kvernmo HD, Stefanovska A, Kirkeboen KA, et al. Oscillations in the human skin blood perfusion signal modified by endothelium-dependent and endothelium-independent vasodilators. Microvasc Res. 1999;57:298–309.
Benbow SJ, Pryce DW, Noblett K, et al. Flow motion in peripheral diabetic neuropathy. Clin Sci (Lond). 1995;88:191–6.
Schmiedel O, Schroeter ML, Harvey JN. Microalbuminuria in Type 2 diabetes indicates impaired microvascular vasomotion and perfusion. Am J Physiol Heart Circ Physiol. 2007;293:H3424–4231.
Binggeli C, Spieker LE, Corti R, et al. Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice? J Am Coll Cardiol. 2003;42:71–7.
Joyner MJ, Dietz NM, Shepherd JT. From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. J Appl Physiol. 2001;91:2431–41.
Vuilleumier P, Decosterd D, Maillard M, et al. Postischemic forearm skin reactive hyperemia is related to cardiovascular risk factors in a healthy female population. J Hypertens. 2002;20:1753–7.
Nilsson H, Aalkjaer C. Vasomotion: mechanisms and physiological importance. Mol Interv. 2003;3:79–89.
Ursino M, Cavalcanti S, Bertuglia S, et al. Theoretical analysis of complex oscillations in multibranched microvascular networks. Microvasc Res. 1996;23:229–49.
Parthimos D, Edwards DH, Griffith TM. Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow. Cardiovasc Res. 1996;31:388–99.
Sakurai T, Terui N. Effects of sympathetically induced vasomotion on tissue-capillary fluid exchange. Am J Physiol Heart Circ Physiol. 2006;291:H1761–7.
Soderstrom T, Stefanovska A, Veber M, et al. Involvement of sympathetic nerve activity in skin blood flow oscillation in humans. Am J Physiol Heart Circ Physiol. 2003;284:H1638–46.
Stauss HM, Anderson EA, Haynes WG, et al. Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol. 1998;274:H1277–83.
Lamboley M, Schuster A, Bény JL, et al. Recruitment of smooth muscle cells and arterial vasomotion. Am J Physiol Heart Circ Physiol. 2003;285:H562–9.
Stansberry KB, Shapiro SA, Hill MA, et al. Impaired peripheral vasomotion in diabetes. Diab Care. 1996;19:715–21.
Kellogg DL. In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges. J Appl Physiol. 2006;100:1709–18.
Acknowledgements
We thank the Hospital of Pisa for support in the part of this study concerning the laser Doppler flowmetry investigation.
Conflicts of interest
The authors declare no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rossi, M., Nannipieri, M., Anselmino, M. et al. Skin Vasodilator Function and Vasomotion in Patients with Morbid Obesity: Effects of Gastric Bypass Surgery. OBES SURG 21, 87–94 (2011). https://doi.org/10.1007/s11695-010-0286-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-010-0286-9