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Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up

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Abstract

Background: Metabolic syndrome is a group of pathological processes which involve insulin resistance, a biochemical and molecular disorder. Obesity appears to be the most frequent clinical component in metabolic syndrome. Subcutaneous fat, independent from visceral fat, is still controversial as a marker of the pathophysiology of insulin resistance.

Methods: An open parallel-group clinical trial was performed of 12 women (age 30–40 years), with BMI from 30–33 kg/m2 and fasting glucose ≤110 mg/dl. 6 women were included in the “liposuction plus diet” group, and 6 were included in the “diet-only” group. Metabolic profile, including insulin tolerance test (ITT), leptin and tumor necrosis factor alpha (TNFα), was performed at baseline, 1 and 6 months in both groups. Subcutaneous and visceral fat was quantified with spiral tomography at baseline and after 6 months. Friedman and Wilcoxon test were used for intra-group differences, Mann-Whitney U for differences between groups, and Spearman test for correlation, with significance set atP<0.05.

Results: No difference existed between groups regarding clinical characteristics and metabolic profile. In the liposuction group, the increase in insulin sensitivity was (3.8±0.86, 3.1±0.85, 4.5±1.02 %/min,P=0.08. Insulin sensitivity did not correlate with subcutaneous fat, leptin, or TNFα. Leptin diminished at 1 month (52.7±6.04 vs 31.6±11.9),P=0.028, and correlated with the subcutaneous fat (r=0.957). In the diet-only group, TNFα diminished at 6 months,P=0.046.

Conclusion: Subcutaneous abdominal fat correlates with leptin; nevertheless, it is a weak marker for TNFα and insulin sensitivity.

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Authors and Affiliations

  1. Medical Research Unit in Clinical Epidemiology, Medical Unit of High Speciality, Mexican Institute of Social Security, Guadalajara, Mexico

    José Antonio Robles-Cervantes MD, MSc, PhD, Esperanza Martínez-Abundis MD, MSc, PhD, Manuel González-Ortiz MD, MSc, PhD & Eduardo Hernández-Salazar MD, MSc

  2. Reconstructive Surgery Institute, Health Ministry, Guadalajara, Mexico

    José Antonio Robles-Cervantes MD, MSc, PhD & Lázaro Cárdenas-Camarena MD

  3. Radio Imagen de Occidente, Guadalajara, Mexico

    Rafael Olvera-Ozuna MD

Authors
  1. José Antonio Robles-Cervantes MD, MSc, PhD
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  2. Esperanza Martínez-Abundis MD, MSc, PhD
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  3. Manuel González-Ortiz MD, MSc, PhD
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  4. Lázaro Cárdenas-Camarena MD
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  5. Eduardo Hernández-Salazar MD, MSc
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  6. Rafael Olvera-Ozuna MD
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Correspondence to José Antonio Robles-Cervantes MD, MSc, PhD.

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Robles-Cervantes, J.A., Martínez-Abundis, E., González-Ortiz, M. et al. Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up. OBES SURG 17, 1242–1247 (2007). https://doi.org/10.1007/s11695-007-9213-0

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  • DOI: https://doi.org/10.1007/s11695-007-9213-0

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