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Relationship among Adiponectin, Adiponectin Gene Expression and Fatty Acids Composition in Morbidly Obese Patients

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Background

he aim of this study was to examine the relationship between adiponectin plasma circulating levels and its gene expression in two abdominal fat depots (subcutaneous and visceral) with the fatty acid composition of plasma and adipose tissue in morbidly obese subjects.

Methods

20 patients (10 women and 10 men) were selected. All were morbidly obese (BMI ≥40 kg/m2) and admitted for gastric surgery. Plasma samples and adipose tissue from both subcutaneous and visceral regions were obtained. Plasma adiponectin and adipose adiponectin expression were analyzed.

Results

Adiponectin mRNA expression in the subcutaneous tissue was significantly higher (P––.048) than in visceral tissue. Circulating adiponectin values, were positively associated with the proportion of n-3 polyunsaturated fatty acids in plasma (r––.62, P––.002). The visceral depot showed greater statistical associations between adiponectin gene expression and fatty acids profile, being saturated fatty acids associated with a decrease (r– −0.68, P––.015), whereas monounsaturated were related to an increase in this adipose region (r––.67, P––.017).

Conclusions

e demonstrated significant associations between adipose tissue adiponectin gene expression and fatty acid composition. These associations were more evident in relation to the visceral depot, an adipose tissue region highly implicated in the metabolic syndrome.

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Abbreviations

AT:

adipose tissue

n-3 :

n-3 polyunsaturated fatty acids

n-6 :

n-6 polyunsaturated fatty acids

MUFA:

monounsaturated fatty acids

SFA:

saturated fatty acids

PUFA:

polyunsaturated fatty acid

WC:

waist circumference

PCR:

polymerase chain reaction

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Authors and Affiliations

  1. Department of Physiology, University of Murcia, Murcia, Spain

    Juan Jose Hernandez-Morante PhD, Elvira Larque PhD, Salvador Zamora PhD & Marta Garaulet PhD

  2. Department of Physiology and Nutrition, University of Navarra, Navarra, Spain

    Fermin Ignacio Milagro PhD & Jose Alfredo Martinez PhD

  3. General Surgery Service, University Hospital “Virgen de la Arrixaca”, Murcia, Spain

    Juan Lujan MD

  4. Department of Physiology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain

    Marta Garaulet PhD

Authors
  1. Juan Jose Hernandez-Morante PhD
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  2. Fermin Ignacio Milagro PhD
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  3. Elvira Larque PhD
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  4. Juan Lujan MD
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  5. Jose Alfredo Martinez PhD
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  6. Salvador Zamora PhD
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  7. Marta Garaulet PhD
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Corresponding author

Correspondence to Marta Garaulet PhD.

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Hernandez-Morante, J.J., Milagro, F.I., Larque, E. et al. Relationship among Adiponectin, Adiponectin Gene Expression and Fatty Acids Composition in Morbidly Obese Patients. OBES SURG 17, 516–524 (2007). https://doi.org/10.1007/s11695-007-9090-6

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  • DOI: https://doi.org/10.1007/s11695-007-9090-6

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