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Factors influencing peak bone mass gain

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Abstract

Bone mass is a key determinant of osteoporosis and fragility fractures. Epidemiologic studies have shown that a 10% increase in peak bone mass (PBM) at the population level reduces the risk of fracture later in life by 50%. Low PBM is possibly due to the bone loss caused by various conditions or processes that occur during adolescence and young adulthood. Race, gender, and family history (genetics) are responsible for the majority of PBM, but other factors, such as physical activity, calcium and vitamin D intake, weight, smoking and alcohol consumption, socioeconomic status, age at menarche, and other secondary causes (diseases and medications), play important roles in PBM gain during childhood and adolescence. Hence, the optimization of lifestyle factors that affect PBM and bone strength is an important strategy to maximize PBM among adolescents and young people, and thus to reduce the low bone mass or osteoporosis risk in later life. This review aims to summarize the available evidence for the common but important factors that influence bone mass gain during growth and development and discuss the advances of developing high PBM.

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Acknowledgements

This study was supported by the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China (No. LR17H070001) and the National Natural Science Foundation of China (No. 81871831). The funding agencies had no role in the study design, data collection and analysis, and decision to publish or preparation of the manuscript. We thank the peer reviewers for their thorough and helpful review of this manuscript.

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  1. Disease & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, 310024, China

    Xiaowei Zhu & Houfeng Zheng

  2. Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, 310024, China

    Xiaowei Zhu & Houfeng Zheng

  3. School of Life Sciences, Fudan University, Shanghai, 200433, China

    Xiaowei Zhu & Houfeng Zheng

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Xiaowei Zhu and Houfeng Zheng declare that they have no conflicts of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Zhu, X., Zheng, H. Factors influencing peak bone mass gain. Front. Med. 15, 53–69 (2021). https://doi.org/10.1007/s11684-020-0748-y

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