Abstract
Nowadays, pyogenic liver abscess (PLA) is still a common and severe intra-abdominal infection, and Klebsiella pneumoniae had emerged as the most common pathogenic bacteria worldwide in the past ten years. Our study aims to achieve an early pathogenic diagnosis and rational therapy modality for Klebsiella pneumoniae liver abscess (KLA) through clinical data analysis. A total of 197 inpatients in Zhongshan Hospital, Shanghai, diagnosed as having liver abscess between March 2001 and September 2009 were enrolled. Patients with monomicrobial infection were divided into two groups: patients with K. pneumoniae liver abscess (KLA group, n = 106) and those with non-Klebsiella pneumoniae liver abscess (NKLA group, n = 56). A retrospective analysis was made between these two groups on the aspects of underlying diseases, clinical characteristics, laboratory data, culture results, and imaging findings. To evaluate the effects of different medical interventions, monomicrobial KLA patients were further divided into four subgroups (percutaneous liver aspiration, aspiration plus antibiotics flushing, aspiration plus retained catheter, and aspiration plus antibiotics flushing and retained catheter), and corresponding therapeutic effects were analyzed. KLA was more likely to occur in patients with coexisting diseases such as diabetes mellitus (53.77% vs 25.00%, P = 0.001) and hepatic adipose infiltration (16.04% vs 5.36%, P = 0.029). Compared to NKLA group, clinical characteristics including abdominal pain (40.57% vs 57.14%, P = 0.044), hypodynamia (19.81% vs 46.43%, P = 0.001), and hepatomegaly (4.72% vs 14.29%, P = 0.033) were much milder, but with a higher fasting blood glucose level (7.84 ± 0.36 vs 5.76 ± 0.30, P = 0.001) on admission in KLA group. In addition, KLA abscess often appeared singly in the right lobe of the liver with gas forming nature (32.88% vs 13.51%, P = 0.039), unsmooth rim (71.23% vs 40.54%, P = 0.002), and dynamic septum enhancement (41.10% vs 16.22%, P = 0.009). Compared to mono aspiration subgroup, additional antibiotic flushing could not further improve clinical outcomes of KLA patients (P > 0.05); however, the retained catheter showed obvious advantage in reducing abscess diameter (34.38 ± 3.25 mm vs 22.67 ± 2.37 mm, P = 0.017). It can be concluded that the strong association with diabetes, milder clinical symptoms, and gas-forming nature in CT images makes early pathogenic diagnosis of KLA possible. Comparatively, ultrasonography-guided percutaneous liver aspiration with retained catheter may be the most rational intervention modality of KLA.
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References
Cheung N K, Malfitan R C, Najem A Z, Rush B F Jr. Pyogenic liver abscess. Am Surg, 1978, 44(5): 272–278
Rahimian J, Wilson T, Oram V, Holzman R S. Pyogenic liver abscess: recent trends in etiology and mortality. Clin Infect Dis, 2004, 39(11): 1654–1659
Lee K T, Wong S R, Sheen P C. Pyogenic liver abscess: an audit of 10 years’ experience and analysis of risk factors. Dig Surg, 2001, 18(6): 459–465, discussion 465–466
Kim S B, Je B K, Lee K Y, Lee S H, Chung H H, Cha S H. Computed tomographic differences of pyogenic liver abscesses caused by Klebsiella pneumoniae and non-Klebsiella pneumoniae. J Comput Assist Tomogr, 2007, 31(1): 59–65
Lederman E R, Crum N F. Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics. Am J Gastroenterol, 2005, 100(2): 322–331
Hui J Y, Yang M K, Cho D H, Li A, Loke T K, Chan J C, Woo P C. Pyogenic liver abscesses caused by Klebsiella pneumoniae: US appearance and aspiration findings. Radiology, 2007, 242(3): 769–776
Pastagia M, Arumugam V. Klebsiella pneumoniae liver abscesses in a public hospital in Queens, New York. Travel Med Infect Dis, 2008, 6(4): 228–233
Pope J V, Teich D L, Clardy P, McGillicuddy D C. Klebsiella pneumoniae liver abscess: an emerging problem in North America. J Emerg Med, 2008, Nov 6. [epub ahead of print] doi:10.1016/j. jemermed.2008.04.041
Lee H L, Lee H C, Guo H R, Ko W C, Chen K W. Clinical significance and mechanism of gas formation of pyogenic liver abscess due to Klebsiella pneumoniae. J Clin Microbiol, 2004, 42(6): 2783–2785
Medeiros A A. Nosocomial outbreaks of multiresistant bacteria: extended-spectrum beta-lactamases have arrived in North America. Ann Intern Med, 1993, 119(5): 428–430
Chan K S, Yu W L, Tsai C L, Cheng K C, Hou C C, Lee M C, Tan C K. Pyogenic liver abscess caused by Klebsiella pneumoniae: analysis of the clinical characteristics and outcomes of 84 patients. Chin Med J (Engl), 2007, 120(2): 136–139
Fallon R J. The relationship between the biotype of Klebsiella species and their pathogenicity. J Clin Pathol, 1973, 26(7): 523–528
Kang C I, Kim S H, Bang J W, Kim H B, Kim N J, Kim E C, Oh M D, Choe K W. Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance. J Korean Med Sci, 2006, 21(5): 816–822
Schiappa D A, Hayden M K, Matushek M G, Hashemi F N, Sullivan J, Smith K Y, Miyashiro D, Quinn J P, Weinstein R A, Trenholme G M. Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: a case-control and molecular epidemiologic investigation. J Infect Dis, 1996, 174(3): 529–536
Wiener J, Quinn J P, Bradford P A, Goering R V, Nathan C, Bush K, Weinstein R A. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. JAMA, 1999, 281(6): 517–523
Wong W M, Wong B C, Hui C K, Ng M, Lai K C, Tso W K, Lam S K, Lai C L. Pyogenic liver abscess: retrospective analysis of 80 cases over a 10-year period. J Gastroenterol Hepatol, 2002, 17(9): 1001–1007
Elgindy N, Lindholm H, Gunvén P. High-dose percutaneous ethanol injection therapy of liver tumors. Patient acceptance and complications. Acta Radiol, 2000, 41(5): 458–463
Okano H, Shiraki K, Inoue H, Kawakita T, Yamamoto N, Deguchi M, Sugimoto K, Sakai T, Ohmori S, Murata K, Nakano T. Clinicopathological analysis of liver abscess in Japan. Int J Mol Med, 2002, 10(5): 627–630
Yang C C, Yen C H, Ho M W, Wang J H. Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae. J Microbiol Immunol Infect, 2004, 37(3): 176–184
Lim S W, Lee E J, Lee S W, Kim S M, Kim J H, Kim B J, Jang B I, Kim T N, Chung M K. Clinical significance of Klebsiella pneumoniae in liver abscess. Korean J Gastroenterol, 2003, 42(3): 226–231
Moon W K, Im J G, Yeon K M, Han M C. Complications of Klebsiella pneumonia: CT evaluation. J Comput Assist Tomogr, 1995, 19(2): 176–181
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Li, J., Fu, Y., Wang, JY. et al. Early diagnosis and therapeutic choice of Klebsiella pneumoniae liver abscess. Front. Med. China 4, 308–316 (2010). https://doi.org/10.1007/s11684-010-0103-9
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DOI: https://doi.org/10.1007/s11684-010-0103-9