Skip to main content
SpringerLink
Log in

The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis of infantile persistent jaundice

  • Research Article
  • Published:
Frontiers of Medicine in China Aims and scope Submit manuscript

Abstract

The aim of this study was to investigate the value of technetium etifenin injection (99mTc-EHIDA) hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia. 99mTc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile jaundice. For diagnosing biliary atresia, the sensitivity and specificity of scintigraphy were 100% and 74.5%, respectively; the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%, respectively. In conclusion, hepatobiliary scintigraphy, which is a noninvasive, safe, valuable examination method, in combination with examination of duodenal fluid, is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Huang Z H, Dong Y C. Dynamic duodenal fluid examination for differential diagnosis of infantile continuous obstructive jaundice. Zhonghua Er Ke Za Zhi, 2004, 42(1): 54–56 (in Chinese)

    PubMed  Google Scholar 

  2. Lee C H, Wang P W, Lee T T, Tiao M M, Huang F C, Chuang J H, Shieh C S, Cheng Y F. The significance of functioning gallbladder visualization on hepatobiliary scintigraphy in infants with persistent jaundice. J Nucl Med, 2000, 41(7): 1209–1213

    CAS  PubMed  Google Scholar 

  3. Gerhold J P, Klingensmith W C 3rd, Kuni C C, Lilly J R, Silverman A, Fritzberg A R, Nixt T L. Diagnosis of biliary atresia with radionuclide hepatobiliary imaging. Radiology, 1983, 146(2): 499–504

    CAS  PubMed  Google Scholar 

  4. Nadel H R. Hepatobiliary scintigraphy in children. Semin Nucl Med, 1996, 26(1): 25–42

    Article  CAS  PubMed  Google Scholar 

  5. Charearnrad P, Chongsrisawat V, Tepmongkol S, Poovorawan Y. The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. J Med Assoc Thai, 2003, 86(Suppl 2): S189–S194

    PubMed  Google Scholar 

  6. Esmaili J, Izadyar S, Karegar I, Gholamrezanezhad A. Biliary atresia in infants with prolonged cholestatic jaundice: diagnostic accuracy of hepatobiliary scintigraphy. Abdom Imaging, 2007, 32(2): 243–247

    Article  PubMed  Google Scholar 

  7. Poddar U, Bhattacharya A, Thapa B R, Mittal B R, Singh K. Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med, 2004, 45(9): 1488–1492

    CAS  PubMed  Google Scholar 

  8. Fischler B, Woxenius S, Nemeth A, Papadogiannakis N. Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection. J Pediatr Surg, 2005, 40(3): 541–546

    Article  PubMed  Google Scholar 

  9. Fjaer R B, Bruu A L, Nordbø S A. Extrahepatic bile duct atresia and viral involvement. Pediatr Transplant, 2005, 9(1): 68–73

    Article  PubMed  Google Scholar 

  10. Stipsanelli K, Koutsikos J, Papantoniou V, Arka A, Palestidis C, Tsiouris S, Manolaki A, Zerva C. Hepatobiliary scintigraphy and gamma-GT levels in the differential diagnosis of extrahepatic biliary atresia. Q J Nucl Med Mol Imaging, 2007, 51(1): 74–81

    CAS  PubMed  Google Scholar 

  11. Greene H L, Helinek G L, Moran R, O’Neill J. A diagnostic approach to prolonged obstructive jaundice by 24-hour collection of duodenal fluid. J Pediatr, 1979, 95(3): 412–414

    Article  CAS  PubMed  Google Scholar 

  12. Faweya A G, Akinyinka O O, Sodeinde O. Duodenal intubation and aspiration test: utility in the differential diagnosis of infantile cholestasis. J Pediatr Gastroenterol Nutr, 1991, 13(3): 290–292

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Sheng-Xuan Liu & Zhi-Hua Huang

Authors
  1. Sheng-Xuan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhi-Hua Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhi-Hua Huang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, SX., Huang, ZH. The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis of infantile persistent jaundice. Front. Med. China 4, 342–345 (2010). https://doi.org/10.1007/s11684-010-0099-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11684-010-0099-1

Keywords

Search

Navigation