Abstract
To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood pressure, lipid profiles and blood glucose level. By using PCR-RFLP, the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure. Taking into account eNOS Glu298Asp polymorphisms, the relationship of blood pressure with triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose level was analyzed. The distribution of eNOS Glu298Asp polymorphism had no significant difference between different blood pressure groups and gender groups, but there was a significant difference between different age groups, diastolic blood pressure groups or BMI groups (P < 0.05). Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L (P = 0.03, OR = 2.65). eNOS Glu298Asp polymorphism and serum lipid could synergistically modulate the blood pressure. eNOS Asp/Asp genotype could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L. eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.
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Pereira A C, Sposito A C, Mota G F, Cunha R S, Herkenhoff F L, Mill J G, Krieger J E. Endothelial nitric oxide synthase gene variant modulates the relationship between serum cholesterol levels and blood pressure in the general population: New evidence for a direct effect of lipids in arterial blood pressure. Atherosclerosis, 2006, 184(1): 193–200
Heltianu C, Costache G, Gafencu A, Diaconu M, Bodeanu M, Cristea C, Azibi K, Poenaru L, Simionescu M. Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction. J Cell Mol Med, 2005, 9(1): 135–142
Wolff B, Grabe H J, Schlüter C, Popowski K, Völzke H, Lüdemann J, John U, Felix S B, Cascorbi I. Endothelial nitric oxide synthase Glu298Asp gene polymorphism, blood pressure and hypertension in a general population sample. J Hypertens, 2005, 23(7): 1361–1366
Yoon S, Shin C, Park H Y, Moon J, Kim E, Kim H T, Min J, Jo S A, Jo I. Endothelial nitric oxide synthase gene is associated with vessel. Clin Chim Acta, 2005, 353(1–2): 177–185
Kishimoto T, Misawa Y, Kaetu A, Nagai M, Osaki Y, Okamoto M, Yoshida S, Kurosawa Y, Fukumoto S. eNOS Glu298Asp polymorphism and hypertension in a cohort study in Japanese. Prev Med, 2004, 39(5): 927–931
Zhu H, Wang X, Dong Y, Treiber F A, Snieder H. Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youth. Pharmacogent Genomics, 2005, 15(9): 669–675
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Translated from Journal of Third Military Medical University, 2007, 29(5): 448–450 [译自: 第三军医大学学报]
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Tang, Z., Li, J. & Yang, J. Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile and blood glucose level. Front. Med. China 2, 178–181 (2008). https://doi.org/10.1007/s11684-008-0033-y
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DOI: https://doi.org/10.1007/s11684-008-0033-y