Abstract
The aim of this research was to investigate the effects of modafinil, a new wake-promoting agent, on vestibular function during 24 h sleep deprivation (SD) so as to provide experimental evidence for the rational use of this drug among air crew. Eight young, healthy male volunteers were exposed to two 24 h periods of continuous wakefulness during the crossover experiment. Initially, 200 mg dose of modafinil was given, and one week later, a matching placebo was administered. The SD time started from 08:00 of the first day to 08:00 of the second day. Drugs were given at 0:00 on the second day. Vestibular function was tested at 21:00 on the first day and 1, 3, 5, 7 h after drug administration. The accuracy of saccade tracking and gains in visual-vestibular optokinetic reflex (VVOR) and optokinetic nystagmus (OKN) in the placebo group decreased during 24 h SD, especially at 01:00-05:00 on the second day, while OKN gains in the modafinil group increased significantly. There were no significant differences in the other vestibular functional indices between the modafinil group and placebo group. The 24 h SD can influence vestibular function to a certain degree, but modafinil may improve OKN.
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References
Zhan H, Guan H. Application of psychotropic drugs for sleep regulation and anti-fatigue in aircrew during war-time. Chin J Aerospace Med, 1997, 8(1): 48–51
Li Y F, Zhan H, Xin Y M, Tang G X, Wei S H, Wang L, Jing Y G. Effects of modafinil on cognitive ability of health young men during 48 h sleep deprivation. Chin J Aerospace Med, 2002, 13(4): 230–234
Li Y F, Zhan H, Xin Y M, Tang G X, Wei S H, Li T. Effects of modafinil on visual and auditory ability and subjective fatigue level during 48 h sleep deprivation. Space Medicine & Medical Engineering, 2003, 16(4): 277–280
Yu L S. Measuring Techniques for Vestibular Function. Beijing: People’s Military Surgeon Press, 1994, 22–97
Uimonen S, Laitakari K, Bloigu R. The repeatability of posturographic measurements and the effects of sleep deprivation. J Vestib Res, 1994, 4(1): 29–36
Collins W E. Some effects of sleep loss on vestibular responses. Aviat Space Environ Med, 1988, 59(6): 523–529
Effects of sleep deprivation on vestibule-ocular reflex. AD—666750
Wong Y N, King S P, Simcoe D. Open-label, single-dose pharmacokinetic study of modafinil tablets: Influence of age and gender in normal subjects. J Clin Pharmacol, 1999, 39(3): 281–288
Wong Y N, Simcoe D, Hartman L N. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. J Clin Pharmacol, 1999, 39(1): 30–40
Robertson P Jr, Hellriegel E T. Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet, 2003, 42(2): 123–137
Dowd P, Moore E W, Cramer R L. Relationships of fatigue and motion sickness to vestibulo-ocular responses to coriolis stimulation. Human Factors, 1975, 17(1): 95–105
The Effects of Sleep Deprivation on Spatial Disorientation. USAARL Report No. 2000-09
Zhan H, Jing B S, Li Y F, Guo H, Li T, Wei S H, Tang G X. Effects of modafinil on simulated flight performance during 48h sleep deprivation. Space Medicine & Medical Engineering, 2006, 19(2):102–105
Zhan H, Geng X C, Xie S J, Yan G D, Jia H B, Wei S H, Jing B S. Effects of modafinil on human basic +Gz tolerance and Coriolis acceleration tolerance. Chin J Aerospace Med, 2005, 16(2):95–97
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Translated from Space Medicine & Medical Engineering, 2006, 19(1): 16–18 [译自: 航天医学与医学工程]
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Zhan, H., Xie, S., Jia, H. et al. Effects of modafinil on vestibular function during 24 hour sleep deprivation. Front. Med. China 1, 226–229 (2007). https://doi.org/10.1007/s11684-007-0044-0
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DOI: https://doi.org/10.1007/s11684-007-0044-0