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Coupling of cerebral blood flow and functional connectivity is decreased in healthy aging

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Abstract

Aging leads to cerebral perfusion and functional connectivity changes that have been assessed using various neuroimaging techniques. In addition, a link between these two parameters has been demonstrated in healthy young adults. In this work, we employed arterial spin labeling (ASL) fMRI to measure global and voxel-wise differences in cerebral blood flow (CBF) and intrinsic connectivity contrast (ICC) in the resting state in a group of cognitively normal elderly subjects and a group of cognitively normal young subjects, in order to assess the effects of aging on CBF-ICC coupling, which had not been previously evaluated. Our results showed age-related global and regional CBF decreases in prefrontal mesial areas, lateral frontal regions, insular cortex, lateral parietal areas, precuneus and occipital regions. Subcortically, perfusion was reduced in the medial thalamus and caudate nucleus. ICC was also found reduced with age in prefrontal cortical areas and insular cortex, affecting key nodes of the default mode and salience networks. Areas of ICC and CBF decrease partially overlapped, however, the CBF reduction was more extensive and encompassed more areas. This dissociation was accompanied by a decrease in CBF-ICC coupling. These results suggest that aging leads to a disruption in the relationship between CBF and intrinsic functional connectivity that could be due to neurovascular dysregulation.

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Acknowledgements

This work was supported by the Spanish Ministry of Economy and Competitiveness (grants SAF2014-56330-R and IEDI-2017-00826). This funding source did not have any role in study design, collection, analysis, interpretation of data, manuscript writing or decision to publish.

Funding

This study was funded by the Spanish Ministry of Economy and Competitiveness (grants SAF2014–56330-R and IEDI-2017-00826).

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Authors and Affiliations

  1. Department of Radiology, Clínica Universidad de Navarra, Pio XII, 36, 31008, Pamplona, Spain

    Alvaro Galiano, Reyes García de Eulate, Iñigo Galdeano, José L. Zubieta & María A. Fernández-Seara

  2. Department of Pathology, Anatomy and Physiology, School of Medicine, Universidad de Navarra, Pamplona, Spain

    Elisa Mengual

  3. Siemens Healthineers, Madrid, Spain

    Marta Vidorreta

  4. Department of Neurology, Clínica Universidad de Navarra, Pamplona, Spain

    Miriam Recio & Mario Riverol

Authors
  1. Alvaro Galiano
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  2. Elisa Mengual
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  3. Reyes García de Eulate
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  4. Iñigo Galdeano
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  5. Marta Vidorreta
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  6. Miriam Recio
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  7. Mario Riverol
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  8. José L. Zubieta
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  9. María A. Fernández-Seara
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Corresponding author

Correspondence to María A. Fernández-Seara.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Galiano, A., Mengual, E., García de Eulate, R. et al. Coupling of cerebral blood flow and functional connectivity is decreased in healthy aging. Brain Imaging and Behavior 14, 436–450 (2020). https://doi.org/10.1007/s11682-019-00157-w

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