Abstract
Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula, and amygdala are related to negative urgency, resting state functional connectivity (rsFC) of negative urgency in tobacco use has not yet been examined. This study included 34 daily tobacco users and 62 non-users matched on age, gender, race/ethnicity, and lifetime psychiatric diagnosis from a publicly available neuroimaging dataset collected by the Nathan Kline Institute-Rockland Project. Using the bilateral NAcc, insula, and amygdala as seed regions, seed-based rsFC analyses were conducted on the whole brain. In the whole sample, negative urgency was positively correlated with rsFC between the left insula and right dorsal anterior cingulate cortex (dACC). Compared to non-users, tobacco users had a stronger rsFC strength between the right amygdala and right middle temporal gyrus. In tobacco users, negative urgency was negatively associated with rsFC between the left NAcc and right dACC and between the left NAcc and right dorsolateral prefrontal cortex; these relationships were positive in non-users. Identifying functional connectivity implicated in negative urgency and tobacco use is the crucial first step to design and test pharmacological and physiological interventions to reduce negative urgency related tobacco use.
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Acknowledgements
The authors thank the Nathan Kline Institute for data sharing and Drs. Marian Logrip and Jesse Stewart for their helpful comments on an earlier draft of this manuscript. This project was based on an unpublished Master’s Thesis by the first author.
Funding
This study was funded by the National Institute on Alcoholism and Alcohol Abuse T32 grant (AA07462, PI: Czachowski) for Miji Um under the mentorship of Melissa A. Cyders and a K01 (K01AA020102, PI: Cyders). This work was also made possible through data sharing of the Rockland project by Nathan Kline Institute with support of several grants for data collection from the National Institutes of Health (NIMH BRAINS R01MH094639, PI: Milham, NIMH U01MH099059, PI: Milham; NIMH R01MH101555, PI: Craddock; NIA R01AG047596, PI: Colcombe). The listed funding agencies were not involved in study design, collection, analysis, and interpretation of the data. The opinions expressed in this manuscript are stated by the authors and do not reflect the views of listed funding agencies.
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Um, M., Hummer, T.A. & Cyders, M.A. Relationship of negative urgency to cingulo-insular and cortico-striatal resting state functional connectivity in tobacco use. Brain Imaging and Behavior 14, 1921–1932 (2020). https://doi.org/10.1007/s11682-019-00136-1
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DOI: https://doi.org/10.1007/s11682-019-00136-1