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Altered inter-hemispheric communication of default-mode and visual networks underlie etiology of primary insomnia

Altered inter-hemispheric communication underlie etiology of insomnia

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Abstract

To identify altered inter-hemispheric communication between patients with primary insomnia (PIs) and good sleepers (GSs), and their relationships with sleep and emotion-related parameters. Forty-eight PIs and 48 status-matched GSs were asked to complete a number of sleep and emotion-related questionnaires. Voxel-mirrored homotopic connectivity(VMHC) and seed-based functional connectivity were used to characterize the inter-hemispheric coordination. Seven PIs were examined twice to evaluate the test-retest reliability. Support vector machine and ROC curve were applied to discriminate the two groups. Pearson correlation and mediating causality analysis were used to describe the relationships between insomnia-related brain networks and sleep/emotion-related parameters. High test-retest stability (intraclass correlation coefficient ≥ 0.8) of the VMHC maps was observed. Intra-, and inter-hemispheric coordination dysfunctions of the default mode network, visual pathways and executive control network were found. These differences received good discriminatory power to distinguish the two groups (AUC, 0.887; sensitivity, 81.3%; specificity, 87.5%). Intra-, and inter-hemispheric communication within the default mode network and visual pathways correlated with and partially mediated the insomnia-related parameters, while the executive control network correlated with post-insomnia negative emotions. Altered inter-hemispheric coordination within the default mode network and visual pathway may be identified as core predisposing or perpetuating factors in the etiology of PIs, while the executive control network may underlie the post-insomnia negative emotional symptoms. These findings may suggest that the inter-hemispheric communication might be potential neuroimaging markers to discribe underlie neurobiological mechanism of PIs and expand our understanding of the etiology of PIs.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (grant No 81701678 and 81801315).

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  1. Xi-Jian Dai and Bi-Xia Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305#, Eastern Zhongshan Rd, Nanjing, 210002, Jiangsu, People’s Republic of China

    Xi-Jian Dai, Qiang Xu, Jianping Hu, Qirui Zhang, Yin Xu, Zhiqiang Zhang & Guangming Lu

  2. Department of Intensive Care Unit, Jiangxi Provincial Cancer Hospital, Nanchang, 330029, Jiangxi, People’s Republic of China

    Bi-Xia Liu

  3. Department of Cardiology, Heart Center, Henan Key Laboratory of Neurorestoratology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China

    Sizhi Ai

  4. Department of Radiology, Central Hospital of Yiyang, Yiyang, 413000, People’s Republic of China

    Xiao Nie

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Contributions

XJ.D., Z. Z., and G. L. conceived and designed the whole experiment; XJ.D., BX. L., and X. N. collected the data; XJ.D., SZ. A., JP. H., Q. X., QR. Z., and Y. X. take responsibility for the integrity of the data, the accuracy of the data analysis and statistical data analysis; XJ.D. and BX. L. wrote the main manuscript text; XJ.D. under took the critical interpretation of the data. All authors contributed to the final version of the paper and have read, as well as, approved the final manuscript.

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Correspondence to Zhiqiang Zhang or Guangming Lu.

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Dai, XJ., Liu, BX., Ai, S. et al. Altered inter-hemispheric communication of default-mode and visual networks underlie etiology of primary insomnia. Brain Imaging and Behavior 14, 1430–1444 (2020). https://doi.org/10.1007/s11682-019-00064-0

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