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Reduced hemispheric asymmetry of brain anatomical networks in attention deficit hyperactivity disorder

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Abstract

Despite many studies reporting a variety of alterations in brain networks in patients with attention deficit hyperactivity disorder (ADHD), alterations in hemispheric anatomical networks are still unclear. In this study, we investigated topology alterations in hemispheric white matter in patients with ADHD and the relationship between these alterations and clinical features of the illness. Weighted hemispheric brain anatomical networks were first constructed for each of 40 right-handed patients with ADHD and 53 matched normal controls. Then, graph theoretical approaches were utilized to compute hemispheric topological properties. The small-world property was preserved in the hemispheric network. Furthermore, a significant group-by-hemisphere interaction was revealed in global efficiency, local efficiency and characteristic path length, attributed to the significantly reduced hemispheric asymmetry of global and local integration in patients with ADHD compared with normal controls. Specifically, reduced asymmetric regional efficiency was found in three regions. Finally, we found that the abnormal asymmetry of hemispheric brain anatomical network topology and regional efficiency were both associated with clinical features (the Adult ADHD Self-Report Scale and Wechsler Adult Intelligence Scale) in patients. Our findings provide new insights into the lateralized nature of hemispheric dysconnectivity and highlight the potential for using brain network measures of hemispheric asymmetry as neural biomarkers for ADHD and its clinical features.

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Funding

This work was supported by the National Natural Science Foundation of China (61503272, 61503273, 61741212), the Natural Science Foundation of Shanxi (2015021090, 201601D202042) and the project funded by the China Postdoctoral Science Foundation (2016 M601287), the Shanxi Provincial Foundation for Returned Scholars, China (2016–037), the Scientific Research Foundation for Returned Overseas Chinese Scholars (20151098-2), the Key Research and Development Project in Shanxi (201603D111014), the Foundation for Youths of Taiyuan University of Technology (2015QN025).

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Authors and Affiliations

  1. College of Information and Computer, Taiyuan University of Technology, No. 79, Yingze West Street, Taiyuan, 030024, Shanxi, China

    Dandan Li, Ting Li, Yan Niu, Jie Xiang, Rui Cao & Bin Wang

  2. Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China

    Bo Liu, Hui Zhang & Bin Wang

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  1. Dandan Li
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  2. Ting Li
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  3. Yan Niu
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  4. Jie Xiang
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  5. Rui Cao
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  6. Bo Liu
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  7. Hui Zhang
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  8. Bin Wang
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Correspondence to Bin Wang.

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The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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The study was carried out in strict accordance with the University of California, Los Angeles Institutional Review Board.

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After receiving a thorough explanation, all participants gave written informed consent according to the procedures approved by the University of California Los Angeles Institutional Review Board.

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Dandan Li and Ting Li are first co-author.

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Li, D., Li, T., Niu, Y. et al. Reduced hemispheric asymmetry of brain anatomical networks in attention deficit hyperactivity disorder. Brain Imaging and Behavior 13, 669–684 (2019). https://doi.org/10.1007/s11682-018-9881-5

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