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Imaging behavioural complications of Parkinson’s disease

  • Advances in Imaging (Hadassah Conference)
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Abstract

In addition to motor symptoms, behavioural complications are commonly found in patients with Parkinson’s disease (PD). Behavioural complications, including depression, anxiety, apathy, impulse control disorder and psychosis, together have a large impact on PD patient’s quality of life. Many neuroimaging studies using PET, SPECT and MRI techniques have been conducted to study the underlying neural mechanisms of PD pathogenesis and pathophysiology in relation to its behavioural complications. This review will survey these PET, SPECT and MRI studies to describe the current understanding of the neuro-chemical, functional and structural changes associated with behavioural complications in PD patients.

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Acknowledgements

This work was supported by Canadian Institutes of Health Research (MOP 136778). A.P.S is supported by the Canada Research Chair program.

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Authors and Affiliations

  1. Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada

    Mikaeel Valli, Alexander Mihaescu & Antonio P. Strafella

  2. Division of Brain, Imaging and Behaviour – Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Toronto, ON, Canada

    Mikaeel Valli, Alexander Mihaescu & Antonio P. Strafella

  3. Institute of Medical Science, University of Toronto, Toronto, ON, Canada

    Mikaeel Valli, Alexander Mihaescu & Antonio P. Strafella

  4. Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Neurology Division, Department of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada

    Antonio P. Strafella

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  1. Mikaeel Valli
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Valli, M., Mihaescu, A. & Strafella, A.P. Imaging behavioural complications of Parkinson’s disease. Brain Imaging and Behavior 13, 323–332 (2019). https://doi.org/10.1007/s11682-017-9764-1

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