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Neural correlates of emotional valence processing in Parkinson’s disease: dysfunction in the subcortex

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Abstract

Parkinson’s disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD.

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Abbreviations

AGNG:

Affective Go-NoGo

PD:

Parkinson’s disease

VTA:

Ventral Tegmental Area

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Acknowledgements

We would like to thank Dr. Samuel J. Bolitho for assistance with data collection and Dr. Claire O’Callaghan for critical appraisal on prior versions of the manuscript. Finally, we would like to thank all of the participants and their families for their involvement in this research.

Author contributions

PTB, KLM, DAC conceptualized the study; PTB, JMS, SJGL, DAC collected the data; PTB, MG, KLM, DAC analyzed the data; PTB wrote the initial draft; PTB, MG, JMS, KLM, SJGL edited the manuscript.

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Author notes

  1. Katie L. McMahon, Simon J. G. Lewis and David A. Copland contributed equally to this work.

Authors and Affiliations

  1. Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia

    Peter T. Bell, Moran Gilat, James M. Shine & Simon J. G. Lewis

  2. University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD, Australia

    Peter T. Bell & David A. Copland

  3. Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia

    Katie L. McMahon

  4. School of Health & Rehabilitation Sciences, University of Queensland, Brisbane, QLD, Australia

    David A. Copland

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  1. Peter T. Bell
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Correspondence to Peter T. Bell.

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Funding

Funded by Australian Research Council Future Fellowship FT100100976 to DAC.

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PTB, MG, JMS, KM, SJGL, DAC declare that they have no conflict of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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Bell, P.T., Gilat, M., Shine, J.M. et al. Neural correlates of emotional valence processing in Parkinson’s disease: dysfunction in the subcortex. Brain Imaging and Behavior 13, 189–199 (2019). https://doi.org/10.1007/s11682-017-9754-3

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