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Neural correlates of the mini-SEA (Social cognition and Emotional Assessment) in behavioral variant frontotemporal dementia

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Abstract

Although Frontotemporal Dementia (FTD) is the second most common form of dementia after Alzheimer’s disease, its diagnosis remains particularly challenging today. This is particularly true for the behavioral variant (bvFTD), the most common phenotype of FTD, which is characterised by dramatic changes in personal and social conduct. Novel clinical cognitive tests have been recently proposed to diagnose and assess these patients. Among them, the mini-SEA (Social cognition & Emotional Assessment) has shown promising results. This quick clinical tool evaluates emotion recognition and theory of mind deficits, both recognized as hallmark features of bvFTD. In this study, we investigated the neural correlates of the mini-SEA in twenty bvFTD patients, using single photon emission computed tomography (SPECT) and focusing on the mPFC. Results showed that detection of faux pas during a theory of mind evaluation was related to rostral mPFC perfusion (BA 10) while recognition of emotion involved more dorsal regions within the mPFC (BA 9). As significant and early dysfunction of the mPFC has been extensively described in bvFTD, this study supports the use of the mini-SEA in evaluation and diagnosis purposes in bvFTD.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie-Curie (UPMC), INSERM UMRS 975, Paris, France

    M. Bertoux, E. Volle, L. C. de Souza & B. Dubois

  2. Centre de Référence Démences Rares, Paris, France

    M. Bertoux, A. Funkiewiez & B. Dubois

  3. INSERM, UMR-S 678, Université Pierre et Marie Curie-Paris 6, 75013, Paris, France

    M. O. Habert

  4. Institut de la Mémoire et de la Maladie d’Alzheimer, Pavillon François Lhermite, GHU Hospitalier de la Pitié-Salpêtrière, 47 boulevard de l’Hôpital., 75013, Paris, France

    M. Bertoux, E. Volle, L. C. de Souza, A. Funkiewiez & B. Dubois

  5. Service de médecine nucléaire, GHU Hospitalier de la Pitié-Salpêtrière, 47 boulevard de l’Hôpital., 75013, Paris, France

    M. O. Habert

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  1. M. Bertoux
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  2. E. Volle
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  3. L. C. de Souza
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  4. A. Funkiewiez
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  5. B. Dubois
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  6. M. O. Habert
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Correspondence to M. Bertoux.

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Bertoux, M., Volle, E., de Souza, L.C. et al. Neural correlates of the mini-SEA (Social cognition and Emotional Assessment) in behavioral variant frontotemporal dementia. Brain Imaging and Behavior 8, 1–6 (2014). https://doi.org/10.1007/s11682-013-9261-0

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  • DOI: https://doi.org/10.1007/s11682-013-9261-0

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