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Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment

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Abstract

The present study examined the relationship between entorhinal cortex and hippocampal volume with fMRI activation during episodic memory function in elderly controls with no cognitive impairment and individuals with amnesic mild cognitive impairment (aMCI). Both groups displayed limited evidence for a relationship between hippocampal volume and fMRI activation. Smaller right entorhinal cortex volume was correlated with reduced activation in left and right medial frontal cortex (BA 8) during incidental encoding for both aMCI and elderly controls. However, during recognition, smaller left entorhinal cortex volume correlated with reduced activation in right BA 8 for the control group, but greater activation for the aMCI group. There was no significant relationship between entorhinal cortex volume and activation during intentional encoding in either group. The recognition-related dissociation in structure/function relationships in aMCI paralleled our behavioral findings, where individuals with aMCI displayed poorer performance relative to controls during recognition, but not encoding. Taken together, these results suggest that the relationship between entorhinal cortex volume and fMRI activation during episodic memory function is altered in individuals with aMCI.

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Acknowledgements

This study was supported by grants from the National Institute on Aging (P01 AG09466; P30 AG10161, R01 AG017917, and T32 AG000257) and the Illinois Department of Public Health. We especially thank the participants of the Rush Alzheimer’s Disease Core Center and the Memory and Aging Project for participating in this study.

Conflict of interest

There were no actual or potential conflicts of interest in this study.

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Authors and Affiliations

  1. Department of Neurological Sciences, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL, 60612, USA

    Mehul A. Trivedi, Travis R. Stoub, Christopher M. Murphy, Sarah George, Leyla deToledo-Morrell & Glenn T. Stebbins

  2. Department of Family Medicine and Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

    Raj C. Shah

  3. Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA

    Susan Whitfield-Gabrieli & John D. E. Gabrieli

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  1. Mehul A. Trivedi
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Correspondence to Glenn T. Stebbins.

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Trivedi, M.A., Stoub, T.R., Murphy, C.M. et al. Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment. Brain Imaging and Behavior 5, 126–136 (2011). https://doi.org/10.1007/s11682-011-9117-4

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