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Risk factors of precancerous gastric lesions in a population at high risk of gastric cancer

  • Original Article
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective|

In cancer prevention, the targeting of precancerous lesions has been recognized as the most promising method. However, little attention has been paid to the risk factors of precancerous gastric lesions, especially in rural China where there is high prevalence of precancerous gastric lesions. We therefore conducted a cross-sectional study in Liaoning province, China, to investigate the potential risk and protective factors of these precancerous gastric lesions.

Methods

A total of 1,179 subjects with high risk of gastric cancer from Zhuanghe County were included in this study. Standard questionnaires were used in collecting epidemiological factors and the data were then analyzed by the unconditional logistic regression model.

Results

Smoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects, and the association of smoking or drinking and the precancerous gastric lesions increased in strength with the daily consumption and duration. As the factors such as age, gender, smoking, alcohol were controlled, a multivariable analysis revealed that there was a significant correlation between the deep-fry food intake and the gastric epithelial dysplasia with the odds ratio (OR) of 1.78 [95% confidence interval (CI): 1.01–3.12]. Garlic eating was shown to confer protection against the development of gastric ulcer (OR=0.55, 95% CI: 0.33–0.92).

Conclusion

Smoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects. Deep-fry food intake might be one of the risk factors for the precancerous gastric lesions and garlic eating was shown to confer protection against the development of gastric ulcer among rural Chinese population.

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References

  1. Sambasivaiah K, Ibrarullah M, Reddy MK, et al. Clinical profile of carcinoma stomach at a tertiary care hospital in south India[J]. Trop Gastroenterol 2004; 25: 21–26.

    CAS  PubMed  Google Scholar 

  2. Samarasam I, Chandran BS, Sitaram V, et al. Palliative gastrectomy in advanced gastric cancer: is it worthwhile[J]? ANZ J Surg 2006; 76: 60–63.

    Article  PubMed  Google Scholar 

  3. Murray CJ, Lopez AD. Alternate projections of mortality and disability by cause 1990–2020: Global burden of disease study[J]. Lancet 1997; 349: 1498–1504.

    Article  CAS  PubMed  Google Scholar 

  4. Recalling the Third National Survey on the Cause of Death[M]. Chen Zhu, Ed. Beijing: Peking Union Medical College Press 2008.

    Google Scholar 

  5. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process: First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention[J]. Cancer Res 1992; 52: 6735–6740.

    CAS  PubMed  Google Scholar 

  6. Módena JL, Acrani GO, Micas AF, et al. Correlation between Helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil[J]. Braz J Infect Dis 2007; 11:89–95.

    Article  PubMed  Google Scholar 

  7. Kim N, Park YS, Cho SI, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease[J]. Helicobacter 2008; 13: 245–255.

    Article  PubMed  Google Scholar 

  8. Yamaji Y, Watabe H, Yoshida H, et al. High-risk population for gastric cancer development based on serum pepsinogen status and lifestyle factors[J]. Helicobacter 2009; 14: 81–86.

    Article  CAS  PubMed  Google Scholar 

  9. Yuan Yuan, Zhang Yinchang. A report of prevention and control scene for gastric cancer in Zhuanghe region,Liaoning Province[J]. China Tumor 2009; 18: 14–18.

    Google Scholar 

  10. You WC, Li JY, Blot WJ, et al. Evolution of precancerous lesions in a rural Chinese population at high risk of gastric cancer[J]. Int J Cancer 1999; 83: 615–619.

    Article  CAS  PubMed  Google Scholar 

  11. Correa P. The biological model of gastric carcinogenesis[ J]. IARC Sci Publ 2004; 157: 301–310.

    PubMed  Google Scholar 

  12. You WC, Blot WJ, Li JY, Chang YS, Jin ML, Kneller R. Precancerous gastric lesions in a population at high risk of stomach cancer[J]. Cancer Res 1993; 53:1317–1321.

    CAS  PubMed  Google Scholar 

  13. Schubert ML. Gastric secretion[J]. Curr Opin Gastroenterol 2008; 24: 659–664.

    Article  PubMed  Google Scholar 

  14. Anda RF, Williamson DF, Escobedo LG. Selfperceived stress and the risk of peptic ulcer disease: a longitudinal study of US adults[J]. Arch Intern Med 1992; 152: 829–833.

    Article  CAS  PubMed  Google Scholar 

  15. La Torre G, Chiaradia G, Gianfagna F, et al. Smoking status and gastric cancer risk: an updated metaanalysis of case-control studies published in the past ten years[J]. Tumori 2009; 95:13–22.

    PubMed  Google Scholar 

  16. Shikata K, Doi Y, Yonemoto K, et al. Populationbased prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence: the Hisayama Study[J]. Am J Epidemiol 2008; 168:1409–1415.

    Article  PubMed  Google Scholar 

  17. Koivisto TT, Voutilainen ME, Färkkilä MA. Effect of smoking on gastric histology in Helicobacter pyloripositive gastritis[J]. Scand J Gastroenterol 2008; 43:1177–1183.

    Article  CAS  PubMed  Google Scholar 

  18. Saha SK. Smoking habits and carcinoma of the stomach: a case-control study[J]. Jpn J Cancer Res 1991; 82: 497–502.

    CAS  PubMed  Google Scholar 

  19. Dyke GW, Craven JL, Hall R, et al. Smoking-related DNA adducts in human gastric cancers[J]. Int J Cancer 1992; 52: 847–850.

    Article  CAS  PubMed  Google Scholar 

  20. Figueroa JD, Terry MB, Gammon MD, et al. Cigarette smoking, body mass index, gastroesophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 over-expression[ J]. Cancer Causes Control 2009; 20: 361–368.

    Article  PubMed  Google Scholar 

  21. Módena JL, Acrani GO, Micas AF, et al. Correlation between Helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil[J]. Braz J Infect Dis 2007; 11: 89–95.

    Article  PubMed  Google Scholar 

  22. Murray LJ, Lane AJ, Harvey IM. Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project[J]. Am J Gastroenterol 2002; 97: 2750–2755.

    Article  PubMed  Google Scholar 

  23. Leung WK, Wu KC, Wong CY, et al. Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice[J]. Carcinogenesis 2008; 29: 1648–1654.

    Article  CAS  PubMed  Google Scholar 

  24. Kato I, Vivas J, Plummer M, et al. Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela[J]. Cancer Epidemiol Biomarkers Prev 2004; 13: 468–476.

    PubMed  Google Scholar 

  25. Munoz N, Plummer M, Viva J. A case-control study of gastric cancer in Venezuela[J]. Int J Cancer 2001; 93: 417–423.

    Article  CAS  PubMed  Google Scholar 

  26. Fontham E, Zavala D, Correa P. Diet and chronic atrophic gastritis: a case-control study[J]. J Natl Cancer Inst 1986; 76: 621–627.

    CAS  PubMed  Google Scholar 

  27. Hamajima N, Matsuo K, Suzuki T. Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori infection[J]. Jpn J Cancer Res 2001; 92: 488–493.

    CAS  PubMed  Google Scholar 

  28. Fujimura S, Kawamura T, Kato S, et al. Detection of Helicobacter pylori in cow’s milk[J]. Lett Appl Microbiol 2002; 35: 504–507.

    Article  CAS  PubMed  Google Scholar 

  29. Dore MP, Sepulveda AR, El-Zimaity H. Isolation of Helicobacter pylori from sheep—implications for transmission to humans[J]. Am J Gastroenterol 2001; 96:1396–1401.

    CAS  PubMed  Google Scholar 

  30. Lee SY, Shin YW, Hahm KB. Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection[J]. J Dig Dis 2008; 9:129–139.

    Article  CAS  PubMed  Google Scholar 

  31. Iimuro M, Shibata H, Kawamori T. Suppressive effects of garlic extract on Helicobacter pyloriinduced gastritis in Mongolian gerbils[J]. Cancer Lett 2002; 187: 61–68.

    Article  CAS  PubMed  Google Scholar 

  32. Gail MH, Pfeiffer RM, Brown LM. Garlic, vitamin, and antibiotic treatment for Helicobacter pylori: a randomized factorial controlled trial[J]. Helicobacter 2007; 12: 575–578.

    Article  PubMed  Google Scholar 

  33. Fani A, Fani I, Delavar M. Combined garlicomeprazole versus standard quadruple therapy for eradication of Helicobacter pylori infection[J]. Indian J Gastroenterol 2007; 26: 145–146.

    CAS  PubMed  Google Scholar 

  34. You WC, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions[J]. Natl Cancer Inst 2006; 98: 974–983.

    Article  Google Scholar 

  35. Salih BA, Abasiyanik FM. Does regular garlic intake affect the prevalence of Helicobacter pylori in asymptomatic subjects[J]? Saudi Med J 2003; 24: 842–845.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Jian Liu, Li-Ping Sun, Yue-Hua Gong & Yuan Yuan

Authors
  1. Jian Liu
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  2. Li-Ping Sun
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  3. Yue-Hua Gong
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  4. Yuan Yuan
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Corresponding author

Correspondence to Yuan Yuan.

Additional information

This work was supported by the National Tenth Five-year Study Program for Taking Key Scientific Problems of China (No.2004 BA703 B06-2), and the Science Program of Liaoning Province(No. 200722501-1)

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Liu, J., Sun, LP., Gong, YH. et al. Risk factors of precancerous gastric lesions in a population at high risk of gastric cancer. Chin. J. Cancer Res. 22, 267–273 (2010). https://doi.org/10.1007/s11670-010-0267-5

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  • DOI: https://doi.org/10.1007/s11670-010-0267-5

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