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Polymorphisms of XPC gene and susceptibility of esophageal cancer

  • Original Article
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To explore the relationships of the polymorphisms of xeroderma pigmentosum C (XPC) and the susceptibility of esophageal cancer (EC) in Changzhi area, China.

Methods

The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP).

Results

The frequencies of wild homozygote (PAT−/−), mutation heterozygote (PAT−/+) and mutation homozygote (PAT+/+) of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups (χ2 =0.332, P=0.847). There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A (XPA) (S=0.85) and pickled food (S=0.81).

Conclusion

A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.

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Authors and Affiliations

  1. School of Public Health, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xiang-xian Feng & Zu-xun Lu

  2. Department of Preventive medicine, Changzhi Medical College, Changzhi, Shanxi, 046000, China

    Xiang-xian Feng, Pei-fen Duan & Li-bing Wang

Authors
  1. Xiang-xian Feng
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  2. Pei-fen Duan
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  3. Li-bing Wang
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  4. Zu-xun Lu
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Corresponding author

Correspondence to Zu-xun Lu.

Additional information

This work was supported by a grant from Scholarship Council Fund of Shanxi Province (No.200565).

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Feng, Xx., Duan, Pf., Wang, Lb. et al. Polymorphisms of XPC gene and susceptibility of esophageal cancer. Chin. J. Cancer Res. 22, 49–54 (2010). https://doi.org/10.1007/s11670-010-0049-0

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  • DOI: https://doi.org/10.1007/s11670-010-0049-0

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