Abstract
Objective
To investigate the expression of beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGF receptor-2 (VEGFR-2) protein in medulloblastoma.
Methods
Immunohistochemical staining with SP method was conducted to determine the expression of beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues.
Results
The expression rate of beta-catenin, and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. A significant positive correlation was found between beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 protein in medulloblastoma.
Conclusion
There was a correlation between beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 in medulloblastoma, which may play a role in the pathogenesis and development of medulloblastoma.
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Zhang, Hm., Zhang, X., Li, Y. et al. Relationship between expression of beta-catenin and VEGFs (VEGFA, VEGF-C), VEGF receptors-2 (VEGFR-2) in medulloblastoma. Chin. J. Cancer Res. 20, 44–48 (2008). https://doi.org/10.1007/s11670-008-0044-x
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DOI: https://doi.org/10.1007/s11670-008-0044-x