Abstract
Improving the heating capacity of magnetic nanoparticles (MNPs) for hyperthermia therapy is an important but challenging task. Through a comparative study of the inductive heating properties of spherical and cubic Fe3O4 MNPs with two distinct average volumes (∼7000 nm3 and 80,000 nm3), we demonstrate that, for small size (∼7000 nm3), the cubic MNPs heat better compared with the spherical MNPs. However, the opposite trend is observed for larger size (∼80,000 nm3). The improvement in heating efficiency in cubic small-sized MNPs (∼7000 nm3) can be attributed to enhanced anisotropy and the formation of chain-like aggregates, whereas the decrease of the heating efficiency in cubic large-sized MNPs (∼80,000 nm3) has been attributed to stronger aggregation of particles. Physical motion is shown to contribute more to the heating efficiency in case of spherical than cubic MNPs, when dispersed in water. These findings are of crucial importance in understanding the role of shape anisotropy and optimizing the heating response of magnetic nano-structures for advanced hyperthermia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
P. Pradhan, J. Giri, G. Samanta, H.D. Sarma, K.P. Mishra, J. Bellare, R. Banerjee, and D. Bahadur, J. Biomed. Mater. Res. B Appl. Biomater. 81B, 12 (2007).
R. Hergt, S. Dutz, R. Muller, and M. Zeisberger, J. Phys. Condens. Matter 18, S2919 (2006).
R.E. Rosensweig, J. Magn. Magn. Mater. 252, 370 (2002).
R. Hergt, W. Andra, C.G. d’Ambly, I. Hilger, W.A. Kaiser, U. Richter, and H.G. Schmidt, IEEE Trans. Magn. 34, 3745 (1998).
R. Hergt and S. Dutz, J. Magn. Magn. Mater. 311, 187 (2007).
R. Das, J. Alonso, Z.N. Porshokouh, V. Kalappattil, D. Torres, M.-H. Phan, E. Garaio, J.Á. García, J.L.S. Llamazares, and H. Srikanth, J. Phys. Chem. C 120, 10086 (2016).
C.M. Boubeta, K. Simeonidis, A. Makridis, M. Angelakeris, O. Iglesias, P. Guardia, A. Cabot, L. Yedra, S. Estradé, F. Peiró, Z. Saghi, P.A. Midgley, I.C. Leborán, D. Serantes, and D. Baldomir, Sci. Rep. 3, 1652 (2013).
P. Guardia, R.D. Corato, L. Lartigue, C. Wilhelm, A. Espinosa, M.G. Hernandez, F. Gazeau, L. Manna, and T. Pellegrino, ACS Nano 6, 3080 (2012).
H. Khurshid, J. Alonso, Z. Nemati, M.H. Phan, P. Mukherjee, M.L. Fdez-Gubieda, J.M. Barandiaran, and H. Srikanth, J. Appl. Phys. 117, 17A337 (2015).
Z. Nemati, J. Alonso, L.M. Martinez, H. Khurshid, E. Garaio, J.A. Garcia, M.H. Phan, and H. Srikanth, J. Phys. Chem. C 120, 8370 (2016).
D.F. Coral, P.M. Zélis, M. Marciello, M.P.O. Morales, A. Craievich, F.H. Sánchez, and M.B.F. van Raap, Langmuir 32, 1201 (2016).
J.P. Fortin, F. Gazeau, and C. Wilhelm, Eur. Biophys. 37, 223 (2008).
H. Khurshid, W. Li, S. Chandra, M.H. Phan, G.C. Hadjipanayis, P. Mukherjee, and H. Srikanth, Nanoscale 5, 7942 (2013).
S.H. Noh, W. Na, J.T. Jang, J.H. Lee, E.J. Lee, S.H. Moon, Y. Lim, J.S. Shin, and J. Cheon, Nano Lett. 12, 3716 (2012).
G.F. Goya, T.S. Berquó, F.C. Fonseca, and M.P. Morales, J. Appl. Phys. 94, 3520 (2003).
N.A. Usov and B.Y. Liubimov, J. Appl. Phys. 112, 023901 (2012).
Acknowledgements
Work was partially supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award # DE-FG02-07ER46438. H.S. acknowledges support from the Bizkaia Talent Program, Basque Country (Spain). J.A. acknowledges the financial support provided through a postdoctoral fellowship from the Basque Government.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Nemati, Z., Das, R., Alonso, J. et al. Iron Oxide Nanospheres and Nanocubes for Magnetic Hyperthermia Therapy: A Comparative Study. J. Electron. Mater. 46, 3764–3769 (2017). https://doi.org/10.1007/s11664-017-5347-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11664-017-5347-6