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Osteoporosis is associated with increased risk for benign paroxysmal positional vertigo: a nationwide population-based study

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Abstract

Summary

Recent evidence has indicated that osteoporosis is a risk factor for benign paroxysmal positional vertigo (BPPV). This large population-based study demonstrated that patients with osteoporosis had a 1.82-fold higher risk of developing BPPV than those without osteoporosis through the use of the Taiwan National Health Insurance Research Database.

Purpose

Benign paroxysmal positional vertigo (BPPV) is one of the most frequent causes of vertigo. Osteoporosis reflects a homeostatic imbalance in the rate of bone turnover, with the rate of bone resorption exceeding that of bone formation. Recent evidence has indicated that osteoporosis is a risk factor for BPPV. We aimed to validate the risk of BPPV in osteoporotic patients through a nationwide, population-based, cohort study.

Methods

Patients treated for osteoporosis were identified from entries made in the Taiwan National Health Insurance Research Database (NHIRD) between 2000 and 2013. Each osteoporosis patient was age- and sex-matched with four randomly selected subjects without osteoporosis. We compared the incidence rates of BPPV in the two cohorts (with and without osteoporosis) and identified risk factors.

Results

We identified 6649 osteoporosis patients and 26,596 match controls. According to the incidence of BPPV among the two groups, patients with osteoporosis were found to have a 1.82-fold higher risk of developing BPPV than those without osteoporosis. The incidence rate ratio (IRR) between osteoporotic patients and the control cohort was 2.0 (p < 0.001).

Conclusions

This large population-based study demonstrated that patients with osteoporosis were associated with an increased risk for BPPV. The results of this study provide some insight into the management of BPPV.

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Acknowledgements

The authors would like to thank the Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi Branch (CLRPG6G0041) for the comments and assistance in data analysis.

Funding

The study was supported by grants from CMRPG381101 from Chang Gung Memorial Hospital, Linkou, Taiwan. This study was also supported by a grant from Chang Gung Memorial Hospital, Chiayi Branch, and based on the National Health Insurance Research Database provided by the Central Bureau of National Health Insurance, the Department of Health, and managed by the National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health, or National Health Research Institutes.

Author information

Authors and Affiliations

  1. Department of Otolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kwei-Shan, Taoyuan, 333, Taiwan

    Kai-Chieh Chan & Po-Hung Chang

  2. School of Medicine, Chang Gung University, Taoyuan, Taiwan

    Kai-Chieh Chan, Yao-Te Tsai & Po-Hung Chang

  3. Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan

    Kai-Chieh Chan, Yao-Te Tsai & Po-Hung Chang

  4. Department of Otolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan

    Yao-Te Tsai

  5. Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan

    Yao-Hsu Yang

  6. Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi, Taiwan

    Yao-Hsu Yang

  7. School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Yao-Hsu Yang

  8. Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan

    Pau-Chung Chen

  9. Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    Pau-Chung Chen

Authors
  1. Kai-Chieh Chan
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  2. Yao-Te Tsai
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  3. Yao-Hsu Yang
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  4. Pau-Chung Chen
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  5. Po-Hung Chang
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Corresponding author

Correspondence to Po-Hung Chang.

Ethics declarations

Patient data are de-identified, so informed consent and institutional review board approval were not required for this study.

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Chan, KC., Tsai, YT., Yang, YH. et al. Osteoporosis is associated with increased risk for benign paroxysmal positional vertigo: a nationwide population-based study. Arch Osteoporos 12, 106 (2017). https://doi.org/10.1007/s11657-017-0403-7

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  • DOI: https://doi.org/10.1007/s11657-017-0403-7

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