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Metabolically healthy/unhealthy components may modify bone mineral density in obese people

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Abstract

Summary

Link between obesity and bone health is controversial. It seems that maybe the difference in metabolic status leads to this difference. We studied relation between metabolically healthy/unhealthy components with bone mineral density. Results showed metabolically unhealthy obesity (MUHO) phenotypes have better bone status at hip site than metabolically healthy obesity (MHO). Also, component metabolic can effect on BMD in different sites.

Purpose/Introduction

This cross-sectional study aimed to compare total BMD and L-L4 BMD in MHO and MUHO base on Karelis criteria.

Methods

We enrolled 272 Iranian obese women and men (BMI ≥ 30). According to Karelis criteria, the participants were grouped base to MHO and MUHO. The body composition and BMD were assessed for all cases. Serum HDL-C, LDL-C, total cholesterol, triglyceride (TG), fasting blood glucose, homeostatic model assessment-insulin resistance (HOMA-IR), and hypersensitive C-reactive protein (hs-CRP) levels were quantified by ELISA method.

Results

Our results demonstrate MUHO phenotype have high total BMD more than MHO (P = 0.01, CI = 0.12 to 0.21). Also, the results of logistic regression analysis showed MUHO have strongly associated with total BMD (β = −0.42, CI = − 0.31 to − 0.04, P = 0.009), but did not affected L2-L4 BMD (β = − 0.09, CI = − 0.14 to 0.08, P = 0.578); this represents that there was discordance in MUHO subjects. Our evidence implicated that HOMA-IR, high level serum TG, hs-CRP, and low level serum HDL had mediatory effect on relationship between obesity and high BMD at the hip region in MUHO subjects (P < 0.05).

Conclusion

Present evidence indicates that, could be a novel link between difference in MUH phenotype and MH phenotype with bone status. Also, component metabolic can effect on BMD in different sites.

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Abbreviations

BMI:

Body mass index

BIA:

Bioelectrical impedance analysis

BMD:

Bone mineral density

BW:

Body weight

DXA:

Dual-energy X-ray absorptiometry

FBS:

Fasting blood glucose

FFM:

Fat-free mass

FM:

Fat mass

HOMA-IR:

Homeostatic model assessment-insulin resistance

HDL:

High-density lipoprotein cholesterol

LDL:

Low-density lipoprotein cholesterol

LRM:

Linear regression models

L2-L4 BMD:

Lumbar spine (vertebrae L2-L4) bone mineral density

hs-CRP:

Hypersensitive C-reactive protein

IL-6:

Interleukin-6

IGF-I:

Insulin-like growth factor 1

MH:

Metabolically healthy

MUH:

Metabolically unhealthy

MHO:

Metabolically healthy obesity

MUHO:

Metabolically unhealthy obesity

TBW:

Total body water

Total-Chol:

Total cholesterol

Total BMD:

Hip bone mineral density

TG:

Triglyceride

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Funding

This study was supported by Osteoporosis Research Center, Endocrine Diseases and Metabolism Research Institute, Tehran University of Medical Sciences and grants of Tehran University of Medical Sciences (Grants ID: 91-02-27-18041 and 94-02-161-29547).

Author information

Authors and Affiliations

  1. Osteoporosis Research Center, Endocrine Diseases and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Atieh Mirzababaei, Leila Khorrami-nezhad & Zhila Maghbooli

  2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O.Box:14155-6117, Tehran, Iran

    Atieh Mirzababaei & Khadijeh Mirzaei

  3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Seyed Ali Keshavarz

Authors
  1. Atieh Mirzababaei
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  2. Khadijeh Mirzaei
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  3. Leila Khorrami-nezhad
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  4. Zhila Maghbooli
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  5. Seyed Ali Keshavarz
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Corresponding author

Correspondence to Khadijeh Mirzaei.

Ethics declarations

All participants provided written and informed consent forms (approved by TUMS Ethics Committee, with the following identification (91-02-27-18041-69439). The study protocol was approved by the local ethical committee of Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences.

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Mirzababaei, A., Mirzaei, K., Khorrami-nezhad, L. et al. Metabolically healthy/unhealthy components may modify bone mineral density in obese people. Arch Osteoporos 12, 95 (2017). https://doi.org/10.1007/s11657-017-0381-9

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