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Effect of Shexiang Tongxin Dropping Pills (麝香通心滴丸) on the Immediate Blood Flow of Patients with Coronary Slow Flow

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Abstract

Objective

To observe the immediate effect and safety of Shexiang Tongxin dropping pills (麝香通心滴丸, STDP) on patients with coronary slow flow (CSF), and furthermore, to explore new evidence for the use of Chinese medicine in treating ischemic chest pain.

Methods

Coronary angiography (CAG) with corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) was applied (collected at 30 frames/s). The treatment group included 22 CSF patients, while the control group included 22 individuals with normal coronary flow. CSF patients were given 4 STDP through sublingual administration, and CAG was performed 5 min after the medication. The immediate blood flow frame count, blood pressure, and heart rate of patients before and after the use of STDP were compared. The liver and kidney functions of patients were examined before and after treatments.

Results

There was a significant difference in CTFC between groups (P<0.05). The average CTFC values of the vessels with slow blood flow in CSF patients were, respectively, 49.98 ± 10.01 and 40.42 ± 11.33 before and after the treatment with STDP, a 19.13% improvement. The CTFC values (frame/s) measured before and after treatment at the left anterior descending coronary artery, left circumflex artery, and right coronary artery were, respectively, 48.00 ± 13.32 and 41.80 ± 15.38, 59.00 ± 4.69 and 50.00 ± 9.04, and 51.90 ± 8.40 and 40.09 ± 10.46, giving 12.92%, 15.25%, and 22.76% improvements, respectively. The CTFC values of vessels with slow flow before treatment were significantly decreased after treatment (P<0.05). There were no apparent changes in the heart rate, blood pressure, or liver or kidney function of CSF patients after treatment with STDP (all P>0.05).

Conclusions

The immediate effect of STDP in treating CSF patients was apparent. This medication could significantly improve coronary flow without affecting blood pressure or heart rate. Our findings support the potential of Chinese medicine to treat ischemic chest pain.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Ningbo Hosptial of Zhejiang University, Ningbo First Hospital, Ningbo, Zhejiang Province, 315010, China

    Sheng-huang Wang, Lin Chu, Zhao Xu, Hong-lin Zhou, Jiang-fei Chen & Huang-fu Ning

Authors
  1. Sheng-huang Wang
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  2. Lin Chu
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  3. Zhao Xu
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  4. Hong-lin Zhou
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  5. Jiang-fei Chen
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  6. Huang-fu Ning
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Corresponding author

Correspondence to Sheng-huang Wang.

Additional information

Supported by the Zhejiang Institute of Integrative Medicine Clinical Special Fund for Pharmacy Research (No. 2014LYK009)

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Wang, Sh., Chu, L., Xu, Z. et al. Effect of Shexiang Tongxin Dropping Pills (麝香通心滴丸) on the Immediate Blood Flow of Patients with Coronary Slow Flow. Chin. J. Integr. Med. 25, 360–365 (2019). https://doi.org/10.1007/s11655-018-2559-4

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  • DOI: https://doi.org/10.1007/s11655-018-2559-4

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