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Study on the relationship between chinese medicine constitutive susceptibility and diversity of syndrome in diabetic nephropathy

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Abstract

Objective

To explore the relationship between Chinese medicine (CM) constitutive susceptibility and syndrome diversity in diabetic nephropathy (DN).

Methods

Epidemiologic investigation on constitution adopting the “Constitution in Chinese Medicine Questionnaire” (CCMQ), and survey on syndrome type by CM syndrome scale (preliminary) were carried out in 180 DN patients. Cluster analysis on symptom items was used to determine the syndrome type, and canonical correlation analysis was used to analyze the relationship between patients’ constitution and syndrome.

Results

Baseline levels in all enrolled patients were not different statistically. Cluster analysis showed 8 syndromes existed in DN patients, namely: I, qi-yin deficiency with qistagnancy type; II, yin-yang deficiency with heat-water-blood stasis type; III, qi-yin deficiency with dampnessheat type; IV, yin-yang deficiency with blood-stasis and heat type; V, qi-yin deficiency with stagnant heat type; VI, yin-yang deficiency with inner dampness-heat stagnancy type; VII, yin deficiency with heat stagnancy type; and VIII, Kidney (Shen)-Spleen (Pi) deficiency with stagnant heat type. Correlation analysis on the 8 syndromes and the 9 constitutions showed statistical significant correlations between syndrome III and dampness-heat constitution (P=0.0001); syndrome IV and blood-stasis constitution (P=0.0001); and syndrome VII and yin-deficiency constitution (P=0.0180).

Conclusion

Certain relationship revealed between CM constitutions and syndrome types; constitution decides the disease genesis, its syndrome type and prognosis, as well as the change of syndromes.

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References

  1. Meetoo D, McGovern P, Safadi R. An epidemiological overview of diabetes across the world. Br J Nurs 2007;16:1002–1007.

    PubMed  Google Scholar 

  2. Yang WY, Lu JM, Weng JP, Jia WP, Ji LN, Xiao JZ, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090–1101.

    Article  PubMed  CAS  Google Scholar 

  3. McDonald S, Excell L, Livingston B. Appendix II, in ANZDATA (Australia and New Zealand dialysis and transplant) registry report. Peritional Dial; 2008:499–518.

    Google Scholar 

  4. Yamagata K, Iseki K, Nittak K, Imai H, Iion Y, Matsuo S, et al. Chronic kidney disease perspectives in Japan and the importance of urinalysis screening. Clin Exp Nephrol 2008;12:1–8.

    Article  PubMed  Google Scholar 

  5. Lysaght M. Maintenance dialysis population dynamics: current trends and long term implications. J Am Soc Nephrol 2002;13:37–40.

    Google Scholar 

  6. Chinese Diabetes Society of Chinese Medical Association. China guideline for diabetes preventions and treatment. Chin J Prevent Control Chron Non-communic Dis (Chin) 2004;6:46–48.

    Google Scholar 

  7. Mogensen CE. Early diabetic renal involvelent and nephropathy. Amsterdam: Elsevier Science Publishers; 1987:306.

    Google Scholar 

  8. Wang Q, Zhu YB, Xue HS, Li S. Primary compiling of constitution in Chinese medicine questionnaire. Chin J Clin Rehabilit (Chin) 2006;10(3):20–22.

    Google Scholar 

  9. Zhu YB, Wang Q, Orikasa Q. Evaluation for reliability and validity of constitution in Chinese medicine questionnaire. Chin J Behav Med Sci (Chin) 2007;16:651.

    Article  Google Scholar 

  10. Mou X, Zhou DY, Zhao JX. Exploration of the research method for Chinese medicine syndrome questionnaire of diabetic nephropathy. China J Tradit Chin Med Pharm (Chin) 2007;22:787.

    Google Scholar 

  11. Zhu YB, Wang Q, Xue HS, Orikasa Q. Preliminary assessment on performance of constitution in Chinese medicine questionnaire. Chin J Clin Rehabilit (Chin) 2006;10(3):15–17.

    Google Scholar 

  12. Wang Q. Three key problems in study of Chinese medicine constitution. J Tradit Chin Med (Chin) 2006;47:329.

    Google Scholar 

  13. Zhao Y, Tong XL, Chen L. Discussion on the relationship between evolvement of β cell function of type 2 diabetes and difference syndroms of TCM. Shandong J Tradit Chin Med (Chin) 2006;25(1):3–5.

    Google Scholar 

  14. Kuang DY. Several problems in study of constitution. J Beijing Univ Tradit Chin Med (Chin) 1986;9:18.

    Google Scholar 

  15. Jing H. Relationship between constitution and Chinese medicine syndrome. J Liaoning Coll Tradit Chin Med (Chin) 1992;6:18.

    Google Scholar 

  16. Song HP. Analysis on constitution and differentiation and treatment of Chinese medicine syndrome. Tradit Chin Med Res (Chin) 1998;11(4):11–14.

    Google Scholar 

  17. Chen JX. Significance of constitution in Chinese medicine diagnosis. Gansu Coll Tradit Chin Med (Chin) 1996;3(1):1.

    Article  CAS  Google Scholar 

  18. Wang Q. Chinese medicine constitution. Beijing: China Medical Science Press; 1995:297.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Endocrinology, Hangzhou Red-Cross Hospital, Hangzhou, 310003, China

    Xin Mou  (牟 新), Dan-yang Zhou  (周旦阳), Ying-hui Liu  (刘颖慧), Yong-bin Hu  (胡永宾), Cheng-min Shou  (寿成珉), Jia-wei Chen  (陈家炜) & Guo-ling Ma  (马国玲)

  2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 1000072, China

    Di-yi Zhou  (周迪夷) & Jin-xi Zhao  (赵进喜)

  3. Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, China

    Wen-hong Liu  (刘文洪)

Authors
  1. Xin Mou  (牟 新)
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  2. Di-yi Zhou  (周迪夷)
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  3. Wen-hong Liu  (刘文洪)
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  4. Dan-yang Zhou  (周旦阳)
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  5. Ying-hui Liu  (刘颖慧)
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  6. Yong-bin Hu  (胡永宾)
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  7. Cheng-min Shou  (寿成珉)
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  8. Jia-wei Chen  (陈家炜)
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  9. Jin-xi Zhao  (赵进喜)
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  10. Guo-ling Ma  (马国玲)
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Corresponding author

Correspondence to Guo-ling Ma  (马国玲).

Additional information

Supported by the National Natural Science Foundation of China (No.30801467, No. 81273623) and the Natural Science Foundation of Zhejiang Province (No.Y2080683)

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Mou, X., Zhou, Dy., Liu, Wh. et al. Study on the relationship between chinese medicine constitutive susceptibility and diversity of syndrome in diabetic nephropathy. Chin. J. Integr. Med. 19, 656–662 (2013). https://doi.org/10.1007/s11655-013-1411-0

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  • DOI: https://doi.org/10.1007/s11655-013-1411-0

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