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Population pharmacokinetics of naringin in total flavonoids of Drynaria Fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis

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Abstract

Objective

To evaluate the effect of covariates on the pharmacokinetic profiles of naringin in the total flavonoids of Drynaria fortunei (Kunze) J. Sm. in the Qianggu Capsule (强骨胶囊) by evaluating Chinese women with primary osteoporosis.

Methods

A total of 98 female patients from the communities of Jingshan, Beixinqiao, Jiaodaokou, Chaoyangmen, and Donghuamen in Beijing, China, aged 40 to 80 years, were included in this study. Blood samples were collected before and 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after a single oral dose of Qianggu Capsule. The concentration in blood samples from 32 patients before and 0.5, 1, 2, 3, and 4 h after drug administration were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, and full set of pharmacokinetic data was analyzed with nonlinear mixed-effect modeling (NONMEM) software. The mean of population parameters clearance (C1), central distribution volume (V), absorption rate constant (Ka1), inter-compartmental clearance (C2), peripheral distribution volume (V2) were set as parameters and estimated through base model, covariate model, and final model. Age, height, weight, blood urea nitrogen (BUN), serum creatinine (Scr), alanine transaminase (ALT), aspartate transaminase (AST), hyperlipidemia, Liver (Gan) Kidney (Shen) yin insufficiency (GSYI), Kidney (Shen) yang insufficiency (SYI) were set as covariates.

Results

The relationships between these parameters and covariates were analyzed. The results showed that C1 was the main parameter influenced by the selected covariates among the population parameters, and the relationships between the covariates and C1 were analyzed, among the selected covariates hyperlipidemia was identified as significant covariate of C1.

Conclusion

The pharmacokinetic behaviors of naringin are altered with hyperlipidemia in Chinese women with primary osteoporosis.

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References

  1. Pharmacopoeia Commission of People’s Republic of China (Chinese ed). Vol. I. Pharmacopoeia of the People’s Republic of China. Beijing: Chemical Industry Press; 2005:179–180.

    Google Scholar 

  2. Li XH, Xiong ZhL, Lu Sh, Zhang Y, Li FM. Pharmacokinetics of naringin and its metabolite naringenin in rats after oral administration of rhizoma Drynariae extract assayed by UPLC-MS/MS. Chin J Nat Med 2010;8:40–46.

    Article  CAS  Google Scholar 

  3. Su L, Liu QD. Biological activity and pharmacokinetics of Naringin. Guangzhou Univ Chin Med (Chin) 2008;2:74–80.

    Google Scholar 

  4. China Association of Medicine, 1st ed. Guideline of clinical diagnosis: subvolume of osteoporosis and born minral salt diseases. Beijing: People’s health press; 2010:1–7.

    Google Scholar 

  5. Ishii K, Furuta T, Kasuya Y. Determination of naringin and naringenin in human plasma by high-performance liquid chromatography. J Chromatogr B 1996;683:225–229.

    Article  CAS  Google Scholar 

  6. Ishii K, Furuta T, Kasuya Y. Determination of naringin and naringenin in human urine by high-performance liquid chromatography utilizing solid-phase extraction. J Chromatogr B 1997;704:299–305.

    Article  CAS  Google Scholar 

  7. Fang T, Wang T, Ma Y, Su W, Bai Y, Zhao P. A. rapid LC/MS/MS quantitation assay for naringin and itstwo metabolites in rats plasma. J Pharm Biomed Anal 2006;40:454–459.

    Article  PubMed  CAS  Google Scholar 

  8. Food and Drug Adminstration. Guidance for Industry Population Pharmacokinetics 1999.

  9. Sheiner LB, Rosenberg B, Marathe VV. Estimation of population Characteristics of pharmacokinetics parameters from routine clinical data. J Pharmacokinet Biopharm 1977;5:445–479.

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100093, China

    Jian-nong Wang  (王建农)

  2. Chinese Clinical Basic Institute, China Academy of Chinese Medical Sciences, Beijing, 100700, China

    Jun-jie Jiang  (姜俊杰), Yan-ming Xie  (谢雁鸣), Xu Wei  (魏 戌) & Jian-peng Li  (李建鹏)

  3. Department of Pharmaceutics, Third Hospital Affiliated Peking University, Beijing, 100083, China

    Jing-li Duan  (段京莉) & Xin Xiong  (熊 歆)

Authors
  1. Jian-nong Wang  (王建农)
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  2. Jun-jie Jiang  (姜俊杰)
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  3. Yan-ming Xie  (谢雁鸣)
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  4. Xu Wei  (魏 戌)
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  5. Jian-peng Li  (李建鹏)
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  6. Jing-li Duan  (段京莉)
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  7. Xin Xiong  (熊 歆)
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Corresponding author

Correspondence to Yan-ming Xie  (谢雁鸣).

Additional information

Supported by Significant Drug Research and Development in Important State Science and Technology Specific and Key Technique Research (No. 2009ZX09502-030)

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Wang, Jn., Jiang, Jj., Xie, Ym. et al. Population pharmacokinetics of naringin in total flavonoids of Drynaria Fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis. Chin. J. Integr. Med. 18, 925–933 (2012). https://doi.org/10.1007/s11655-012-1296-0

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  • DOI: https://doi.org/10.1007/s11655-012-1296-0

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