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Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension

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Abstract

Objective

To investigate the effects and safety of Western medicine combined with Chinese medicine (CM) based on syndrome differentiation in the treatment of elderly polarized hypertension (PHPT), or isolated systolic hypertension with low diastolic blood pressure (DBP).

Methods

A total of 125 elderly patients with PHPT were randomly assigned to two groups: 59 in the control group treated by Western medicine and 66 in the intervention group treated by Western medicine combined with CM treatment. Based on syndrome differentiation, the patients in the intervention group were further divided into subgroups of yang-qi deficiency and yin-qi deficiency. All subjects were treated with Western medicine of Amlodipine Besylate Tablets and Irbesartan Tablets (or Irbesartan and Hydrochlorothiazide Tablets), to decrease their systolic blood pressure (SBP) slowly to 125–135 mm Hg in 2–6 weeks. In the intervention group, Shiyiwei Shenqi Capsule (十一味参芪 胶囊) was given additionally to the subgroup of yang-qi deficiency at the dosage of 3-5 capsules, thrice a day, while Dengzhan Shengmai Capsule (灯盏生脉胶囊) was given additionally to the subgroup of yin-qi deficiency at the dosage of 2 capsules, 2-3 times per day. For all subjects, SBP, pulse pressure (PP), and DBP were measured before treatment and at the terminal of a 6-week treatment. For subjects in the intervention group, left ventricular ejection fraction (LVEF) was also recorded.

Results

After a 6-week treatment, the SBP in the two groups and the PP in the intervention group decreased significantly compared to those before treatment (P<0.05), while the PP in the control group showed no significant difference between prior and post-treatment (P>0.05). After treatment, the DBP in the control group decreased (P>0.05), while the DBP and LVEF in the intervention group showed an increase tendency although it had no statistical significance (P>0.05). When subjects in the intervention group were classified further by the course of disease, the DBP and LVEF of subjects whose course of disease were less than 2 years, increased significantly after treatment (P<0.05).

Conclusion

Western medicine combined with CM treatment based on syndrome differentiation was safer and more effective than Western medicine alone in the treatment of elderly PHPT, because it not only reduced SBP but also improved DBP, which might lower the incidence of the cardiovascular and cerebrovascular events.

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References

  1. Zhao LY. The researching status quo of systol ic hypertension in elderly people with low diastolic blood pressure. Chin Heart J (Chin) 2008;20:249–252.

    Google Scholar 

  2. Shi M, Chu SL. The relationship of low diastolic blood pressure and prognosis in elderly hypertensive patients. Foreign Med Sci (Chin) 2006;1:12–16.

    Google Scholar 

  3. Long MZ, Wang DM, Yang JM, Zhou LY. Clinical study on effect of Shenmai Injection in treating congestive heart failure. Chin J Integr Tradit West Med (Chin) 2003;23:808–810.

    Google Scholar 

  4. Xu Q, Li XL, Tong M, Lu XZ, Zhang HF, Zhou YL, et al. TNF-α and arterial compliance in essential hypertension. Chin J Hypertens (Chin) 2006;14:915–919.

    CAS  Google Scholar 

  5. Cao XB, Hu YH, Wang SW. Relationship of syndrome types with vasoactive peptides in congestive heart failure. Liaoning J Tradit Chin Med (Chin) 1999;26:441–443.

    Google Scholar 

  6. Hu CS, Gao RL, and Liu LS. Seven core principles for treatment of hypertension. Chin J Integr Tradit West Med (Chin) 2006;26:363–365.

    Google Scholar 

  7. Stokes GS. Systolic hypertension in the elderly: pushing the frontiers of therapy-a suggested new approach. J Clin Hypertens 2004;6:192–197.

    Article  Google Scholar 

  8. Xiang CG, Zhang Y, Li H. The recognition of traditional Chinese medicine for the causes and mechanism of primary hypertension. World J Intergr Tradit West Med (Chin) 2010;5:356–357.

    Google Scholar 

  9. Liu GL. Discussion on pathogenesis of deficiency qi in hypertension. Shandong J Tradit Chin Med (Chin) 2003;22:9–10.

    Google Scholar 

  10. Hu CS, Hu DY. Progress in therapeutic principles and the characteristics of strategies for treatment of hypertension and its changes in China. Chin J Integr Tradit West Med (Chin) 2007;21:380–382.

    Google Scholar 

  11. Athanase DP, Michel ES, Pierre I, Hélène S, Katia LD, Jan F, et al. Diastolic blood pressure and mortality in the elderly with cardiovascular disease. Hypertension 2007;50;172–180.

    Article  Google Scholar 

  12. Hou PH, WU XJ. The observation for the curative effect of Dengzhan Shengmai Capsules in treating vertigo of qi-yin asthenia type. Guangdong Med J (Chin) 2010;31:785–786.

    Google Scholar 

  13. Shen AN, Huang R, Wang P, Xie ZB, Bin JP, Xu DL. Association of myocardial energy expenditure level obtained from doppler echocardiography with left ventricular systolic function and remodeling in essentierteal hyptension patients. Chin J Hypertens (Chin) 2010;18:285–289.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, First Affiliated Hospital of Sun Yatsen University, Guangzhou, 510080, China

    Song-lin Chen  (陈松林) & Xiao-lian Chen  (陈霄莲)

  2. Department of Traditional Chinese Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Xiao-yun Liu  (刘小云)

  3. Department of Endocrinology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Wen-ming Xu  (徐文明)

  4. Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Wei-yi Mei  (梅卫义)

Authors
  1. Song-lin Chen  (陈松林)
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  2. Xiao-yun Liu  (刘小云)
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  3. Wen-ming Xu  (徐文明)
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  4. Wei-yi Mei  (梅卫义)
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  5. Xiao-lian Chen  (陈霄莲)
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Corresponding author

Correspondence to Song-lin Chen  (陈松林).

Additional information

Supported by the Natural Science Foundation of Guangdong Province, China (No. 0606300815

These authors contributed equally to this work

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Chen, Sl., Liu, Xy., Xu, Wm. et al. Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension. Chin. J. Integr. Med. 18, 746–751 (2012). https://doi.org/10.1007/s11655-012-1231-7

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  • DOI: https://doi.org/10.1007/s11655-012-1231-7

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