Abstract
Objective
To study the syndrome evolution law of Chinese medicine (CM) in the patients with gastric mucosal dysplasia.
Methods
Three hundred and twenty four gastric mucosal dysplasia patients with deficiency and excess correlation syndromes were enrolled by a multi-center collaboration for two years’ clinical follow-up to detect the levels of tumor supplied group of factors (TSGF) and carcino-embryonic antigen (CEA).
Results
Among the 324 cases, 29 cases turned cancer in the two years, and the canceration rate was 9.0%. The three syndromes with higher canceration rate were the damp-heat accumulating Wei (胃) syndrome concurring or combining with asthenia-cold in Pi (脾) and Wei syndrome for 16.7%; stagnation in Wei collaterals syndrome concurring or combining with asthenia of both qi and yin syndrome for 13.2%; stagnation of Gan (肝) and Wei qi syndrome concurring or combining with asthenia-cold in Pi and Wei syndrome for 8.0%, respectively. Among the three syndromes, the highest level of TSGF occurred in the former two syndromes. In the half year before carcinogenesis, the syndromes of the patients took on deficiency and excess concurrent syndromes, and the deficiency syndromes involving the qi and blood deficiency syndrome and the Shen (肾) deficiency syndrome accounting for 48.0%.
Conclusions
Gastric mucosal dyspalsia canceration syndromes took on the polymorphism of excess and deficiency concurrent syndromes and had the characteristics of deficiency syndromes involving qi and blood deficiency syndrome and Shen-yin-yang deficiency syndrome.
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References
Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet 1997;349:1269–1276.
Hu L, Lao SX, Chen WW, Wang JH. Research thinking of treatment of precancerous lesion in gastric cancer. Chin J Integr Tradit West Med (Chin) 1999;19:372–373.
Rugge M, Leandro G, Farinati F, Di Mario, Sonego F, Cassaro M, et al. Gastric epithelial dysplasia. How clinicopathologic background relates to management. Cancer 1995;76:376–382.
Wang GT, ed. Practical digestive oncology of integrative medicine. Shanghai: Shanghai Science Education Publishing House; 1995:183–185.
Yuwen Y, Shen SW, Peng N, Zhang ZL, Zheng Y. Method of database building for deficiency and excess correlation syndrome of gastric dysplasia. China Arch Tradit Chin Med (Chin) 2008;26:80–81.
Xiao SD. Lecture of digestion internal medicine. Zhengzhou: Zhengzhou University Press; 2005:55.
Zhang ZK. A clinical pathologic study on the early gastric cancer. Chin J Clin Gastroenterol (Chin) 1998;10:66.
Shen SW, Yuwen Y, Chen LY, Wang JH, Yang ZH, Liu MJ, et al. Study on the structural characteristics of deficiency and excess correlation syndrome of gastric dysplasia. China Arch Tradit Chin Med (Chin) 2008;26:1609–1610.
Ma GF, Yao HC, Hua JP, Liu J. Combined detection of serum tumor specific growth factors in diagnosis of digestive neoplasms. Tianjin Med J (Chin) 2000;28:587.
Shen SW, Yuwen Y, Chen LY, Wang JH, Yang ZH, Liu MJ, et al. Study on the structural characteristics of deficiency and excess correlation syndrome and serum tumor markers of gastric dysplasia. J Tradit Chin Med (Chin) 2009;50:541–543.
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Supported by the Natural Science Foundation of China (No. 30572383; Key Subject of Spleen-Stomach Diseases of State Administration of Traditional Chinese Medicine of the Peoples’ Republic of China
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Shen, Sw., Hui, Jp., Yuwen, Y. et al. Study on canceration law of gastric mucosal dysplasia based on syndromes of Chinese medicine. Chin. J. Integr. Med. 17, 346–350 (2011). https://doi.org/10.1007/s11655-011-0616-3
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DOI: https://doi.org/10.1007/s11655-011-0616-3