Abstract
Objective
To objectively assess the clinical efficacy and safety of a new Pulian Ointment (新普连膏, NPLO) in treating psoriasis of blood-heat syndrome of Chinese medicine.
Methods
A total of 108 patients with psoriasis of blood-heat syndrome were equally assigned, using a randomizing digital table, to the test group treated externally with NPLO and the control group treated with placebo; the medication was done using a singleblinded method twice a day. Meanwhile, all patients received by oral intake a conventional Chinese decoction for clearing heat and cooling blood; the therapeutic course was 4 weeks for both groups. The therapeutic efficacy, changes in the Psoriasis Area and Severity Index (PASI) score and various aspects of the lesion, including scaly eruption, erythema, infiltration, size, score of itching as well as adverse reactions were observed.
Results
The trial was completed in 100 patients, 51 in the test group and 49 in the control group. The remarkably effective rate was 45.10% and the total effective rate was 84.31% in the test group, which were significantly higher than those in the control group, 12.24% and 51.02%, respectively, showing a significant difference between groups (P<0.01). The test group also showed better effects in the improvement of the PASI score of the lesions and scores on erythema, infiltration, size of lesion as well as itching. No adverse event was found in either group.
Conclusion
NPLO is a Chinese remedy for the external treatment of psoriasis of the blood-heat syndrome with a reliable therapeutic efficacy and good safety.
Similar content being viewed by others
References
Zhang LX, Yang DQ, Song PH, Bai YP, You LP, Liu Y. The application of Pulian ointment in the treatment of psoriasis. J Extern Ther Tradit Chin Med (Chin) 2000;9(5):22–23.
Zhao B, ed. Clinical dermatology. 3rd ed. Nanjing: Jiangsu Science and Technology Publishing House; 2001:759–772.
Zheng XY, ed. Guiding principle of clinical research on new drugs of traditional chinese medicine. Beijing: China Medic-Pharmaceutical Sciences and Technology Publishing House; 2002:299–302.
Berth-Jones J, Grotzinger K, Rainville C, Pham B, Huang J, Daly S, et al. A study examining inter- and intrarater reliability of three scales for measuring severity of psoriasis: Psoriasis Area and Severity Index, Physician’s Global Assessment and Lattice System Physician’s Global Assessment. Br J Dermatol 2006;155:707–713.
Bai YP, Zeng JJ, Yang DQ. Causal analysis of blood heat syndrome in psoriasis vulgaris. Chin Arch Tradit Chin Med (Chin) 2007;22:537–540.
Lin HB, An Y, Lu JX, Dai XM, Lin JQ, Lin JQ. The research progress of Baikal Skullcap Root. Asia-Pacific Tradit Med (Chin) 2008;4(10):136–138.
Wang YN, Bi XL, Gu J, Gao SQ. Study on the mechanism of Baicalin in psoriasis treatment. Chin J Dermatovenerol Integr Tradit West Med (Chin) 2003;2:209–211.
Kuo CL, Chi CW, Liu TY. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett 2004;20:127–137.
Song LR, ed. Modern Chinese material medica. Beijing: People’s Medical Publishing House; 2001:142.
Xiao PG, ed. Newly compiled Chinese materia medica. Beijing: Chemical Industry Press; 2002:976–986.
Ge F, Wang XD, Wang YC. Advances in studies on medicinal Radix Arnebiae Seu Lithospermi. Chin Tradit Herbal Drugs (Chin) 2003;34(9 Supp):6–9.
Sun LY, Deng BX, Chen K, Wang H. Influence on apoptosis of zndirubin and shikonin of cultured keratinocytes. Chin J Dermvenereol (Chin) 2004;18:336–339.
Author information
Authors and Affiliations
Corresponding author
Additional information
Supported by the Funds of Capital Medicine Development Program (No. 2005-SF-3-086)
Rights and permissions
About this article
Cite this article
Zhou, N., Bai, Yp., Man, Xh. et al. Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial. Chin. J. Integr. Med. 15, 409–414 (2009). https://doi.org/10.1007/s11655-009-0409-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11655-009-0409-0