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Progress of research in treatment of hyperlipidemia by monomer or compound recipe of Chinese herbal medicine

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Abstract

Hyperlipidemia (HLP) is the No.1 risk factor for patients with atherosclerosis (AS) and is directly related to the occurrence of coronary artery disease (CAD) and cerebrovascular disease. Therefore, prevention and treatment of AS is of great importance and of practical significance in controlling the incidence and mortality of CAD. With its peculiar syndrome-dependent therapy, traditional Chinese medicine (TCM) has accumulated abundant practical experiences in this field and good clinical effects have been achieved. Chinese herbal medicine, with its particularly unique advantages and high potentials yet to be tapped, displays its huge strength in HLP prevention and treatment. The progress of studies concerning prevention and treatment of HLP by Chinese herbal medicines, in the form of monomers or compound recipes, is reviewed in this paper.

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References

  1. Wang MR, Han MX. Advances in researches on visceral pathogenesis of hyperlipidemia. Chin J Basic Med Tradit Chin Med (Chin) 2005;11(4):316–319.

    Google Scholar 

  2. Sun LY, Jiao YB, Kang GS. Study developing of hyperlipemia in etological factor and pathological mechanism. Chin J Chin Indigenous Med (Chin) 2004;32(2):70–71.

    Google Scholar 

  3. Liu HY. The study of the cure of traditional Chinese medicine on hyperlipemia. Chin Med Jilin (Chin) 2004;24(8):56–57.

    Google Scholar 

  4. Song JN. Advances in studies on the treatment of atherosclerosis with traditional Chinese medicine. Chin J Basic Med Tradit Chin Med (Chin) 2003;9(11):71–75.

    Google Scholar 

  5. Ye SL, Xie WM, Ding W, et al. Discussion of the mechanism of taditional Chinese mdicine on hyperlipemia. Chin J Integr Med Cardio/Cerebrovas Dis (Chin) 2004; 2(12): 727–729.

    Google Scholar 

  6. Kou WR. The basic and clinic research of Xuezhikang. Chin Prescrip Drug (Chin) 2005;(7):52–57.

  7. Park MY, Lee KS, Sung MK. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci 2005;26:3344–3354.

    Article  CAS  Google Scholar 

  8. Yan J, Wo XD, Fan CL, et al. Effects of total flavonoids in hawthorn leaves on PPARγ-PPRE pathway regulatory system. Chin Pharm J (Chin) 2005;40(8):625–628.

    CAS  Google Scholar 

  9. Wo XD, Cui XQ, Tang LH. Effects of curcumin on the activities of plasma lipase and the concentrations of lipids in hyperlipidemic rats induced by high lipid diet. Chin J Arterioscler (Chin) 2003;11(3): 223–226.

    CAS  Google Scholar 

  10. Dou XB, Fan CL, Hong XQ, et al. Effect of curcumin on expression of LDLR in human lymphocytes. Chin Phar J (Chin) 2005;40(13):980–983.

    CAS  Google Scholar 

  11. Fan CL, Wo XD, Luo Y, et al. Effect of curcumin on expression of human low-density lipoprotein receptors in Xenopus laevis oocyte. Chin J Integr Tradit West Med (Chin) 2005;25(5):432–435.

    CAS  Google Scholar 

  12. Fan CL, Wo XD, Qian Y, et al. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol 2006;105:251–254.

    Article  PubMed  CAS  Google Scholar 

  13. Qian Y, Fan CL, Dou XB, et al. Effect of curcumin on sterol regulating system in HEK-293. Chin Pharm Bull (Chin) 2006;22(7):828–830.

    CAS  Google Scholar 

  14. Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 2004:1345–1351.

  15. Bursill CA, Roach PD. Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. J Agric Food Chem 2006;54(5):1621–1626.

    Article  PubMed  CAS  Google Scholar 

  16. Ricketts ML, Moore DD, Banz WJ, et al. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. J Nutr Biochem 2005;6:321–330.

    Article  CAS  Google Scholar 

  17. Fan CL, Gao LP, Wo XD, et al. Effect of ligustrazine on the human scavenger receptor-AI expressed in Xenopus oocytes. Chin Pharm Bull (Chin) 2005;21(6):746–751.

    CAS  Google Scholar 

  18. Niu XL, Ichimori K, Yang X, et al. Tanshinone II-A inhibits low-density lipoprotein oxidation in vitro. Free Radic Res (Chin) 2000;33(3):305–312.

    Article  CAS  Google Scholar 

  19. Huo WQ. Study progress in treatment of artherosclerosis with Chinese herbs. Guid J Tradit Chin Med (Chin) 2005;11(11):64–66.

    Google Scholar 

  20. Lu Y. The progress of traditional Chinese medicine on artherosclerosis. Tradit Chin Med Res (Chin) 2005;18(3):61–63.

    Article  Google Scholar 

  21. Chen BJ, Pan ZQ, Su XX. Progression of hyperlipemia treated with integrated traditional Chinese and Western medicine. Modern J Integr Tradit Chin West Med (Chin) 2005;14(21):2882–2884.

    Google Scholar 

  22. Yang H. The study of Chinese herbs on hyperlipemia. Chin J Integr Med Cardio/Cerebrovasc Dis (Chin) 2004;2(1):47–48.

    Google Scholar 

  23. Chen KJ, ed. Pratical internal medicine. Beijing: Union Press of Beijing Medical University & Peking Union Medical College,1999:679–685.

    Google Scholar 

  24. Wo XD, Hong XQ, Zhao GP, et al. Effects of curcumin on the metabolism of low-density lipoprotein and lipoprotein(a). Chin Med News (Chin) 2005;20(22):15–16.

    Google Scholar 

  25. Du BJ, Xu XH, Li LZ. The clinical study of Zhikeping Capsule on hyperlipidemia. Chin J Inf Tradit Chin Med (Chin) 2004;11(9):757–759.

    Google Scholar 

  26. Zhou JQ, Xia XM, Xue ZQ, et al. Effect of Astragalus membranaceus and Radix Salviae miltiorrhizae on low-density lipoprotein receptor in rabbits. Pharmacol Clin Chin Materia Medica (Chin) 2004;20(5):5–7.

    Google Scholar 

  27. Xue ZQ, Guan SJ, Zhang JH, et al. Effect of Qidan Liquid on apolipoprotein of arteriosclerosis rabbits. Chin J Pract Chin Modern Med (Chin) 2004;17(21): 3177–3178.

    Google Scholar 

  28. Yan YH. The preparation and clinic effect of complex prescription of lowering-lipid tea. Prac Clin J Integr Tradit Chin West Med (Chin) 2003;3(2):52–53.

    Google Scholar 

  29. Cai XJ. Observation of Huazhuo Jiangzhi Dcoction in treating 80 patients with hyperlipemia. Shaanxi J Tradit Chin Med (Chin) 2004;25(2): 35–136.

    CAS  Google Scholar 

  30. Li YH, Li XC, Zheng HH, et al. Effect of Compound Xuezhiqing modified on reducing fat and anti-atheroscleorsis of rabbits with hyperlipemia. Hubei J Tradit Chin Med (Chin) 2003;25(5):8–10.

    CAS  Google Scholar 

  31. Qi CR, Ji SG. Prevention and cure atherosclerosis. Chin J Pract Chin Modern Med (Chin) 2004;17(11):1631–1632.

    Google Scholar 

  32. Han GY, Qi CR. Effects of Tongmai Jiangzhi Decoction on blood lipid and endothelium function of quail with hyperlipemia. Chin J Clin Rehabil (Chin) 2005;9(31):134–135.

    Google Scholar 

  33. Jin ZS, He JC. Influences of Jianpi Jiangzhi Lin on blood lipids in rats with hyperlipemia. Chin J Integr Tradit West Med Intens Crit Care (Chin) 2002;9(1):41–43.

    Google Scholar 

  34. Wang M, Lei GH, Wang Q. Study of the effect of Dancha Capsule in lowering blood lipid. J Chin Med Materia (Chin) 2004;27(9): 671.

    Google Scholar 

  35. Wei W, Huo JL, Zuo YF, et al. The regulating effect of Qishen Jiangzhi on blood lipid. Pharmac Clin Chin Materia Medica (Chin) 2001;17(3):30–31.

    Google Scholar 

  36. Li TC, Zhang H, Zhang FH, et al. Influence of complex prescription Qishenjiangzhiyin on expressions of intercelluar adhesion molecule-1 in the aorta of hypercholesteremia rats. Chin J Clin Pharm (Chin) 2005;14(5):282–284.

    Google Scholar 

  37. Li L, Li ZG. The preparation and clinic observation of compound Zedan Huoxue Jiangzhi Capsule. Lishizhen Med Materiae Medica Res (Chin) 2003;14(11): 676–677.

    Google Scholar 

  38. He SW, He SG, Zhao RH, et al. Effects of the compound purslane on blood lipid, apolipoprotein and hemorheology in patients with hyperlipemia. Chin J Clin Rehabil (Chin) 2005;9(31):164–166.

    Google Scholar 

  39. Liu P, Zhang JS, Zhang XZ. Effects of Guanxin Kang on liver LDLR gene expression in rats with hyperlipemia. Chin Arch Tradit Chin Med (Chin) 2003;21(9):1516–1517.

    Google Scholar 

  40. Tang KX, Wang JG, Wang FB. Effect of Xiongbitong Capsule on gene expression of LDL receptor in rats. Chin J Integr Med Cardio/Cerebrovasc Dis (Chin) 2004;2(8):464–465.

    Google Scholar 

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Authors and Affiliations

  1. Zhejiang University of Chinese Medicine, Hangzhou, 310053, China

    Xiao-bing Dou  (窦晓兵), Xing-de Wo  (沃兴德) & Chun-lei Fan  (范春雷)

Authors
  1. Xiao-bing Dou  (窦晓兵)
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  2. Xing-de Wo  (沃兴德)
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  3. Chun-lei Fan  (范春雷)
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Corresponding author

Correspondence to Xiao-bing Dou  (窦晓兵).

Additional information

Supported by the Natural Science Foundation of Zhejiang Province (No. Y204269) and Chinese Medicine Foundation of Zhejiang Province (No. 2005C004)

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Dou, Xb., Wo, Xd. & Fan, Cl. Progress of research in treatment of hyperlipidemia by monomer or compound recipe of Chinese herbal medicine. Chin. J. Integr. Med. 14, 71–75 (2008). https://doi.org/10.1007/s11655-008-0071-y

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  • DOI: https://doi.org/10.1007/s11655-008-0071-y

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