Abstract
We report a case of acute lead poisoning in an adult female who had last been exposed to lead 7 years ago. She presented with abdominal pain, knee pain, and neurological symptoms, hypertension, chronic kidney disease, and anemia with basophilic stippling and lead gum lines. Compared to during her recent pregnancy, her lead level had almost tripled in 5 months to 81 mcg/dL. Chelation therapy was initiated and improved the patient’s symptoms and lead level significantly. In the absence of any new lead exposure or other reasons for increased bone turnover, this acute lead increase was likely due to skeletal mobilization caused by increased resorption from mineralized tissue during and after her pregnancy. This case report illustrates the seriousness of long-term health effects associated with lead poisoning at a multi-organ level, even years after the initial exposure. Thus, patient care should not be limited to the acute treatment of increased lead levels, but also include prevention of increased mobilization and bone turnover and appropriate patient education. In this context, we review various aspects of lead toxicity, especially during pregnancy and lactation.
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Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Med Sci Monit. 2005;11:RA329–36.
Bellinger DC. Teratogen update: lead and pregnancy. Birth Defects Res A Clin Mol Teratol. 2005;73:409–20.
McMichael AJ, Vimpani GV, Robertson EF, Baghurst PA, Clark PD. The Port Pirie cohort study: maternal blood lead and pregnancy outcome. J Epidemiol Community Health. 1986;40:18–25.
Mann KV, Travers JD. Succimer, an oral lead chelator. Clin Pharm. 1991;10:914–22.
Saito T, Ikezoe T, Taguchi H, Miyoshi I. Plumbism. Br J Haematol. 2004;124:2.
Gordon JN, Taylor A, Bennett PN. Lead poisoning: case studies. Br J Clin Pharmacol. 2002;53:451–8.
Garza A, Vega R, Soto E. Cellular mechanisms of lead neurotoxicity. Med Sci Monit. 2006;12:RA57–65.
Zelikoff JT, Li JH, Hartwig A, Wang XW, Costa M, Rossman TG. Genetic toxicology of lead compounds. Carcinogenesis 1988;9:1727–32.
Barltrop D, Smith AM. Kinetics of lead interaction with human erythrocytes. Postgrad Med J. 1975;51:770–3.
Rabinowitz MB, Wetherill GW, Kopple JD. Kinetic analysis of lead metabolism in healthy humans. J Clin Invest. 1976;58:260–70.
Piomelli S, Rosen JF, Chisolm JJ Jr, Graef JW. Management of childhood lead poisoning. J Pediatr 1984;105:523–32.
Rosen JF, Markowitz ME, Bijur PE, et al. L-line x-ray fluorescence of cortical bone lead compared with the CaNa2EDTA test in lead-toxic children: public health implications. Proc Natl Acad Sci USA. 1989;86:685–9.
Hammond PB. The effects of chelating agents on the tissue distribution and excretion of lead. Toxicol Appl Pharmacol. 1971;18:296–310.
Aposhian HV. DMSA and DMPS-water soluble antidotes for heavy metal poisoning. Annu Rev Pharmacol Toxicol. 1983;23:193–215.
Markowitz ME, Weinberger HL. Immobilization-related lead toxicity in previously lead-poisoned children. Pediatrics. 1990;86:455–7.
Goldman RH, White R, Kales SN, Hu H. Lead poisoning from mobilization of bone stores during thyrotoxicosis. Am J Ind Med. 1994;25:417–24.
el-Sharkawi AM, Morgan WD, Cobbold S, et al. Unexpected mobilisation of lead during cisplatin chemotherapy. Lancet. 1986;2:249–50.
Silbergeld EK, Schwartz J, Mahaffey K. Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res. 1988;47:79–94.
Gulson BL, Mahaffey KR, Jameson CW, et al. Mobilization of lead from the skeleton during the postnatal period is larger than during pregnancy. J Lab Clin Med. 1998;131:324–9.
Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, et al. Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one month postpartum. Environ Health Perspect. 2004;112:926–31.
Thompson GN, Robertson EF, Fitzgerald S. Lead mobilization during pregnancy. Med J Aust. 1985;143:131.
Tellez-Rojo MM, Hernandez-Avila M, Lamadrid-Figueroa H, et al. Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am J Epidemiol. 2004;160:668–78.
Manton WI, Angle CR, Stanek KL, Kuntzelman D, Reese YR, Kuehnemann TJ. Release of lead from bone in pregnancy and lactation. Environ Res. 2003;92:139–51.
Rothenberg SJ, Kondrashov V, Manalo M, et al. Increases in hypertension and blood pressure during pregnancy with increased bone lead levels. Am J Epidemiol. 2002;156:1079–87.
Tong S, Baghurst P, McMichael A, Sawyer M, Mudge J. Lifetime exposure to environmental lead and children’s intelligence at 11–13 years: the Port Pirie cohort study. BMJ. 1996;312:1569–75.
Hu H, Tellez-Rojo MM, Bellinger D, et al. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ Health Perspect. 2006;114:1730–5.
Schnaas L, Rothenberg SJ, Flores MF, et al. Reduced intellectual development in children with prenatal lead exposure. Environ Health Perspect 2006;114:791–7.
Hopkinson JM, Butte NF, Ellis K, Smith EO. Lactation delays postpartum bone mineral accretion and temporarily alters its regional distribution in women. J Nutr. 2000;130:777–83.
Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology. 2003;14:206–12.
Han S, Pfizenmaier DH, Garcia E, et al. Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation. Environ Health Perspect. 2000;108:527–31.
Prentice A. Micronutrients and the bone mineral content of the mother, fetus and newborn. J Nutr. 2003;133:1693S–9S.
Gulson BL, Mizon KJ, Palmer JM, Korsch MJ, Taylor AJ, Mahaffey KR. Blood lead changes during pregnancy and postpartum with calcium supplementation. Environ Health Perspect. 2004;112:1499–507.
Manton WI, Angle CR, Stanek KL, Reese YR, Kuehnemann TJ. Acquisition and retention of lead by young children. Environ Res. 2000;82:60–80.
Dorea JG, Donangelo CM. Early (in uterus and infant) exposure to mercury and lead. Clin Nutr 2006;25:369–76.
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Riess, M.L., Halm, J.K. Lead Poisoning in an Adult: Lead Mobilization by Pregnancy?. J GEN INTERN MED 22, 1212–1215 (2007). https://doi.org/10.1007/s11606-007-0253-x
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DOI: https://doi.org/10.1007/s11606-007-0253-x