Skip to main content
Log in

Toward a Biopsychosocial Understanding of the Patient–Physician Relationship: An Emerging Dialogue

  • Perspectives
  • Published:
Journal of General Internal Medicine Aims and scope Submit manuscript

Complexity theory has been used to view the patient–physician relationship as constituted by complex responsive processes of relating. It describes an emergent, psychosocial relational process through which patients and physicians continually and reciprocally influence each other’s behavior and experience. As psychosocial responses are necessarily biopsychosocial responses, patients and physicians must likewise be influencing each other’s psychobiology. This mutual influence may be subjectively experienced as empathy, and may be skillfully employed by the clinician to directly improve the patient’s psychobiology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Balint M. The Doctor, His Patient, and The Illness New York: International Universities Press; 1957.

    Google Scholar 

  2. Peabody F. The care of the patient. JAMA. 1927;88:877–82.

    Google Scholar 

  3. Suchman AL. A new theoretical foundation for relationship-centered care. Complex responsive processes of relating. J Gen Intern Med. 2006;21(suppl 1):S40–4.

    PubMed  Google Scholar 

  4. Kandel ER, Squire LR. Neuroscience: breaking down scientific barriers to the study of brain and mind. Science. 2000;290(5494):1113–20.

    PubMed  CAS  Google Scholar 

  5. DiMascio A, Boyd R, Greenblatt M, Solomon H. The psychiatric interview: a sociophysiologic study. Dis Nerv Syst. 1955;16:4–9.

    CAS  Google Scholar 

  6. Waid WM. Origins of sociophysiology. In: Waid WM, ed. Sociophysiology. New York,: Springer-Berlin Heidelberg New York; 1984:3–20.

    Google Scholar 

  7. Mendoza SP. Sociophysiology of well-being in nonhuman primates. Lab Anim Sci. 1991;41(4):344–9.

    PubMed  CAS  Google Scholar 

  8. Siegel D. Toward an interpersonal neurobiology of the developing mind: attachment relationships, “mindsight,” and neural integration. Infant Ment Health J. 2001;22(1–2):67–94.

    Google Scholar 

  9. Stern D. The Interpersonal World of the Infant: a View from Psychoanalysis and Developmental Psychology. New York: Basic Books; 1985.

    Google Scholar 

  10. Levenson R, Ruef A. Physiological aspects of emotional knowledge and rapport. In: Ickes W, ed. Empathic Accuracy. New York: The Guilford Press; 1997:44–72.

    Google Scholar 

  11. Rizzolatti G, Craighero L. The mirror–neuron system. Ann Rev Neurosci. 2004;27:169–92.

    PubMed  CAS  Google Scholar 

  12. Carr L, Iacoboni M, Dubeau MC, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci USA. 2003;100(9):5497–502.

    PubMed  CAS  Google Scholar 

  13. Gallese V. The roots of empathy: the shared manifold hypothesis and the neural basis of intersubjectivity. Psychopathology. 2003;36(4):171–180.

    PubMed  Google Scholar 

  14. DiMascio A, Boyd R, Greenblatt M. Physiological correlates of tension and antagonism during psychotherapy: a study of “interpersonal physiology.” Psychosom Med. 1957;19:99–104.

    PubMed  CAS  Google Scholar 

  15. Malmo RB, Boag TJ, Smith AA. The physiological study of personal interaction. Psychosom Med. 1957;19:105–19.

    PubMed  CAS  Google Scholar 

  16. Robinson J, Herman A, Kaplan B. Autonomic responses correlate with counselor–client empathy. J Couns Psychol. 1982;29:195–8.

    Google Scholar 

  17. Levenson RW, Ruef AM. Empathy: a physiological substrate. J Pers Soc Psychol. 1992;63(2):234–46.

    PubMed  CAS  Google Scholar 

  18. Levenson RW, Gottman JM. Marital interaction: physiological linkage and affective exchange. J Pers Soc Psychol. 1983;45(3):587–97.

    PubMed  CAS  Google Scholar 

  19. Barchas P, Jose II W, Payne B, Harris W. An attention-regulating function of social hierarchies: high status, attention, and the CNV brain wave. In: Barchas P, ed. Social Hierarchies: Essays Toward a Sociophysiological Perspective. Westport, CT: Greenwood Press; 1984:133–46.

    Google Scholar 

  20. Mendoza S. The psychobiology of social relationships. In: Barchas P, Mendoza S, eds. Social Cohesion: Essays Toward a Sociophysiological Perspective. Westport, Connecticut: Greenwood Press; 1984:3–30.

    Google Scholar 

  21. Gust DA, Gordon TP, Brodie AR, McClure HM. Behavioral and physiological response of juvenile sooty mangabeys to reunion with their mothers following a year’s absence. Dev Psychobiol. 1992;25(8):613–22.

    PubMed  CAS  Google Scholar 

  22. McKinney WT. Animal research and its relevance to psychiatry 1. In: Kaplan HI, Saddock BJ, eds. Comprehensive Textbook of Psychiatry. Vol. 1. Baltimore: Williams & Wilkins; 1995:397–411.

    Google Scholar 

  23. Insel TR, Hulihan TJ. A gender-specific mechanism for pair bonding: oxytocin and partner preference formation in monogamous voles. Behav Neurosci. 1995;109:782–9.

    PubMed  CAS  Google Scholar 

  24. Haber S, Barchas P. The regulatory effect of social rank on behavior after amphetamine administration. In: Barchas P, ed. Social Hierarchies, Essays Toward a Sociphysiological Perspective. Wesport, Connecticut: Greenwood Press; 1984:119–32.

    Google Scholar 

  25. Gust DA, Gordon TP, Wilson ME, Ahmed-Ansari A, Brodie AR, McClure HM. Formation of a new social group of unfamiliar female rhesus monkeys affects the immune and pituitary adrenocortical systems. Brain Behav Immun. 1991;5(3):296–307.

    PubMed  CAS  Google Scholar 

  26. Darney KJ Jr Goldman J, Vandenbergh J. Neuroendocrine responses to social regulation of puberty in the female house mouse. Neuroendocrinology. 1992;55(4):434–43.

    PubMed  CAS  Google Scholar 

  27. Dunlap JL, Zadina JE, Gougis G. Prenatal stress interacts with prepuberal social isolation to reduce male copulatory behavior. Physiol & Behav. 1978;21:(873–5).

    CAS  Google Scholar 

  28. Virgin CJ Jr, Sapolsky RM. Styles of male social behavior and their endocrine correlates among low-ranking baboons. Am J Primatol. 1997;42(1):25–39.

    PubMed  CAS  Google Scholar 

  29. Sachs BD, Akasofu K, Citron JH, Daniels SB, Natoli JH. Noncontact stimulation from estrous females evokes penile erection in rats. Physiol Behav. 1994;55(6):1073–9.

    PubMed  CAS  Google Scholar 

  30. Gardner R Jr. Sociophysiology as the basic science of psychiatry. Theor Med. 1997;18(4):335–56.

    PubMed  Google Scholar 

  31. Stern D. The Present Moment in Psychotherapy and Everyday Life New York: WW Norton & Co; 2004.

    Google Scholar 

  32. Siegel D. The Developing Mind: Toward a Neurobiology of Interpersonal Experience New York: Guilford Press; 1999.

    Google Scholar 

  33. Eisenberg L. The social construction of the human brain. Am J Psychiatry. 1995;152:1563–75.

    PubMed  CAS  Google Scholar 

  34. Kandel ER. Psychotherapy and the single synapse: the impact of psychiatric thought on neurobiologic research. N Eng J Med. 1979;301(19):1028–37.

    Article  CAS  Google Scholar 

  35. Greenough W, Black J. Induction of brain structure by experience: substrates for cognitive development. In: Gunnar M, Nelson C, eds. Minnesota Symposia on Child Psychology: Developmental Neuroscience. Vol. 24. Hillsdale, NJ: Lawrence Erlbaum; 1992.

    Google Scholar 

  36. Insel T. A neurological basis of social attachment. Am J Psychiatry. 1997;154:726–35.

    PubMed  CAS  Google Scholar 

  37. Nelso E, Panksepp J. Brain substrates of infant–mother attachment: contributions of opioids, oxytocin, and norepinephrine. Neurosci Biobehav Rev. 1998;22(3):437–52.

    Google Scholar 

  38. Young LJ, Wang Z, Insel TR. Neuroendocrine bases of monogamy. Trends Neurosci. 1998;21(2):71–5.

    PubMed  CAS  Google Scholar 

  39. Hofer MA. Relationships as regulators: a psychobiologic perspective on bereavement. Psychosom Med. 1984;46:183–97.

    PubMed  CAS  Google Scholar 

  40. Hofer MA. The Roots of Human Behavior, An Introduction to the Psychobiology of Early Development 2 San Francisco: W. N. Freeman; 1981.

    Google Scholar 

  41. Hofer MA. On the nature and consequences of early loss. Psychosom Med. 1996;58(6):570–81.

    PubMed  CAS  Google Scholar 

  42. Beebe B, Alson D, Jaffe J, Feldstein S, Crown C. Vocal congruence in mother–infant play. J Psycholinguist Res. 1988;17(3):245–59.

    PubMed  CAS  Google Scholar 

  43. Tronick ED, Als H, Brazelton, TB. Mutuality in mother–infant interaction. J Commun. 1977;27:74–9.

    PubMed  CAS  Google Scholar 

  44. Cohn J, Tronick E. Mother–infant face-to-face interaction: influence is bidirectional and unrelated to periodic cycles in either partner’s behavior. Dev Psychol. 1988;24:386–92.

    Google Scholar 

  45. Jaffe J, Beebe B, Feldstein S, Crown CL, Jasnow MD. Rhythms of dialogue in infancy: coordinated timing in development. Monogr Soc Res Child Dev. 2001;66(2):i–viii, 1–132.

    Google Scholar 

  46. Jonsson CO, Clinton DN, Fahrman M, Mazzaglia G, Novak S, Sorhus K. How do mothers signal shared feeling-states to their infants? An investigation of affect attunement and imitation during the first year of life. Scand J Psychol. 2001;42(4):377–81.

    PubMed  CAS  Google Scholar 

  47. Schore AN. Early organization of the nonlinear right brain and development of a predisposition to psychiatric disorders. Dev Psychopathol. 1997;9(4):595–631.

    PubMed  CAS  Google Scholar 

  48. Faude J, Jones C, Robins M. The affective life of infants: empirical and theoretical foundations. In: Nathanson D, ed. Knowing Feeling, Affect, Script, and Psychotherapy. New York: WW Norton & Co; 1996:219–56.

    Google Scholar 

  49. Bowlby J. A Secure Base New York: Basic Books; 1988.

    Google Scholar 

  50. Murray AD. Infant crying as an elicitor of parental behavior: an examination of two models. Psychol Bull. 1979;86:191–215.

    PubMed  CAS  Google Scholar 

  51. Meltzoff AN, Moore MK. Newborn infants imitate adult facial gestures. Child Dev. 1983;54(3):702–9.

    PubMed  CAS  Google Scholar 

  52. Rizzolatti G, Fadiga L, Fogassi L, Gallese V. From mirror neurons to imitation: facts and speculations. In: Meltzoff A, Prinz W, eds. The Imitative Mind: Development, Evolution, and Brain Bases. Cambridge Studies in Cognitive Perceptual Development. New York, NY: Cambridge University Press; 2002:247–66.

    Google Scholar 

  53. Gallese V, Fadiga L, Fogassi L, Rizzolatti G. Action recognition in the premotor cortex. Brain. 1996;119(Pt 2):593–609.

    PubMed  Google Scholar 

  54. Rizzolatti G, Fadiga L, Gallese V, Fogassi L. Premotor cortex and the recognition of motor actions. Brain Res Cogn Brain Res. 1996;3(2):131–41.

    PubMed  CAS  Google Scholar 

  55. Fadiga L, Fogassi L, Pavesi G, Rizzolatti G. Motor facilitation during action observation: a magnetic stimulation study. J Neurophysiol. 1995;73(6):2608–11.

    PubMed  CAS  Google Scholar 

  56. Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Cortical mechanisms of human imitation. Science. 1999;286(5449):2526–8.

    PubMed  CAS  Google Scholar 

  57. Fogassi L. Evolution of language from action understanding. The International Conference on Audio–Visual Speech Processing. St. Jorioz, France; 2003.

  58. Buccino G, Binkofski F, Fink G,et al. Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study. Eur J Neurosci. 2001;13(2):400–4.

    PubMed  CAS  Google Scholar 

  59. Bremmer F, Schlack A, Shah N, et al. Polymodal motion processing in posterior parietal and premotor cortex: a human fMRI study strongly implies equivalencies between humans and monkeys. Neuron. 2001;29:287–96.

    PubMed  CAS  Google Scholar 

  60. Fecteau S, Carmant L, Tremblay C, Robert M, Bouthillier A, Theoret H. A motor resonance mechanism in children? Evidence from subdural electrodes in a 36-month-old child. Neuroreport. 2004;15(17):2625–7.

    PubMed  CAS  Google Scholar 

  61. Iacoboni M. Understanding others: Imitation, language, empathy. In: Hurley S, Chater N, eds. Perspective on Imitation: From Neurons to Memes. Vol. 1: Mechanisms of Imitation and Imitation in Animals. Cambridge, MA: MIT Press; 2003.

    Google Scholar 

  62. Rizzolatti G, Fadiga L, Fogassi L, Gallese V. Resonance behaviors and mirror neurons. Arch Ital Biol. 1999;137(2–3):85–100.

    PubMed  CAS  Google Scholar 

  63. Leslie K, Johnson-Frey S, Grafton S. Functional imaging of face and hand imitation: towards a motor theory of empathy. Neuroimage. 2004;21(2):601–7.

    PubMed  Google Scholar 

  64. Shamay-Tsoorya SG, Lester H, Chisin R, et al. The neural correlates of understanding the other’s distress: a positron emission tomography investigation of accurate empathy. NeuroImage. 2005;27(2):468–72.

    Google Scholar 

  65. Vanderpool JP, Barratt ES. Empathy: towards a psychophysiological definition. Dis Nerv Syst. 1970;31(7):464–7.

    PubMed  CAS  Google Scholar 

  66. Gottman JM, Levenson RW. A valid procedure for obtaining self-report of affect in marital interaction. J Consult Clin Psychol. 1985;53(2):151–60.

    PubMed  CAS  Google Scholar 

  67. Hojat M, Gonnella JS, Nasca TJ, Mangione S, Vergare M, Magee M. Physician empathy: definition, components, measurement, and relationship to gender and specialty. Am J Psychiatry. 2002;159:1563–9.

    PubMed  Google Scholar 

  68. Eisenberg N, Fabes R. Empathy: Conceptualization, measurement, and relation to prosocial behavior. Motivation and Emotion. 1990;14(2):131–50.

    Google Scholar 

  69. Halpern J. Empathy: using resonance emotions in the service of curiosity. In: Spiro H, Cunen M, Peschel E, St James D, eds. Empathy and the Practice of Medicine: Beyond Pills and Scalpel. New Haven, CT: Yale University Press; 1993:160–73.

    Google Scholar 

  70. Orlinksy D, Grawe K, Parks B. Process and outcome in psychotherapy—noch einmal. In: Bergn A, Garfield S, eds. Handbook of Psychotherapy and Behavior. 4th ed. New York: Wiley; 1994:270–378.

    Google Scholar 

  71. Larson EB, Yao X. Clinical empathy as emotional labor in the patient–physician relationship. JAMA. 2005;249(9):1100–6.

    Google Scholar 

  72. Simpson J, Rholes W. Stress and secure base relationships in adulthood. Adv Pers Rel. 1994;5:181–204.

    Google Scholar 

  73. Spiegel D, Hunt T, Dondershine HE. Dissociation and hypnotizability in posttraumatic stress disorder. Am J Psychiatry. 1988;145(3):301–5.

    PubMed  CAS  Google Scholar 

  74. Miller WR. Rediscovering fire: small interventions, large effects. Psychol Addictive Behav. 2000;14(1):6–18.

    CAS  Google Scholar 

  75. Coulehan JL, Platt FW, Egener B, et al. Let me see if I have this right...: words that help build empathy. Ann Intern Med. 2001;135(3):221–7.

    PubMed  CAS  Google Scholar 

  76. Stacey R. Organizational identity: the paradox of continuity and potential transformation at the same time. Group Analysis. 2005;38(4):477–94.

    Google Scholar 

  77. Porges SW. Love: an emergent property of the mammalian autonomic nervous system. Psychoneuroendocrinology. 1998;23(8):837–61.

    PubMed  CAS  Google Scholar 

  78. Carter CS. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology. 1998;23(8):779–818.

    PubMed  CAS  Google Scholar 

  79. McEwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44.

    PubMed  CAS  Google Scholar 

  80. Schore A. Early relational trauma, disorganized attachment, and the development of a predisposition to violence. In: Solomon M, Siegel D, eds. Healing Trauma. New York: WW Norton & Company; 2003:107–67.

    Google Scholar 

  81. Ziskind E. The social context of nonverbal behavior. In: Philippot P, Feldman R, Coats E, eds. Infant and Child Development. New York, NY: Cambridge University Press; 1999.

    Google Scholar 

  82. Stern D. The early differentiation of self and other. In: Kaplan S, Lichtenberg J, eds. Reflections on Self Psychology. Hillsdale, NJ: Analytic Press; 1983.

    Google Scholar 

  83. Sroufe L. Emotional Development: The Organization of Emotional Life in the Early Years New York: Cambridge University Press; 1996.

    Google Scholar 

  84. Feldman R, Greenbaum CW, Yirmiya N. Mother–infant affect synchrony as an antecedent of the emergence of self-control. Dev Psychol. 1999;35(1):223–31.

    PubMed  CAS  Google Scholar 

  85. Matthews DA, Suchman AL, Branch WT Jr. Making “connexions”: Enhancing the therapeutic potential of patient–clinician relationships. Ann Intern Med. 1993;118(12):973–7.

    PubMed  CAS  Google Scholar 

  86. Berkman LF, Glass T, Brissette I, Seeman TE. From social integration to health: Durkheim in the new millennium. Soc Sci Med. 2000;51:843–57.

    PubMed  CAS  Google Scholar 

  87. Chopra SS, Sotile WM, Sotile MO. Physician burnout. JAMA. 2004;291(5):633.

    PubMed  CAS  Google Scholar 

  88. Maslach C, Schaufeli WB, Leiter MP. Job burnout. Annu Rev Psychol. 2001;52:397–422.

    PubMed  CAS  Google Scholar 

  89. Horowitz CR, Suchman AL, Branch WT Jr, Frankel RM. What do doctors find meaningful about their work? Ann Intern Med. 2003;138(9):772–5.

    PubMed  Google Scholar 

  90. Roter DL, Frankel RM, Hall JA, Sluyter D. The expression of emotion through nonverbal behavior in medical visits: mechanisms and outcomes. J Gen Intern Med. 2006;21(suppl 1):S28–34.

    PubMed  Google Scholar 

  91. Levine S, Lyons DM, Schatzberg AF. Psychobiological consequences of social relationships. Ann N Y Acad Sci. 1997;807:210–8.

    PubMed  CAS  Google Scholar 

  92. Hauck FR, Zyzanski SJ, Alemagno SA, Medalie JH. Patient perceptions of humanism in physicians: effects on positive health behaviors. Fam Med. 1990;22(6):447–52.

    PubMed  CAS  Google Scholar 

  93. Seeman TE, Crimmins E. Social environment effects on health and aging: integrating epidemiologic and demographic approaches and perspectives. Ann NY Acad Sci. 2001;954:88–117.

    Article  PubMed  CAS  Google Scholar 

  94. Cobb S. Social support as a moderator of life stress. Psychosom Med. 1976;38(5):300–14.

    PubMed  CAS  Google Scholar 

  95. Smith TW, Ruiz JM. Psychosocial influences on the development and course of coronary heart disease: current status and implications for research and practice. J Consult Clin Psychol. 2002;70(3):548–68.

    PubMed  Google Scholar 

  96. Vitetta L, Anton B, Cortizo F, Sali A. Mind-body medicine: stress and its impact on overall health and longevity. Ann NY Acad Sci. 2005;1057:492–505.

    Google Scholar 

  97. Kiecolt-Glaser J, Newton T, Cacioppo JT, MacCallum RC, Glaser R, Malarkey WB. Marital conflict and endocrine function: are men really more physiologically affected than women? J Consult Clin Psychol. 1996;64(2):324–32.

    PubMed  CAS  Google Scholar 

  98. Kiecolt-Glaser JK, Malarkey W, Chee M, et al. Negative behavior during marital conflict is associated with immunological down-regulation. Psychosom Med. 1993;55(5):395–409.

    PubMed  CAS  Google Scholar 

  99. Kandel E. Cellular mechanisms of learning and the biological basis of individuality. In: Kandel E, Schwartz J, Jessell T, eds. Principles of Neural Science. 4th edn. New York: McGraw-Hill; 2000:1247–79.

    Google Scholar 

  100. Marci CD, Moran EK, Orr SP. Physiologic evidence for the interpersonal role of laughter during psychotherapy. J Nerv Ment Dis. 2004;192(10):689–95.

    PubMed  Google Scholar 

  101. Barrett-Leonard G. The relationship inventory now: issues and advances in theory, method, and use. In: Greenberg L, Pinsoff W, eds. The Psychotherapeutic Process: A Research Handbook. New York: Guilford; 1986:439–76.

    Google Scholar 

  102. Kiecolt-Glaser JK, Glaser R, Cacioppo JT, et al. Marital conflict in older adults: endocrinological and immunological correlates. Psychosom Med. 1997;59(4):339–49.

    PubMed  CAS  Google Scholar 

  103. Novack DH, Suchman AL, Clark W, Epstein RM, Najberg E, Kaplan C. Calibrating the physician: personal awareness and effective patient care. JAMA. 1997;278(6):502–9.

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

I acknowledge with gratitude the critical readings provided by Richard L. Epstein, MD, MPH, Fred W. Markham, Jr., MD, Robert L. Perkel, MD, and Howard K. Rabinowitz, MD, the editorial assistance of Jennifer Kearney-Strouse, ELS, and Richard M. Frankel, PhD for the emergent dialogue that contributed to this paper.

Potential Financial Conflict of Interest

None disclosed.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Herbert M. Adler MD, PhD, Clinical Professor.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Adler, H.M. Toward a Biopsychosocial Understanding of the Patient–Physician Relationship: An Emerging Dialogue. J GEN INTERN MED 22, 280–285 (2007). https://doi.org/10.1007/s11606-006-0037-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11606-006-0037-8

Key words

Navigation