Abstract
Objective
We sought to determine if laparoscopic pancreatoduodenectomy (LPD) is a cost-effective alternative to open pancreatoduodenectomy (OPD).
Methods
Hospital cost data, discharge disposition, readmission rates, and readmission costs from periampullary cancer patient cohorts of LPD and OPD were compared. The surgical cohorts over a 40-month period were clinically similar, consisting of 52 and 50 patients in the LPD and OPD groups, respectively.
Results
The total operating room costs were higher in the LPD group as compared to the OPD group (median US$12,290 vs US$11,299; P = 0.05) due to increased costs for laparoscopic equipment and regional nerve blocks (P ≤ 0.0001). Although hospital length of stay was shorter in the LPD group (median 7 vs 8 days; P = 0.025), the average hospital cost was not significantly decreased compared to the OPD group (median $28,496 vs $28,623). Surgery-related readmission rates and associated costs did not differ between groups. Compared to OPD patients, significantly more LPD patients were discharged directly home rather than to other healthcare facilities (88% vs 72%; P = 0.047).
Conclusion
For the index hospitalization, the cost of LPD is equivalent to OPD. Total episode-of-care costs may favor LPD via reduced post-hospital needs for skilled nursing and rehabilitation.
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References
Alsfasser G, Hermeneit S, Rau BM, Klar E. Minimally Invasive Surgery for Pancreatic Disease - Current Status. Digestive surgery. 2016;33(4):276–83. doi:10.1159/000445007.
Correa-Gallego C, Dinkelspiel HE, Sulimanoff I, Fisher S, Vinuela EF, Kingham TP, Fong Y, DeMatteo RP, D’Angelica MI, Jarnagin WR, Allen PJ. Minimally-invasive vs open pancreaticoduodenectomy: systematic review and meta-analysis. Journal of the American College of Surgeons. 2014;218(1):129–39. doi:10.1016/j.jamcollsurg.2013.09.005.
Doula C, Kostakis ID, Damaskos C, Machairas N, Vardakostas DV, Feretis T, Felekouras E. Comparison Between Minimally Invasive and Open Pancreaticoduodenectomy: A Systematic Review. Surgical laparoscopy, endoscopy & percutaneous techniques. 2016;26(1):6–16. doi:10.1097/sle.0000000000000228.
Nappo G, Perinel J, El Bechwaty M, Adham M. Minimally Invasive Pancreatic Resection: Is It Really the Future? Digestive surgery. 2016;33(4):284–9. doi:10.1159/000445012.
Boggi U, Amorese G, Vistoli F, Caniglia F, De Lio N, Perrone V, Barbarello L, Belluomini M, Signori S, Mosca F. Laparoscopic pancreaticoduodenectomy: a systematic literature review. Surgical endoscopy. 2015;29(1):9–23. doi:10.1007/s00464-014-3670-z.
Speicher PJ, Nussbaum DP, White RR, Zani S, Mosca PJ, Blazer DG, III, Clary BM, Pappas TN, Tyler DS, Perez A. Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy. Annals of surgical oncology. 2014;21(12):4014–9. doi:10.1245/s10434-014-3839-7.
Mesleh MG, Stauffer JA, Bowers SP, Asbun HJ. Cost analysis of open and laparoscopic pancreaticoduodenectomy: a single institution comparison. Surgical endoscopy. 2013;27(12):4518–23. doi:10.1007/s00464-013-3101-6.
Delitto D, Luckhurst CM, Black BS, Beck JL, George TJ, Jr., Sarosi GA, Thomas RM, Trevino JG, Behrns KE, Hughes SJ. Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2016;20(7):1343–9. doi:10.1007/s11605-016-3136-9.
Asbun HJ, Stauffer JA. Laparoscopic vs open pancreaticoduodenectomy: overall outcomes and severity of complications using the Accordion Severity Grading System. Journal of the American College of Surgeons. 2012;215(6):810–9. doi:10.1016/j.jamcollsurg.2012.08.006.
Croome KP, Farnell MB, Que FG, Reid-Lombardo KM, Truty MJ, Nagorney DM, Kendrick ML. Total laparoscopic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: oncologic advantages over open approaches? Annals of surgery. 2014;260(4):633–8; discussion 8-40. doi:10.1097/sla.0000000000000937.
Zhang H, Wu X, Zhu F, Shen M, Tian R, Shi C, Wang X, Xiao G, Guo X, Wang M, Qin R. Systematic review and meta-analysis of minimally invasive versus open approach for pancreaticoduodenectomy. Surgical endoscopy. 2016;30(12):5173–84. doi:10.1007/s00464-016-4864-3.
Stauffer JA, Coppola A, Villacreses D, Mody K, Johnson E, Li Z, Asbun HJ. Laparoscopic versus open pancreaticoduodenectomy for pancreatic adenocarcinoma: long-term results at a single institution. Surgical endoscopy. 2016. doi:10.1007/s00464-016-5222-1.
Tan CL, Zhang H, Peng B, Li KZ. Outcome and costs of laparoscopic pancreaticoduodenectomy during the initial learning curve vs laparotomy. World journal of gastroenterology. 2015;21(17):5311–9. doi:10.3748/wjg.v21.i17.5311.
Zureikat AH, Breaux JA, Steel JL, Hughes SJ. Can laparoscopic pancreaticoduodenectomy be safely implemented? Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2011;15(7):1151–7. doi:10.1007/s11605-011-1530-x.
Delitto D, Black BS, Cunningham HB, Sliesoraitis S, Lu X, Liu C, Sarosi GA, Thomas RM, Trevino JG, Hughes SJ, George TJ, Jr., Behrns KE. Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer. American journal of surgery. 2016;212(2):195–201.e1. doi:10.1016/j.amjsurg.2016.03.001.
Fox AM, Pitzul K, Bhojani F, Kaplan M, Moulton CA, Wei AC, McGilvray I, Cleary S, Okrainec A. Comparison of outcomes and costs between laparoscopic distal pancreatectomy and open resection at a single center. Surgical endoscopy. 2012;26(5):1220–30. doi:10.1007/s00464-011-2061-y.
Tempero MA, Malafa MP, Behrman SW, Benson AB, III, Casper ES, Chiorean EG, Chung V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Lowy AM, Ma WW, Merchant NB, Mulvihill SJ, Muscarella P, II, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer SP, Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. Journal of the National Comprehensive Cancer Network : JNCCN. 2014;12(8):1083–93.
Hughes SJ, Neichoy B, Behrns KE. Laparoscopic intussuscepting pancreaticojejunostomy. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2014;18(1):208–12. doi:10.1007/s11605-013-2308-0.
Pecorelli N, Nobile S, Partelli S, Cardinali L, Crippa S, Balzano G, Beretta L, Falconi M. Enhanced recovery pathways in pancreatic surgery: State of the art. World journal of gastroenterology. 2016;22(28):6456–68. doi:10.3748/wjg.v22.i28.6456.
Lassen K, Coolsen MM, Slim K, Carli F, de Aguilar-Nascimento JE, Schafer M, Parks RW, Fearon KC, Lobo DN, Demartines N, Braga M, Ljungqvist O, Dejong CH. Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS(R)) Society recommendations. World journal of surgery. 2013;37(2):240–58. doi:10.1007/s00268-012-1771
Kim SC, Song KB, Jung YS, Kim YH, Park DH, Lee SS, Seo DW, Lee SK, Kim MH, Park KM, Lee YJ. Short-term clinical outcomes for 100 consecutive cases of laparoscopic pylorus-preserving pancreatoduodenectomy: improvement with surgical experience. Surgical endoscopy. 2013;27(1):95–103. doi:10.1007/s00464-012-2427-9.
Paniccia A, Schulick RD, Edil BH. Total Laparoscopic Pancreaticoduodenectomy: A Single-Institutional Experience. Annals of surgical oncology. 2015;22(13):4380–1. doi:10.1245/s10434-015-4450-2.
Boone BA, Zenati M, Hogg ME, Steve J, Moser AJ, Bartlett DL, Zeh HJ, Zureikat AH. Assessment of quality outcomes for robotic pancreaticoduodenectomy: identification of the learning curve. JAMA surgery. 2015;150(5):416–22. doi:10.1001/jamasurg.2015.17.
Shakir M, Boone BA, Polanco PM, Zenati MS, Hogg ME, Tsung A, Choudry HA, Moser AJ, Bartlett DL, Zeh HJ, Zureikat AH. The learning curve for robotic distal pancreatectomy: an analysis of outcomes of the first 100 consecutive cases at a high-volume pancreatic centre. HPB : the official journal of the International Hepato Pancreato Biliary Association. 2015;17(7):580–6. doi:10.1111/hpb.12412.
Zhang J, Wu WM, You L, Zhao YP. Robotic versus open pancreatectomy: a systematic review and meta-analysis. Annals of surgical oncology. 2013;20(6):1774–80. doi:10.1245/s10434-012-2823-3.
Zureikat AH, Postlewait LM, Liu Y, Gillespie TW, Weber SM, Abbott DE, Ahmad SA, Maithel SK, Hogg ME, Zenati M, Cho CS, Salem A, Xia B, Steve J, Nguyen TK, Keshava HB, Chalikonda S, Walsh RM, Talamonti MS, Stocker SJ, Bentrem DJ, Lumpkin S, Kim HJ, Zeh HJ, III, Kooby DA. A Multi-institutional Comparison of Perioperative Outcomes of Robotic and Open Pancreaticoduodenectomy. Annals of surgery. 2016;264(4):640–9. doi:10.1097/sla.0000000000001869.
Acknowledgements
This was supported in part by training grant NCI 5T32CA106493-09 (D.D.), funds from the Cracchiolo Foundation (D.D.) and the Frederick A. Coller Surgical Society (D.D.)
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Michael H Gerber contributed to the conception of the work; design of the work; acquisition, analysis, and interpretation of data for the work; drafting the work; and revising the work critically for important intellectual content and has agreed to the final version to be published.
Daniel Delitto contributed to the design of the work; acquisition, analysis and interpretation of data for the work; drafting the work; and revising the work critically for important intellectual content and has agreed to the final version to be published.
Cristina J Crippen contributed to the acquisition, analysis, and interpretation of data for the work and revising the work critically for important intellectual content and has agreed to the final version to be published.
Thomas J George Jr. contributed to the acquisition, analysis, and interpretation of data for the work and revising the work critically for important intellectual content and has agreed to the final version to be published.
Kevin E Behrns contributed to the acquisition, analysis, and interpretation of data for the work and revising the work critically for important intellectual content and has agreed to the final version to be published.
Jose G Trevino contributed to the acquisition, analysis, and interpretation of data for the work and revising the work critically for important intellectual content and has agreed to the final version to be published.
Jessica L Cioffi contributed to the acquisition, analysis, and interpretation of data for the work and revising the work critically for important intellectual content and has agreed to the final version to be published.
Steven J Hughes contributed to the conception of the work design; acquisition, analysis, and interpretation of data for the work; drafting the work; and revising the work critically for important intellectual content and has agreed to the final version to be published.
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Gerber, M.H., Delitto, D., Crippen, C.J. et al. Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy. J Gastrointest Surg 21, 1404–1410 (2017). https://doi.org/10.1007/s11605-017-3466-2
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DOI: https://doi.org/10.1007/s11605-017-3466-2