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Readmission Following Gastric Cancer Resection: Risk Factors and Survival

  • 2015 SSAT Quick Shot Presentation
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

This study utilized a multi-institutional database to evaluate risk factors for readmission in patients undergoing curative gastrectomy for gastric adenocarcinoma with the intent of describing both perioperative risk factors and the relationship of readmission to survival.

Methods

Patients who underwent curative resection of gastric adenocarcinoma from 2000 to 2012 from seven academic institutions of the US Gastric Cancer Collaborative were analyzed. In-hospital deaths and palliative surgeries were excluded, and readmission was defined as within 30 days of discharge. Univariate and multivariable logistic regression analyses were employed and survival analysis conducted.

Results

Of the 855 patients, 121 patients (14.2 %) were readmitted. Univariate analysis identified advanced age (p < 0.0128), American Society of Anesthesiology status ≥3 (p = 0.0045), preexisting cardiac disease (p < 0.0001), hypertension (p = 0.0142), history of smoking (p = 0.0254), increased preoperative blood urea nitrogen (BUN; p = 0.0426), concomitant pancreatectomy (p = 0.0056), increased operation time (p = 0.0384), estimated blood loss (p = 0.0196), 25th percentile length of stay (<7 days, p = 0.0166), 75th percentile length of stay (>12 days, p = 0.0256), postoperative complication (p < 0.0001), and total gastrectomy (p = 0.0167) as risk factors for readmission. Multivariable analysis identified cardiac disease (odds ratio (OR) 2.4, 95 % confidence interval (CI) 1.6–3.3, p < 0.0001), postoperative complication (OR 2.3, 95 % CI 1.6–5.4, p < 0.0001), and pancreatectomy (OR 2.2, 95 % CI 1.1–4.1, p = 0.0202) as independent risk factors for readmission. There was an association of decreased overall median survival in readmitted patients (39 months for readmitted vs. 103 months for non-readmitted). This was due to decreased survival in readmitted stage 1 (p = 0.0039), while there was no difference in survival for other stages. Stage I readmitted patients had a higher incidence of cardiac disease than stage I non-readmitted patients (58 vs. 24 %, respectively, p = 0.0002).

Conclusions

Within this multi-institutional study investigating readmission in patients undergoing curative resection for gastric cancer, cardiac disease, postoperative complication, and concomitant pancreatectomy were identified as significant risk factors for readmission. Readmission was associated with decreased overall median survival, but on further analysis, this was driven by differences in survival for stage I disease only.

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Authors and Affiliations

  1. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Alexandra W. Acher, Emily Winslow, Clifford S. Cho, Glen Leverson & Sharon M. Weber

  2. Emory University, Atlanta, GA, USA

    Malcolm H. Squires, David A. Kooby & Shishir K. Maithel

  3. Washington University School of Medicine, St. Louis, MO, USA

    Ryan C. Fields & Linda X. Jin

  4. Stanford University, Stanford, CA, USA

    George A. Poultsides & David Worhunsky

  5. Wake Forest University, Winston-Salem, NC, USA

    Konstantinos I. Votanopoulos & Edward A. Levine

  6. The Johns Hopkins University, Baltimore, MD, USA

    Timothy M. Pawlik & Aslam Ejaz

  7. Ohio State University, Columbus, OH, USA

    Carl Schmidt, Mark Bloomston & Neil Saunders

  8. Department of General Surgery, H4/730, 7375 Clinical Science Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA

    Sharon M. Weber

Authors
  1. Alexandra W. Acher
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  2. Malcolm H. Squires
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  3. Ryan C. Fields
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  4. George A. Poultsides
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  5. Carl Schmidt
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  6. Konstantinos I. Votanopoulos
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  7. Timothy M. Pawlik
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  8. Linda X. Jin
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  9. Aslam Ejaz
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  10. David A. Kooby
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  11. Mark Bloomston
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  12. David Worhunsky
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  13. Edward A. Levine
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  14. Neil Saunders
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  15. Emily Winslow
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  16. Clifford S. Cho
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  17. Glen Leverson
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  18. Shishir K. Maithel
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  19. Sharon M. Weber
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Corresponding author

Correspondence to Sharon M. Weber.

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Acher, A.W., Squires, M.H., Fields, R.C. et al. Readmission Following Gastric Cancer Resection: Risk Factors and Survival. J Gastrointest Surg 20, 1284–1294 (2016). https://doi.org/10.1007/s11605-015-3070-2

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  • DOI: https://doi.org/10.1007/s11605-015-3070-2

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