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Risk of anastomotic leakage with nonsteroidal anti-inflammatory drugs within an enhanced recovery program

  • Original Research
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Anastomotic leakage is a serious complication after colorectal resection. Recent studies suggest that nonsteroidal anti-inflammatory drugs may increase the risk of anastomotic leakage. We investigated this association in our enhanced recovery population.

Material and Methods

Patients undergoing an elective colon or rectal resection with primary anastomosis because of malignancy and treated within our enhanced recovery program were included. Univariable and multivariable logistic regression analyses were used to study risk factors for anastomotic leakage.

Results

Between 2006 and 2013, 856 patients were included. The anastomotic leakage rate was significantly higher in the group that received nonsteroidal anti-inflammatory drugs compared to patients who did not: 9.2 vs. 5.3 %, p = 0.038. This higher rate was only seen in patients receiving diclofenac: for colonic resections, 11.8 vs. 6.0 %, p = 0.016; for rectal resections, 13.1 vs. 0 %, p = 0.017. Only male sex (odds ratio 2.20, p = 0.005) was also independently associated with anastomotic leakage.

Conclusion

The results of this study are in line with other comparable studies in the literature, showing an increased risk for anastomotic leakage with diclofenac. The use of diclofenac in colorectal surgery can no longer be recommended. Alternatives for postoperative analgesia need to be explored within an enhanced recovery program.

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Authors and Affiliations

  1. Medical Center Alkmaar, Alkmaar, The Netherlands

    Nathalie Bakker, Jort. D. Deelder, Milan.C. Richir, Hamit Cakir, Hiëronymus J. Doodeman, Wilhelmina. H. Schreurs & Alexander P.J. Houdijk

  2. VU Medical Center, Amsterdam, The Netherlands

    Nathalie Bakker, Jort. D. Deelder, Milan.C. Richir & Alexander P.J. Houdijk

Authors
  1. Nathalie Bakker
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  2. Jort. D. Deelder
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  3. Milan.C. Richir
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  4. Hamit Cakir
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  5. Hiëronymus J. Doodeman
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  6. Wilhelmina. H. Schreurs
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  7. Alexander P.J. Houdijk
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Correspondence to Nathalie Bakker.

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Bakker, N., Deelder, J.D., Richir, M. et al. Risk of anastomotic leakage with nonsteroidal anti-inflammatory drugs within an enhanced recovery program. J Gastrointest Surg 20, 776–782 (2016). https://doi.org/10.1007/s11605-015-3010-1

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  • DOI: https://doi.org/10.1007/s11605-015-3010-1

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