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Effect of Intramuscular Adipose Tissue Content on Prognosis in Patients Undergoing Hepatocellular Carcinoma Resection

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

It has recently been reported that myosteatosis, the infiltration of fat in skeletal muscle, is associated with insulin resistance and type 2 diabetes mellitus. The present study investigated the effect of skeletal muscle fat accumulation on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC) and aimed to identify prognostic factors.

Methods

The records of 141 HCC patients who underwent hepatectomy were retrospectively reviewed. Clinicopathological and outcome data from 71 patients with high intramuscular adipose tissue content (IMAC) were compared with those from 70 patients with low IMAC.

Results

The 5-year overall survival rate was 46 % among patients with high IMAC and 75 % among those with low IMAC. The 5-year disease-free survival rates in these groups were 18 and 38 %, respectively. Multivariate analysis revealed that high IMAC was predictive of an unfavorable prognosis. High IMAC was significantly correlated with liver dysfunction, higher intraoperative blood loss, the need for blood transfusion, and comorbid diabetes mellitus.

Conclusions

Greater fat accumulation in skeletal muscle was predictive of worse overall survival after partial hepatectomy in patients with HCC, even with adjustment for other known predictors. The identification of patients with greater skeletal muscle fat accumulation before hepatectomy could permit early preventive strategies to maintain muscle quality and thus improve prognosis and patient selection for hepatectomy.

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Conflict of Interest

We do not have any financial support or relationships that may pose a conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1191, Japan

    Masaki Kaibori, Morihiko Ishizaki, Hiroya Iida, Kosuke Matsui, Tatsuma Sakaguchi, Kentaro Inoue & Masanori Kon

  2. Department of Internal Medicine, Saga Medical School, Saga University, Saga, 849-8501, Japan

    Toshihiko Mizuta & Yasushi Ide

  3. Second Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, 573-1191, Japan

    Junji Iwasaka

  4. Health Science Center, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, 573-1191, Japan

    Yutaka Kimura

  5. Department of Nutritional Medicine, Graduate School of Human Life Science, Osaka City University, Osaka, 545-8585, Japan

    Fumikazu Hayashi & Daiki Habu

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  1. Masaki Kaibori
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  2. Morihiko Ishizaki
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  3. Hiroya Iida
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  13. Masanori Kon
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Correspondence to Masaki Kaibori.

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Kaibori, M., Ishizaki, M., Iida, H. et al. Effect of Intramuscular Adipose Tissue Content on Prognosis in Patients Undergoing Hepatocellular Carcinoma Resection. J Gastrointest Surg 19, 1315–1323 (2015). https://doi.org/10.1007/s11605-015-2838-8

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  • DOI: https://doi.org/10.1007/s11605-015-2838-8

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