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Strong YB-1 Expression Predicts Liver Recurrence Following Resection for Colorectal Metastases

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Introduction

The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection.

Materials and Methods

Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity).

Results

YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and strong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5 % (p = 0.023). Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 % in the strong expression group (p = 0.034). These results were not influenced by clinical prognostic factors of tumor recurrence.

Conclusions

This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection.

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Conflict of Interest

No grants or other financial supports have been received from industry or private corporations. The authors have nothing to disclose.

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Authors and Affiliations

  1. Hepatobiliary Surgery Unit, Department of Surgery, School of Medicine, Catholic University of the Sacred Heart, L.go A. Gemelli, 8, I-00168, Rome, Italy

    Francesco Ardito, Maria Vellone, Gennaro Grande, Ivo Giovannini, Gennaro Nuzzo & Felice Giuliante

  2. Department of Pathology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy

    Vincenzo Arena, Ilaria Pennacchia, Francesco Majellaro & Fabio M. Vecchio

Authors
  1. Francesco Ardito
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  2. Vincenzo Arena
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  3. Maria Vellone
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  4. Gennaro Grande
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  6. Francesco Majellaro
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  7. Ivo Giovannini
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  9. Gennaro Nuzzo
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  10. Felice Giuliante
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Correspondence to Francesco Ardito.

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Ardito, F., Arena, V., Vellone, M. et al. Strong YB-1 Expression Predicts Liver Recurrence Following Resection for Colorectal Metastases. J Gastrointest Surg 18, 1987–1993 (2014). https://doi.org/10.1007/s11605-014-2657-3

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  • DOI: https://doi.org/10.1007/s11605-014-2657-3

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