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The Study on the Efficacy of Fibrin Glue in Preventing Post-traumatic Focal Pancreatitis (PTFP) After Radical Gastrectomy

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Objective

This study was intended to evaluate the efficacy of fibrin glue (FG) in preventing post-traumatic focal pancreatitis (PTFP) after radical gastrectomy by examining the drainage fluids over 7 days post-op.

Methods

Ninety-five patients who underwent D2 radical gastrectomy for gastric cancer were randomly assigned to a fibrin glue group (n = 48) receiving fibrin glue on the raw surface of the pancreas during surgery and a control group (n = 47), which did not receive fibrin glue.

Results

We found no significant difference in operation time and intraoperative blood loss between groups (p > 0.05); no deaths occurred during surgery. The volume of ascitic fluid containing blood cells in the fibrin glue group was significantly lower than that in the control group (p < 0.001) at all times observed. Amylase levels in the drained fluids were highest at 24 h postoperatively in both groups, suggesting pancreatitis, but gradually decreased to normal levels within 7 days. The amylase in the drains in the control group was significantly higher than that in the FG group (p < 0.001) at all times observed, but it returned to normal 72 h postoperatively in the FG group. One death by hemorrhagic shock associated with PTFP was recorded in the control group.

Conclusion

Fibrin glue is safe and effective in preventing PTFP following gastric surgery and shortens the clinical course of the disease.

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References

  1. Testi W, Staffieri C, Malatesti R, Macchitella Y, De Martino A, Botta G, et al. Postoperative acute pancreatitis: our experience and review of the literature. Minerva chirurgica. 2007;62:19-24.

    CAS  PubMed  Google Scholar 

  2. Suzuki Y, Kuroda Y, Morita A, Fujino Y, Tanioka Y, Kawamura T, et al. Fibrin glue sealing for the prevention of pancreatic fistulas following distal pancreatectomy. Archives of Surgery. 1995;130:952-5.

    Article  CAS  PubMed  Google Scholar 

  3. Boris WJ, Gu J, McGrath LB. Effectiveness of fibrin glue in the reduction of postoperative intrapericardial adhesions. Journal of investigative surgery. 1996;9:327-33

    Article  CAS  PubMed  Google Scholar 

  4. Tashiro S, Murata E, Hiraoka T, Nakakuma K, Watanabe E, Miyauchi Y. New technique for pancreaticojejunostomy using a biological adhesive. The British journal of surgery. 1987;74:392-4.

    Article  CAS  PubMed  Google Scholar 

  5. Toosie K, Gallego K, Stabile BE, Schaber B, French S, de Virgilio C. Fibrin glue reduces intra-abdominal adhesions to synthetic mesh in a rat ventral hernia model. The American surgeon. 2000;66:41-5.

    CAS  PubMed  Google Scholar 

  6. Dulchavsky SA, Geller ER, Maurer J, Kennedy PR, Tortora GT, Maitra SR. Autologous fibrin gel: bactericidal properties in contaminated hepatic injury. The Journal of trauma. 1991;31:991-4.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Jiangyin People’s Hospital, Jiangyin, Jiangsu Province, China, 214400

    Jianming Huang & Leimin Qian

Authors
  1. Jianming Huang
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  2. Leimin Qian
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Correspondence to Jianming Huang.

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Huang, J., Qian, L. The Study on the Efficacy of Fibrin Glue in Preventing Post-traumatic Focal Pancreatitis (PTFP) After Radical Gastrectomy. J Gastrointest Surg 18, 476–480 (2014). https://doi.org/10.1007/s11605-013-2442-8

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  • DOI: https://doi.org/10.1007/s11605-013-2442-8

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