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Clinical Significance of Incidental Colonic 18F-FDG Uptake on PET/CT Images in Patients with Gastric Adenocarcinoma

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background and Objectives

We assessed the ability of positron emission tomography–computed tomography (PET/CT) to detect synchronous colonic pathology and determined the significance of 18F-fluorodeoxyglucose (18F-FDG) activity in the colon of gastric cancer patients.

Methods

A total of 239 gastric cancer patients who underwent PET/CT and colonoscopy preoperatively were included. FDG uptake patterns on PET/CT were classified as (1) group A, focal; (2) group B, diffuse; and (3) group C, no uptake. The PET/CT findings were compared with the results of concurrent colonoscopy.

Results

In group A, a total of 123 polyps of >0 mm were observed. Of these, nine polyps were colonic adenocarcinomas and six were high-grade dysplasia. The incidence of colonic adenocarcinomas was significantly higher in group A than in the other two groups (p = 0.037). There was a significant correlation between SUVmax values and incidence of colonic polyps of >10 mm (r = 0.471, p = 0.04). The distribution pattern of SUVmax in polyps with adenoma (>10 mm) was less homogenous than in polyps (>10 mm) with adenocarcinoma.

Conclusions

The focal colonic FDG uptake in PET/CT requires colonoscopic confirmation. The suspicion of colonic malignancy increased in the presence of polyps >10 mm that showed a positive correlation with the SUVmax.

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Authors and Affiliations

  1. Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, South Korea

    Jung Ho Shim, Seong Il Oh, Han Mo Yoo, Hae Myung Jeon, Cho Hyun Park & Kyo Young Song

  2. Department of Radiology, The Catholic University of Korea, Seoul, South Korea

    Joo Hyun O & Sung Hoon Kim

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  1. Jung Ho Shim
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  2. Joo Hyun O
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  3. Seong Il Oh
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  4. Han Mo Yoo
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  5. Hae Myung Jeon
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  6. Cho Hyun Park
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  7. Sung Hoon Kim
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  8. Kyo Young Song
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Correspondence to Kyo Young Song.

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Shim, J.H., O, J.H., Oh, S.I. et al. Clinical Significance of Incidental Colonic 18F-FDG Uptake on PET/CT Images in Patients with Gastric Adenocarcinoma. J Gastrointest Surg 16, 1847–1853 (2012). https://doi.org/10.1007/s11605-012-1941-3

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  • DOI: https://doi.org/10.1007/s11605-012-1941-3

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