Skip to main content
Log in

Outcome of Right Hepatectomy for Living Liver Donors: A Single Egyptian Center Experience

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

This study aims to evaluate living liver donor outcome after right hepatectomy in a single Egyptian center.

Patients and Methods

Between April 2004 and July 2010, 100 living donors underwent right hepatectomy. Their medical records and postoperative follow-up visits were retrospectively revised. Perioperative complications were reported. Postoperative complications were classified according to the five tier version of Clavien system.

Results

There were 71 males and 29 females. The mean age was 27.6 ± 7.4 years. The mean graft weight was 999 ± 167 g and the mean volume percent of the remaining liver was 36.8 ± 8%. The mean ICU and hospital stay were 2.6 ± 2.7 and 12.4 ± 9.1, respectively. A total of 57 complications developed in 38 donors (38%). The commonest complication type was biliary complications. There were 22 grade I, 6 grade II, 15 grade IIIa, 12 grade IIIb, 1 grade IVa, and 1 grade V complications. One donor died due to posttransfusion ARDS on the 30th postoperative day. On follow-up, no donor developed long lasting disability. A donor died in a road traffic accident 1 year after donation.

Discussion and Conclusions

Donor right hepatectomy is not an entirely safe procedure. Biliary complications are the commonest early postoperative complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Sevmis S, Karakayali H, Karakayali F, Savas NA, Akkoc H, Haberal M. Postsurgical complications in living-related liver donors. Transplant Proc. 2008; 40: 245-7.

    Article  PubMed  CAS  Google Scholar 

  2. Yi NJ, Suh KS, Cho JY, et al. Three-quarters of right liver donors experienced postoperative complications. Liver Transpl. 2007; 13: 797-806.

    Article  PubMed  Google Scholar 

  3. Wiederkehr JC, Pereira JC, Ekermann M, et al. Results of 132 hepatectomies for living donor liver transplantation: report of one death. Transplant Proc. 2005; 37: 1079-80.

    Article  PubMed  CAS  Google Scholar 

  4. Brown RS, Jr., Russo MW, Lai M, et al. A survey of liver transplantation from living adult donors in the United States. N Engl J Med. 2003; 348: 818-25.

    Article  PubMed  Google Scholar 

  5. Middleton PF, Duffield M, Lynch SV, et al. Living donor liver transplantation—adult donor outcomes: a systematic review. Liver Transpl. 2006; 12: 24-30.

    Article  PubMed  Google Scholar 

  6. Akabayashi A, Slingsby BT, Fujita M. The first donor death after living-related liver transplantation in Japan. Transplantation. 2004; 77: 634.

    Article  PubMed  Google Scholar 

  7. Beavers KL, Sandler RS, Shrestha R. Donor morbidity associated with right lobectomy for living donor liver transplantation to adult recipients: a systematic review. Liver Transpl. 2002; 8: 110-7.

    Article  PubMed  Google Scholar 

  8. Belghiti J, Guevara OA, Noun R, Saldinger PF, Kianmanesh R. Liver hanging maneuver: a safe approach to right hepatectomy without liver mobilization. J Am Coll Surg. 2001; 193: 109-11.

    Article  PubMed  CAS  Google Scholar 

  9. Dindo D, Demartines N, Clavien P. Classification of surgical complications: a new proposal with evaluation in a cohort of a 6336 patients and results of a survey. Ann Surg. 2004; 240.

  10. Raia S, Nery JR, Mies S. Liver transplantation from live donors. Lancet. 1989; 2: 497.

    Article  PubMed  CAS  Google Scholar 

  11. Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA. Successful liver transplantation from a living donor to her son. N Engl J Med. 1990; 322: 1505-7.

    Article  PubMed  CAS  Google Scholar 

  12. Broelsch CE, Emond JC, Whitington PF, Thistlethwaite JR, Baker AL, Lichtor JL. Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants. Ann Surg. 1990; 212: 368-75; discussion 75-7.

    Google Scholar 

  13. Hashikura Y, Makuuchi M, Kawasaki S, et al. Successful living-related partial liver transplantation to an adult patient. Lancet. 1994; 343: 1233-4.

    Article  PubMed  CAS  Google Scholar 

  14. Yamaoka Y, Washida M, Honda K, et al. Liver transplantation using a right lobe graft from a living related donor. Transplantation. 1994; 57: 1127-30.

    PubMed  CAS  Google Scholar 

  15. Lo CM, Fan ST, Liu CL, et al. Adult-to-adult living donor liver transplantation using extended right lobe grafts. Ann Surg. 1997; 226: 261-9; discussion 9-70.

    Article  PubMed  CAS  Google Scholar 

  16. Khalaf H, Al-Sofayan M, El-Sheikh Y, Al-Bahili H, Al-Sagheir M, Al-Sebayel M. Donor Outcome After Living Liver Donation: A Single-Center Experience. Transplantation Proc. 2007; 39: 829–34.

    Article  CAS  Google Scholar 

  17. Salvalaggio PR, Baker TB, Koffron AJ, et al. Comparative analysis of live liver donation risk using a comprehensive grading system for severity. Transplantation. 2004; 77: 1765-7.

    Article  PubMed  Google Scholar 

  18. Renz JF, Kin CJ, Saggi BH, Emond JC. Outcomes of living donor liver transplantation. In: Busuttil RW, Klintmalm G, eds. Transplantation of the liver. Elsevier, Philadelphia, 2005: 713-24.

    Chapter  Google Scholar 

  19. Lo CM. Complications and long-term outcome of living liver donors: a survey of 1,508 cases in five Asian centers. Transplantation. 2003; 75: S12-5.

    Article  PubMed  Google Scholar 

  20. Hwang S, Lee SG, Lee YJ, et al. Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl. 2006; 12: 920-7.

    Article  PubMed  Google Scholar 

  21. Chan SC, Fan ST, Lo CM, Liu CL. Effect of side and size of graft on surgical outcomes of adult-to-adult live donor liver transplantation. Liver Transpl. 2007; 13: 91-8.

    Article  PubMed  Google Scholar 

  22. Chan SC, Fan ST, Lo CM, Liu CL, Wong J. Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases. Ann Surg. 2007; 245: 110-7.

    Article  PubMed  Google Scholar 

  23. Marsh JW, Gray E, Ness R, Starzl TE. Complications of right lobe living donor liver transplantation. J Hepatol. 2009; 51: 715-24.

    Article  PubMed  Google Scholar 

  24. Clavien PA, Camargo CA, Jr., Croxford R, Langer B, Levy GA, Greig PD. Definition and classification of negative outcomes in solid organ transplantation. Application in liver transplantation. Ann Surg. 1994; 220: 109-20.

    Article  PubMed  CAS  Google Scholar 

  25. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240: 205-13.

    Article  PubMed  Google Scholar 

  26. Barr ML, Belghiti J, Villamil FG, et al. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation. 2006; 81: 1373-85.

    Article  PubMed  Google Scholar 

  27. Gruttadauria S, Marsh JW, Vizzini GB, et al. Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation. World J Gastroenterol. 2008; 14: 3159-64.

    Article  PubMed  Google Scholar 

  28. Ito T, Kiuchi T, Egawa H, et al. Surgery-related morbidity in living donors of right-lobe liver graft: lessons from the first 200 cases. Transplantation. 2003; 76: 158-63.

    Article  PubMed  Google Scholar 

  29. Shah SA, Grant DR, Greig PD, et al. Analysis and outcomes of right lobe hepatectomy in 101 consecutive living donors. Am J Transplant. 2005; 5: 2764-9.

    Article  PubMed  Google Scholar 

  30. Ghobrial RM, Freise CE, Trotter JF, et al. Donor morbidity after living donation for liver transplantation. Gastroenterology. 2008; 135: 468-76.

    Article  PubMed  Google Scholar 

  31. Chan SC, Fan ST. Historical perspective of living donor liver transplantation. World J Gastroenterol. 2008; 14: 15-21.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to acknowledge the effort of our late professor Farouk Ezzat who founded the liver transplantation unit in our center. Also, we would like to acknowledge the help of Professor Olivier Boillot during the first 34 LDLT cases.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ahmad M. Sultan.

Additional information

This work is to be attributed to Gastroenterology Surgical Center, Mansoura Faculty of Medicine, Mansura University.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salah, T., Sultan, A.M., Fathy, O.M. et al. Outcome of Right Hepatectomy for Living Liver Donors: A Single Egyptian Center Experience. J Gastrointest Surg 16, 1181–1188 (2012). https://doi.org/10.1007/s11605-012-1851-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-012-1851-4

Keywords

Navigation